Top 50 Biofoundry

Uses genomic optimization and digital tools to engineer diverse genomes from underexplored organisms like filamentous fungi, enabling the sustainable and cost-competitive biomanufacturing of a wider range of valuable products. This approach addresses the limitations of traditional biomanufacturing by expanding the raw material portfolio and improving efficiency in producing biologically derived substances.

EV Biotech develops microbial cell factories that utilize synthetic biology techniques for the industrial production of chemicals and proteins. This approach addresses the need for sustainable and efficient manufacturing processes in the chemical and biotechnology sectors.

This synthetic biology company utilizes a cell-free protein production platform combined with artificial intelligence to streamline the manufacturing of custom proteins. By simplifying the ordering process through an e-commerce model, it enables biotechnology firms to quickly access tailored protein solutions, enhancing their research and development capabilities.

The startup develops machine-learning tools to design cell factories capable of producing a wide range of products, including food, fabrics, and medicines. By simplifying the complex process of cellular manufacturing, the company aims to replace traditional farms and factories, promoting a more sustainable production model.

The startup utilizes a biosynthetic mapping approach combined with experimental data analysis to identify microbial genes that can produce novel drug compounds. This enables pharmaceutical companies and research institutions to access unique molecules with potential new mechanisms for drug development.

The startup develops a synthetic biology plant architecture that utilizes proprietary hyper-integration algorithms and precision fermentation to create customized modular plant systems at scale. This approach significantly reduces the time and costs associated with bringing synthetic biology products to market, addressing inefficiencies in traditional biomanufacturing processes.

Aether Bio develops machine learning algorithms and proprietary robotic hardware to engineer enzymes for the production of complex biochemical compounds. This technology enables manufacturers to create novel products at significantly reduced costs by efficiently indexing and searching trillions of enzyme sequences.

Enzymit develops a cell-free bioproduction platform utilizing computational protein design and high-throughput testing to create novel enzymes for various industries, including biochemicals and health. This technology addresses the inefficiencies and high costs associated with traditional enzymatic manufacturing processes, enabling faster and more sustainable production.

Bota Bio utilizes synthetic biology and enzyme engineering to produce high-quality bio-preservatives and nutritional supplements from renewable resources, significantly reducing raw material and energy consumption. Their technology addresses the demand for sustainable solutions in the food and personal care industries by replacing petroleum-based processes with efficient biomanufacturing methods.

Constructive.Bio utilizes a dual-technology platform that combines de novo genome synthesis and engineered translation to create programmable biomolecules with high fidelity. This approach addresses the limitations of traditional biomanufacturing by enabling the production of customized bioproducts, including phage-resistant strains and next-generation therapeutics.

Synonym develops biomanufacturing infrastructure and a dynamic database of contract manufacturers to facilitate the commercialization of next-generation bioproducts. By providing techno-economic analysis and lifecycle assessments, the company helps businesses scale production efficiently while addressing the challenges of supply chain sustainability and decarbonization.

Arsenale BioYards is a bio-manufacturing platform that combines hardware and software to facilitate the design and cultivation of engineered cells for product creation. This technology enables a shift from resource extraction to sustainable cellular farming, addressing the need for a more efficient and environmentally friendly bioeconomy.

21st Bio develops sustainable bio-based alternatives to replace traditional meals and materials, utilizing advanced fermentation processes and strain optimization for high product yield and stability. The company addresses the need for environmentally friendly solutions in food and material production, enabling businesses to reduce their ecological footprint while maintaining quality.

Develops scalable biocatalysis solutions that produce essential chemicals from sustainable carbon sources using engineered enzymes and whole-cell catalysts. This process reduces reliance on fossil fuels and enables environmentally friendly manufacturing by optimizing catalyst performance and integrating with existing production systems.

The startup develops a proprietary microbial platform using synthetic biology to create sustainable products, including chemicals and food ingredients, from diverse microbial strains sourced from wild biomes. This approach reduces reliance on petroleum and animal products while lowering production costs and increasing the scalability of biomanufactured goods.

Bactobio utilizes synthetic biology, next-generation sequencing, and machine learning to culture previously unculturable microbes, unlocking new chemical and biological products. The company focuses on discovering novel antibiotics for severe bacterial infections and developing sustainable plant protection solutions.

Pearl Bio utilizes genome and ribosome engineering to create novel biomaterials with customizable properties for smart biologics. This technology addresses the limitations of traditional biologics by enabling the production of materials with diverse chemistries that were previously unattainable.

Liberation Labs utilizes precision fermentation technology to produce alternative proteins and bioproducts at commercial scale, addressing the capacity bottlenecks in biomanufacturing. Their facility in Indiana aims to meet the growing demand for sustainable and environmentally friendly food and materials, enabling manufacturers to efficiently scale their production.

FabricNano develops cell-free biomanufacturing processes that utilize biocatalysts and natural materials to produce sustainable products. This technology addresses the environmental impact of traditional manufacturing by enabling efficient, eco-friendly production methods.

Pow.bio has developed a high-efficiency fermentation platform that decouples biomass growth from product production, addressing issues of contamination and genetic drift in biomanufacturing. This technology enables manufacturers to achieve 2-5 times more product output while reducing production costs by 40-70%.

Immobazyme produces recombinant growth factors for cellular agriculture using a modular protein expression system, enabling scalable and cost-effective solutions that eliminate the need for animal-derived products. The company also offers contract research services focused on waste valorization and downstream processing optimization, enhancing product efficiency and sustainability for various industries.

Primrose Bio develops and manufactures novel molecules for use in biotechnology applications. The company focuses on creating new molecular entities for research and potential therapeutic applications.

Tailwind Biotech provides artificial DNA design services using proprietary artificial intelligence to optimize DNA sequences for bioproduction companies. This technology enhances gene expression and reduces development costs, enabling more efficient and effective genetic engineering processes.

This biotechnology company utilizes artificial intelligence to cultivate and evolve proteins essential for bio-products, enhancing the efficiency of medical research. By providing reliable and rapid access to these proteins, the company addresses the need for improved medical services in the healthcare sector.

Allozymes utilizes proprietary microfluidics technology to rapidly engineer and optimize custom enzymes, significantly increasing the speed of development and success rates in enzyme production. This approach addresses the environmental impact of traditional manufacturing methods by providing cleaner, more efficient biocatalytic processes for producing natural ingredients.

Scorpius Biomanufacturing is a U.S.-based CDMO that provides cGMP manufacturing and bioanalytical services for mammalian and microbial biologics, focusing on small-volume programs for emerging biotechs and academic researchers. The company addresses the need for reliable and efficient biomanufacturing capacity in the U.S. by offering integrated process development and analytical expertise to accelerate the path to market for biologics.

Think Bioscience utilizes living systems to program cells for the design and assembly of small-molecule therapeutics targeting difficult-to-address medical conditions. Their platform integrates applied microbiology, enzymology, and data science to enhance the efficiency of drug development processes.

This startup develops DNA technology tailored for synthetic biology applications, providing high-throughput libraries and custom DNA sequences for genome construction and data storage. Their services enable researchers and companies to efficiently create and manipulate DNA without facing economic or time constraints.

The startup provides bioprocessing solutions that enhance the development and manufacturing of biologic therapies through advanced cell culture and purification techniques. By streamlining these processes, the company enables biopharmaceutical and contract manufacturing organizations to accelerate the delivery of safe therapies to patients.

The startup operates a synthetic biology platform that designs and manufactures biomedicines by creating product-specific libraries of synthetic genetic parts. By utilizing bioinformatic analysis of genome-scale data, the company enables clients to engineer novel biomolecules tailored to specific therapeutic properties.

CysBio utilizes metabolic engineering and synthetic biology to develop bacterial cell factories that convert renewable feedstocks into commodity chemicals and novel materials. Their technology addresses the need for sustainable production of amino acids, functional polymer precursors, and biodegradable antifouling agents, enhancing the efficiency and environmental impact of chemical manufacturing.

Cell Bauhaus develops a virtual cell technology platform that enables the computer-aided design and simulation of living systems, allowing researchers to optimize genetic constructs and cellular behavior before laboratory experimentation. This approach significantly reduces the time and cost associated with bringing synthetic biology products to market by minimizing trial and error in the development process.

bitBiome utilizes single-cell sequencing technology to catalog and evolve microbial genomes, creating a diverse database of over 2 billion sequences. This platform addresses the need for unique enzymes and proteins to enhance biomanufacturing processes across various industries, including drug production and sustainable materials development.

This startup develops industrial biocatalysts that enhance the stability and activity of natural enzymes for biomanufacturing processes. Their catalysts overcome the limitations of traditional enzymes, enabling more efficient and durable production cycles.

ScaleUp Bio provides end-to-end contract development and manufacturing organization (CDMO) services in precision fermentation, facilitating the scale-up of microbial processes from laboratory to pilot production for food tech startups. By optimizing fermentation and downstream processing, the company addresses the challenge of bringing innovative food products to market efficiently while maintaining strict food safety standards.

KBio utilizes a plant-based platform to manufacture high-quality proteins and bioactive compounds at scale, addressing the need for rapid development of therapeutics in health and medicine. This efficient process leverages strategic global partnerships to enhance the production capabilities of biologics, overcoming traditional manufacturing limitations.

The startup operates a precision fermentation facility in Espoo, Finland, providing scale-up piloting services for the fermentation of materials, chemicals, food, and feed. This enables companies to efficiently transition their biotech innovations from laboratory-scale to commercial production, addressing the challenges of scalability in the biotechnology sector.

The startup has developed a recombinant protein production technology that removes the origin of replication from bacterial chromosomes, allowing cells to remain metabolically active without dividing. This approach enables users to decouple protein production from cellular growth, enhancing yield and efficiency in biomanufacturing processes.

Provides an open-source synthetic cell platform, Nucleus, that enables the engineering of biological systems for research and application development. This platform addresses the challenges of building and manipulating cellular models by offering standardized tools and frameworks for creating synthetic cells, facilitating advancements in biotechnology and synthetic biology.

Alagene offers integrated biotechnology solutions that accelerate bioproduct development from computational design and cell engineering to precision fermentation and downstream processing. They leverage high-throughput screening and advanced genetic tools to optimize biological systems, enabling efficient scale-up and commercialization for biotech and pharmaceutical companies.

This startup operates a biomanufacturing plant that specializes in precision fermentation, utilizing fermenters with real-time monitoring and control of pH, temperature, gas flow, and agitation. By providing bench-scale derisking, the company enables food and agriculture biotechnology firms to efficiently scale their sustainable innovations.

Enzyan Biocatalysis develops in vitro biocatalytic cascades that utilize compatible enzymes to convert renewable feedstocks into value-added chemical products, eliminating the need for living cells. This approach addresses inefficiencies in traditional chemical synthesis by streamlining reactions into a single vessel, reducing costs and environmental impact in chemical manufacturing.

Biomatter utilizes its Intelligent Architecture™ platform to engineer proteins and enzymes with precise control for applications in health and sustainable manufacturing. The company provides environmentally friendly alternatives to traditional materials and enhances therapeutic efficacy through advanced protein design.

Terra Bioforge develops proprietary technology to activate cryptic biosynthetic gene clusters, enabling the efficient production of microbial natural products. This approach expands access to nature's chemistry, addressing the challenge of underutilized natural resources in drug discovery and development.

Abiochem Biotechnology specializes in synthetic biology, focusing on enzyme and genetic engineering to create high-performance microbial cell factories for large-scale production. The company addresses the need for sustainable and efficient manufacturing processes in pharmaceuticals, agriculture, and food industries by leveraging its extensive enzyme library and advanced design platforms.

Cultiply specializes in industrial microbiology and fermentation technologies to develop biological products, offering tailored bioprocess development and production services from laboratory scale to industrial manufacturing. The company addresses the need for efficient and sustainable production of high-value bioproducts, such as proteins and biofertilizers, by optimizing fermentation processes and designing custom bioreactors.

The startup utilizes an AI algorithm to design and optimize biocatalysts for the chemical synthesis industry, enhancing resource efficiency and reducing waste. This technology addresses the high costs and environmental impact associated with traditional chemical processes.

This startup engineers microbial strains to produce sustainable chemicals and materials. They leverage synthetic biology and genome editing to optimize microorganisms for industrial biomanufacturing processes.

This startup engineers biotechnological solutions that optimize industrial processes through the application of synthetic biology and bioprocessing techniques. By enhancing resource efficiency, they aim to reduce waste and lower the environmental impact of industrial operations.

Cataya Bio engineers microbial strains to produce high-value chemicals and biochemicals through fermentation. Their synthetic biology platform optimizes metabolic pathways for efficient and sustainable biomanufacturing.