Abfero Pharmaceuticals is developing oral iron chelators, specifically the small molecule SP-420, to treat systemic and local iron overload disorders that can lead to severe organ damage and neurodegenerative diseases. Their technology targets iron accumulation in the body, providing a safer and more tolerable treatment option for patients at risk due to transfusions or genetic conditions.

Achelios Therapeutics develops patented topical formulations that dramatically increase skin permeation of NSAIDs, enabling high‑dose delivery of anti‑inflammatory drugs directly to joints, facial tissues, and migraine sites.

Altis Biosystems develops RepliGut® Systems, a collection of in vitro models derived from human stem cells that accurately replicate the human intestinal environment for pre-clinical drug discovery. These models enable pharmaceutical companies to assess drug absorption, toxicity, and efficacy earlier in the development process, reducing reliance on animal testing and enhancing the safety and efficiency of clinical trials.

AmplifiDx develops the DX 100™ platform, a molecular point-of-care diagnostic device that utilizes advanced multiplex technology to deliver rapid and accurate test results for family and women's health. This device addresses the need for affordable and efficient diagnostics, enabling healthcare professionals and patients to obtain reliable results in under one minute with minimal hands-on time.

AOA Dx is developing GlycoLocate™, a multi-omics platform that utilizes tumor marker gangliosides for early-stage cancer detection, specifically through the AKRIVIS GD™ liquid biopsy test for ovarian cancer. This technology offers high sensitivity and specificity, addressing the critical need for effective early diagnosis in women's health.

Astrocyte Pharmaceuticals develops neuroprotective therapies targeting traumatic brain injuries, concussions, and stroke by harnessing the therapeutic potential of astrocytes and glial cells. Their approach aims to enhance brain recovery and repair mechanisms, addressing the critical need for effective treatments in a leading cause of death and disability worldwide.

Avisi Technologies is developing VisiPlate, a nanotechnology-enabled aqueous shunt designed to lower intraocular pressure in patients with open-angle glaucoma. This investigational implant addresses the risk of irreversible blindness by providing a minimally invasive solution that enhances aqueous drainage through a network of microchannels.

Basepaws offers at-home genetic testing for cats and dogs using DNA analysis to provide detailed insights into breed composition, health markers, and dental health risks. This service enables pet owners to proactively manage their pets' health by identifying genetic predispositions and informing care decisions.

Bend enhances spend data accuracy by providing precise emissions estimates for scope 3 goods and services, utilizing a robust matching system that aligns supplier and line-item data with vetted emissions factors. This enables companies to generate compliant, audit-ready GHG emission calculations and identify high-impact decarbonization opportunities.

Boardwalktech provides an AI-powered Information Intelligence Platform that unifies and organizes enterprise data from diverse structured and unstructured sources. Its low-code solutions automate processes and deliver predictive insights, enabling faster, data-driven decision-making.

The startup develops voice-based markers and methods for monitoring heart rhythm disorders in large at-risk populations using proprietary technology integrated into speech platforms like smartphones and smart speakers. This approach enables early diagnosis and preventive care, addressing the challenge of timely detection in populations vulnerable to cardiac issues.

Celero Systems is developing an ingestible system that monitors cardiac and respiratory vital signs to detect opioid overdose in real-time. This technology provides timely medication intervention without the need for wires or wearables, addressing the critical issue of opioid-related fatalities.

CNote provides a secure platform for FDIC-insured deposits and fixed income solutions, connecting investors with a vetted network of Minority Depository Institutions and Community Development Financial Institutions (CDFIs). This approach directly channels capital into underserved communities, creating jobs and supporting BIPOC-owned small businesses while promoting economic and racial justice.

The startup develops a single-use surgical device that delivers precise air pressure to a mask, maintaining open upper airway passages to treat sleep disorders such as snoring and sleep apnea. This device enables clinicians to perform turbinate reduction procedures without the need for expensive setup equipment, enhancing patient acceptance and ensuring high reimbursement rates.

Crediwatch provides a credit risk intelligence platform that automates credit assessment and continuous business monitoring using alternative data and analytics. This technology enables lenders and businesses to mitigate credit losses and identify growth opportunities by accurately evaluating borrower financial health and monitoring potential risks.

DASI Simulations offers an AI-powered platform that generates patient-specific cardiac simulations for structural heart disease procedures. This technology provides predictive visualization and automated assessments of device-anatomy interactions, enabling interventional cardiologists to optimize surgical planning and improve patient outcomes.

The startup develops surgical devices specifically designed for soft tissue surgery and hernia repair, utilizing techniques that optimize tissue tension and reinforcement. Their technology reduces tissue stress at the surgical site, minimizing the risk of surgical failure and enhancing patient outcomes.

The startup develops a network of underground tunnels for the transportation of clean renewable energy, broadband connectivity, and essential services like clean water and efficient parcel movement. This infrastructure addresses the lack of access to reliable energy and communication services in underserved communities, promoting sustainable development and connectivity.

Enduralock develops permanently locking fasteners that are highly resistant to vibration, designed for reversible and reusable applications with standard tooling. Their technology addresses the need for reliable fastener solutions in high-stress environments, such as aerospace and defense, reducing maintenance time and costs while ensuring structural integrity.

Epilogue Opus is an Enterprise Digital Adoption Platform that enables organizations to create in-application guidance and training resources for enterprise applications, streamlining user onboarding and support. By automating the generation of user assistance content and compliance documentation, it reduces training time and support tickets, enhancing user proficiency and satisfaction.

Eumentis is a biopharmaceutical company focused on developing targeted pharmacological treatments for neuropsychiatric conditions, utilizing advanced drug formulation techniques. The company aims to improve patient outcomes by addressing the unmet medical needs in the treatment of mental health disorders.

Everykey provides a universal smart key that uses proximity technology to wirelessly unlock devices and manage passwords, enhancing security through physical presence authentication. This solution mitigates the risks of phishing and unauthorized access while simplifying identity management for users and organizations.

FluidAI Medical develops the Stream™ Platform, which utilizes pH and electrical conductivity sensors to continuously monitor postoperative wound drainage for real-time analysis of anastomotic leak risk. This technology enables earlier intervention by prompting surgeons to perform diagnostic testing 80% faster than the current standard of care, significantly reducing the average detection time of gastrointestinal leaks.

Green Sun Medical is developing the Whisper Brace, a dynamic and flexible bracing technology designed to treat scoliosis by providing corrective forces while allowing for breathability and comfort. This approach aims to improve clinical outcomes, reduce treatment costs, and decrease the need for spinal fusion surgeries in children with scoliosis.