Top 50 Chemical Manufacturing in Spain

Agile Space Industries designs and manufactures in-space chemical propulsion systems using hydrazine and hydrazine-based constituents, enabling rapid development and qualification of propulsion technologies. The company addresses the need for efficient and reliable propulsion solutions in aerospace missions by conducting extensive hotfire testing and utilizing advanced in-house manufacturing techniques.

Pioneers non-precious metal catalysts and electrodes for alkaline and anion exchange membrane (AEM) electrolysis, using proprietary nanotechnology to improve efficiency and scalability in green hydrogen production. This approach reduces reliance on critical raw materials, lowers production costs by up to 20%, and supports decarbonization efforts across hard-to-abate industries.

H2SITE utilizes palladium-alloy membrane reactors to extract high-purity hydrogen from easily transportable feedstocks like ammonia and methanol, achieving over 99% purity and up to 98% recovery efficiency. The company addresses the challenge of high costs and inefficiencies in long-distance hydrogen transport, enabling small and medium enterprises to access low-carbon hydrogen more affordably.

Build to Zero provides the ThermalBox®, a modular heat‑battery system that stores renewable electricity as thermal energy and delivers 24/7 emission‑free steam below 400 °C for industrial processes. By replacing fossil‑fuel boilers, it offers continuous low‑temperature heat, reduces operating costs, and enables medium‑low temperature sectors such as chemical, food, paper, and mining to decarbonize their operations.

This startup produces alternative fats for industrial food manufacturers, utilizing oil and water emulsion gels and cultivated fat solutions to replace saturated vegetable oils and animal fats. Their products provide a sustainable source of omega-3 fatty acids, enhancing nutritional value while delivering animal flavor to food products.

The startup provides contract development and manufacturing services for lentiviral vectors, utilizing customized design and cloning tools tailored to client specifications. This enables researchers to conduct targeted tests on rare diseases and hematological cancers, facilitating advancements in gene therapy and personalized medicine.

Kemiex is a market information and eProcurement platform that provides data-driven insights for purchasing and selling raw materials in the animal and human nutrition sectors. It addresses fragmented procurement processes by centralizing supply chain management, enabling users to access independent price trends, trade flows, and a global directory of manufacturers.

Cocoon Bioscience utilizes a proprietary platform that automates the production of complex recombinant proteins and enzymes using insects in a chrysalis state, significantly reducing costs and infrastructure needs. This technology addresses the limitations of traditional bioreactor systems by providing scalable and efficient solutions for protein production in healthcare and nutrition applications.

Roka Furadada develops photo-adaptive solar molecules and biobased active ingredients that provide tailored photoprotection by transforming UV radiation into new molecular structures, enhancing sunscreen efficacy. Their technology addresses the risk of skin cancer by offering long-lasting protection that adapts to varying sunlight conditions without degrading.

Keybotic develops autonomous robot dogs for industrial inspections across sectors like Oil & Gas, Energy, and Chemicals. These robots conduct routine patrols using visual, thermal, and acoustic sensors to monitor facilities. The system uses AI for real-time hazard detection, anomaly reporting, and optimized task execution, improving safety and maintenance efficiency.

Floatech develops high-performance silicon anodes designed to significantly boost the energy storage capacity of lithium-ion batteries. Their patented process eliminates polymers and binders, enabling up to ten times the performance compared to traditional graphite anodes. This technology offers superior control over silicon expansion, leading to durable, high-efficiency battery components for advanced technology sectors.

VEnvirotech converts organic waste into biodegradable bioplastics using advanced biotechnological methods that optimize bacterial production processes. This approach addresses the significant issue of food waste, transforming it into sustainable materials that reduce reliance on petroleum-based plastics.

Senstile provides an AI Copilot specifically for material-centric industries to manage product development and material sourcing. This tool accelerates workflows by integrating functions like 3D digitization, Digital Product Passport creation, and production optimization. The platform uses multi-modal AI to enhance sustainability, improve decision-making, and significantly reduce time-to-market for new products.

Nextmol is a cloud-based platform that utilizes molecular modeling and artificial intelligence to conduct extensive in-silico testing of chemical compounds, significantly reducing the need for costly laboratory synthesis. By enabling rapid evaluation of promising molecules, Nextmol accelerates the development of high-performing and sustainable chemicals while minimizing raw material usage and waste.

Nanostine specializes in the fabrication of high-purity nanoparticles and nanostructured coatings using an ultra-high vacuum technique that ensures ligand-free surfaces and precise control over size and composition. Their technology addresses the need for advanced materials in aerospace, energy, and nanomedicine applications, providing solutions that enhance efficiency and performance without generating toxic byproducts.

JOLT develops durable, energy-efficient electrodes and electro-catalytic protective coatings for hydrogen and water treatment electrolyzers, enhancing performance and longevity beyond ten years. By providing scalable production solutions, JOLT addresses the need for cost-effective technologies that facilitate the global transition to green hydrogen.

The startup specializes in entomoculture to produce insect-based fertilizers and organic proteins for agriculture, aquaculture, and animal feed. By utilizing insect farming, the company enhances crop nutrition and promotes sustainable waste management, addressing the need for eco-friendly agricultural inputs.

Smallops produces high-quality iron nanoparticles encapsulated in carbon using hydrothermal carbonization, enabling their application in wastewater treatment, biogas production, and soil enhancement. The company transforms agricultural waste into valuable products, addressing the challenges of waste management and environmental remediation.

Residua Biocircular develops advanced processes for organic waste valorization, transforming waste into biofuels, organic fertilizers, and bio-based chemicals while minimizing landfill use and greenhouse gas emissions. By employing biotechnology and nanotechnology, the company enhances resource recovery and promotes a circular economy, ensuring maximum value extraction from organic materials.

The startup cultivates native algae on land using controlled cultivation techniques to produce high-value biomass and bioactive compounds. This process provides food, cosmetics, and nutraceutical companies with sustainable seaweed extracts that meet the growing demand for natural ingredients.

Geodesic Innovations provides chemical-free water disinfection and quality improvement systems for pools, cooling towers, and wastewater reuse networks, utilizing advanced monitoring technology to ensure optimal water conditions. The company significantly reduces chemical usage and conserves billions of liters of water, addressing the critical issues of water quality and environmental sustainability.

Macrocarbon cultivates pelagic seaweed to produce carbon-negative biomass, creating drop-in replacements for aviation fuels and plastic precursors. Their integrated approach de-risks large-scale ocean biomass production, sequestering CO2 and supporting a blue bio-economy.

This startup develops large-scale manufacturing technologies for polyurethane (PUR) products aimed at the construction sector, focusing on energy-efficient materials. By utilizing cost-effective production techniques, the company addresses the industry's need for sustainable and high-performance construction plastics.

The startup develops therapeutic compounds using a streamlined process that accelerates the transition of identified molecules from research to clinical trials. This approach addresses the lack of timely access to effective treatments for patients with limited therapeutic options.

Zymvol utilizes bioinformatics and molecular modeling to accelerate the discovery and optimization of industrial enzymes through high-throughput virtual screening and physics-based simulations. This approach reduces development time by 50% and minimizes experimental testing by up to 90%, enabling the creation of tailored biocatalysts that enhance sustainability in various industries.

Artificial Nature produces bio‑based resins and bioplastics derived from renewable feedstocks to replace petroleum‑based plastics. Their materials offer high mechanical strength, barrier performance, and customizable degradation for sectors such as agriculture, packaging, health‑and‑wellness, cosmetics, and biomedical products, enabling manufacturers to adopt sustainable, low‑carbon supply chains without sacrificing product quality.

Chlydro cultivates microalgae to produce sustainable biomass for biofertilizers and food products while capturing atmospheric CO₂ and purifying contaminated water. This technology addresses climate change, water scarcity, and food security by offering a negative carbon and water footprint solution.

Cultiply specializes in industrial microbiology and fermentation technologies to develop biological products, offering tailored bioprocess development and production services from laboratory scale to industrial manufacturing. The company addresses the need for efficient and sustainable production of high-value bioproducts, such as proteins and biofertilizers, by optimizing fermentation processes and designing custom bioreactors.

The startup produces carbon-reinforced composites using a proprietary technology that enables the continuous printing of fiber composites with various matrices. This approach enhances mechanical performance across industries, addressing the need for stronger and more durable materials in manufacturing applications.

Hysun provides off-grid solar-to-hydrogen generation systems that directly convert solar energy and water into hydrogen using a proprietary photo-thermo catalytic process. Their modular technology achieves over 56% STH efficiency, enabling scalable and cost-effective renewable hydrogen production for industries operating in remote locations.

The startup develops bioactive pharmaceutical ingredients and molecules for biomedical and dermo-cosmetic applications, utilizing molecular modeling and high throughput screening to create tailored solutions. Their services enable pharmaceutical companies to enhance drug development processes by providing customized research and sensory neurobiology platforms.

Logicmelt offers Logivision, an edge‑deployed AI vision platform that brings real‑time defect detection, component counting, operator assistance, machine anomaly monitoring, and PPE verification directly to existing industrial hardware. By running deep‑learning models on local edge devices and integrating with ERP, OPC‑UA and various camera types (thermal, high‑resolution, 3D), it delivers low‑latency, secure automation for quality, production, maintenance, and safety workflows in manufacturing.

Deduce Data Solutions builds custom, explainable AI applications for industrial and service companies to improve operational efficiency, reduce downtime, and enhance decision‑making. Their offerings include predictive maintenance, production scheduling, energy analytics, computer‑vision quality control, and demand forecasting, all integrated with existing data pipelines and control systems and supported through deployment to ongoing monitoring.

The startup develops a green technology system that utilizes biostimulants to enhance the growth and production of medicinal and aromatic compounds in plant trichomes, specifically targeting Artemisia annua. By optimizing yield and quality, the company enables medicinal plant growers to increase their commercial value.

The startup develops a software platform that automates the engineering processes of recycling and waste management plants through advanced simulation techniques tailored to various waste types. This technology enhances operational efficiency and minimizes costs by optimizing plant design and operations.

The startup manufactures cyanoacrylate adhesives specifically formulated for medical, veterinary, and cosmetic applications, providing effective wound closure and skin treatment solutions. Their products enable low-cost, efficient suturing of wounds and lacerations, enhancing patient care and recovery outcomes.

This company offers an AI-powered platform that aggregates and organizes chemical knowledge from various sources, including scientific literature and supplier catalogs. By providing a comprehensive and easily searchable database, the platform helps chemists accelerate research and development by overcoming the limitations of manual data collection.

Basquevolt develops solid-state lithium batteries utilizing a proprietary composite electrolyte, enhancing safety and sustainability for electric vehicles, heavy transport, and renewable energy applications. Their technology addresses the limitations of traditional lithium-ion batteries by enabling higher energy density and faster charging, facilitating the mass adoption of electric transportation and energy storage solutions.

The startup manufactures small-scale LNG infrastructures, including LNG, CNG, and hydrogen filling stations, as well as LNG bunker vessels and onshore import terminals. These solutions enable the reliable supply of natural gas to remote areas, addressing the challenge of energy accessibility in underserved regions.

This company develops a semiconductor nanosensor system called NanoSentry for real-time gas leak detection. The technology is designed to identify invisible fugitive emissions, including hydrogen, methane, hydrogen sulfide, and ammonia. This capability allows industries to monitor and account for various gases on-site.

7 Talos offers an AI‑driven microfluidic platform that automates and optimizes CAR‑T cell manufacturing. By integrating organ‑on‑chip bioreactors with real‑time image analysis, reinforcement‑learning control, and multi‑omics data, the system delivers standardized, cost‑effective, and personalized CAR‑T products for biopharma and research labs.

The startup develops sustainable hybrid energy storage batteries using supercapacitor-based technology combined with carbon and organic waste nanomaterials. This approach enables fast charging and extended lifespan, providing cost-effective and environmentally friendly energy storage solutions for applications in stationary storage, electric vehicles, and industrial logistics.

The startup develops natural insect repellents that utilize a proprietary technology to incorporate sugars into natural molecules, enhancing their efficacy, safety, and absorption. This approach provides a safer alternative to synthetic insect repellents, which often contain harmful chemicals and side effects.

H2Greem Global Solutions develops and manufactures proprietary PEM electrolyzers that produce up to 500 kg of hydrogen per day using renewable electricity. This technology addresses the need for sustainable hydrogen production, facilitating the transition to a low-carbon energy system while enhancing energy security through local resource utilization.

This startup develops bio-based vegan melanin using proprietary enzymatic processes, providing a cruelty-free and eco-friendly alternative to traditional melanin production methods. Their on-demand biomelanin can be integrated into food, cosmetics, and nanotechnology applications, enabling clients to meet ethical and sustainable product standards.

This startup produces bioactive compounds derived from eggshell membranes for use in the food, dietary supplement, cosmetic, nutraceutical, and pharmaceutical industries. Their multi-functional ingredients offer various health benefits, enabling companies to enhance their product formulations.

The startup is developing a high-thrust chemical propulsion system specifically designed for microsatellites, enabling rapid maneuvers in low Earth orbit (LEO). This technology addresses the need for enhanced agility and responsiveness in satellite operations, improving mission flexibility and operational efficiency.

Ozonium specializes in the distribution and installation of ozone-based systems for the disinfection and cleaning of water and air, effectively replacing harmful chemical agents. Their technology significantly reduces cleaning time and costs while enhancing safety and environmental sustainability in various industries, particularly in the food and beverage sector.

This startup produces cream liquor by utilizing distillation technology to extract unused dairy sugars from milk byproducts, converting them into carbon-neutral vodka. This process addresses the need for sustainable cocktail ingredients while minimizing waste in the dairy industry.

This company manufactures ecological fertilizers featuring activated biochar to regenerate soil health and fertility. Their products enhance water and nutrient retention, improving crop vigor and yield for various agricultural applications. The process also functions as a carbon capture method, contributing to climate sustainability.