Officinae Bio provides a biological design and manufacturing platform that specializes in synthesizing complex DNA constructs and RNA transcripts, enabling the creation of sophisticated genetic variant libraries. This technology supports researchers in developing programmable therapies and precise genetic solutions to advance their scientific inquiries.
Funding
Funding not disclosed
Founders
Product
Problem
Developing advanced therapies and conducting complex biological research often requires the synthesis of sophisticated DNA constructs and RNA transcripts, which can be challenging and time-consuming using traditional methods. Researchers may face limitations in sequence complexity, length, and the ability to create diverse variant libraries, hindering their progress in developing programmable therapies and precise genetic solutions.
Solution
Officinae Bio provides a biological design and manufacturing platform that streamlines the creation of complex DNA and RNA constructs, enabling researchers to accelerate their work in developing advanced therapies. The platform specializes in synthesizing long, complex DNA constructs up to 10kbp, overcoming complexity limits associated with traditional manufacturing methods. For RNA therapeutics, the company leverages machine learning to optimize UTR design, enhancing translation and tissue specificity. Officinae Bio's services include gene synthesis, precision variant libraries, vector engineering, and in vitro transcription, providing researchers with ready-to-use, sequence-perfect constructs and libraries.
Target Audience
The primary audience includes researchers and biotech companies involved in developing cell and gene therapies, RNA therapeutics, and other advanced biological solutions.
Features
- DNA construct synthesis up to 10 kbp, supporting high GC content (15-85%) and long stretches of repeating sequences.
- Precision variant libraries that allow researchers to control the amino acid ratio at each position, creating diverse and fully represented mutant libraries.
- Vector engineering services for creating purpose-built vectors with customizable elements, enabling fine-tuned control over gene expression.
- Machine learning-optimized UTR design for enhanced mRNA translation and tissue specificity.
- In vitro transcription services that maximize yield and minimize dsRNA and truncated products.
- Precise length Poly A tails with defined lengths from 40 to 160 nt for full control over transcript expression.
- Quality control standards, including UV spectroscopy, capillary electrophoresis, Sanger sequencing, and NGS, to ensure DNA and RNA integrity and purity.