Twist Bioscience offers a semiconductor-based DNA synthesis platform for high-throughput, cost-effective production of custom DNA. Their technology enables rapid generation of genes, oligo pools, and variant libraries, accelerating research in synthetic biology, drug discovery, and diagnostics.
Funding
$250M raised to dateRaised to date based on public sources. This may differ from the amount the company actually raised and is based only on what is publicly available on the internet.
+2Founders
Product
Problem
The synthesis of DNA for research and development is often limited by the throughput, cost, and turnaround time of traditional methods. This can hinder the pace of discovery in fields such as synthetic biology, drug development, and diagnostics, where rapid access to custom DNA sequences is crucial.
Solution
Twist Bioscience provides a high-throughput, semiconductor-based DNA synthesis platform that enables the rapid and cost-effective production of synthetic DNA. This proprietary manufacturing process allows for the creation of custom DNA sequences, including genes, oligo pools, and variant libraries, with high accuracy and scalability. By leveraging this technology, researchers can accelerate their workflows, from basic research to the development of novel therapeutics and diagnostics. The platform supports a wide range of applications, including antibody discovery, synthetic biology, and next-generation sequencing (NGS) target enrichment.
Target Audience
Researchers and developers in biotechnology, pharmaceuticals, and academic institutions working in areas such as synthetic biology, drug discovery, antibody engineering, diagnostics, and genomics.
Features
- Proprietary semiconductor-based DNA manufacturing platform for high-throughput synthesis.
- Production of custom genes, oligo pools, and variant libraries with precise sequence control.
- Scalable synthesis capabilities to meet diverse research and development needs.
- Accelerated turnaround times for gene synthesis, including an "Express Genes" service with 4-7 business day delivery for standard complexity sequences.
- NGS validation of custom libraries to ensure diversity incorporation and uniform variant distribution.
- Support for various antibody discovery workflows, including custom library design and generation for phage display and VHH antibody discovery.
- Production of Express Genes in multiple DNA prep sizes (50 ng
- 1 mg) and vector options.
- Integrated services for antibody optimization, expression, and characterization, including CHO and HEK293 expression systems.
- Development of critical reagents and tool antibodies, such as anti-idiotypic antibodies and custom antigen production.
- Provision of NGS target enrichment solutions, including Universal Blockers to enhance specificity and on-target capture rates.