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First Spark Ventures
First Spark Ventures is a deep‑tech venture capital fund that backs breakthrough technologies aimed at making the world healthier, safer and more productive. It focuses on early‑stage companies in advanced computing, dig...
Portfolio
24+
Employees
10+
Founded
N/A
AUM
≈ $171.0M
Investment focus
Stages
Pre-Seed → Seed
Industries
Artificial IntelligenceBiotechnologyIndustrial Automation
Geographic scope
Global
Fund details
Funds
First Spark Opportunities Fund LP
Vintage 2022 • $56.5
First Spark Seed Fund LP
Vintage 2022 • $114.9
Sources
First Spark Ventures
First Spark Ventures is a deep‑tech venture capital fund that backs breakthrough technologies aimed at making the world healthier, safer and more productive. It focuses on early‑stage companies in advanced computing, digital biology & biotech and cyber‑physical systems, providing seed and pre‑seed capital to help founders translate lab innovations into market‑ready products.
Portfolio
24+
Employees
10+
Founded
N/A
AUM
≈ $171.0M
Funds
First Spark Opportunities Fund LP · Vintage 2022 • $56.5
First Spark Seed Fund LP · Vintage 2022 • $114.9
Stages
Pre-Seed → Seed
Industries
Artificial IntelligenceBiotechnologyIndustrial Automation
Geographic scope
Global
Sources
Showing 24 of 24 matched portfolio companies
Alljoined provides large‑scale deep‑learning models that translate consumer‑grade EEG and high‑resolution fMRI signals into semantic representations such as images, affective states, and mental imagery. The company releases the largest public EEG‑image dataset and a multi‑subject fMRI‑to‑image architecture that trains up to 40× faster than prior methods, supporting reproducible research and real‑time brain‑computer interface development.
The startup develops autonomous digital agents with human-like qualities, utilizing advanced computational neuroscience and machine learning techniques to create interactive experiences in gaming environments like Minecraft. By fostering empathetic and engaging digital relationships, the company addresses the growing need for companionship and productivity in an increasingly digital world.
Funding: $11.1M
Rough estimate of the amount of funding raised
Funding: $11.1M
Rough estimate of the amount of funding raised
Confidencial offers a patented selective encryption technology that automatically discovers, classifies, and protects sensitive unstructured data across on-premises and multi-cloud environments. This solution addresses the challenge of securing sensitive information while maintaining usability, ensuring compliance with industry standards like HIPAA and ISO 27001.
Funding: $3.7M
Rough estimate of the amount of funding raised
Funding: $3.7M
Rough estimate of the amount of funding raised
Curve Biosciences develops Whole-Body Intelligence models using a proprietary Whole-Body Atlas of over 400,000 curated tissue samples. These models power Whole-Body Blood Tests designed to monitor organ health in chronic disease patients. This approach aims to provide more accurate monitoring than standard methods for managing long-term health conditions.
15+
2K+Approximate amount of employees
Funding: $17.7M
Rough estimate of the amount of funding raised
Funding: $17.7M
Rough estimate of the amount of funding raised
Endometrics develops a non-invasive genomic biomarker test using menstrual blood samples for the early detection of endometriosis. This technology addresses the lengthy average diagnosis time of eight years, enabling timely intervention and improved treatment outcomes for women suffering from chronic pelvic pain and infertility.
Funding: $200.0K
Rough estimate of the amount of funding raised
Funding: $200.0K
Rough estimate of the amount of funding raised
FIGUR8 develops a bioMotion Assessment Platform (bMAP) that utilizes wearable sensor technology to provide lab-grade biomechanics data for musculoskeletal health assessments. This technology replaces subjective measurement tools, enabling precise evaluations and personalized treatment plans that enhance recovery monitoring and improve patient outcomes.
Funding: $44.1M
Rough estimate of the amount of funding raised
Funding: $44.1M
Rough estimate of the amount of funding raised
Flower provides a friendly, open-source framework for building and deploying federated learning systems. It allows users to easily integrate federated capabilities with existing machine learning projects using popular frameworks like PyTorch and TensorFlow. The platform supports enterprise-grade deployment and research into decentralized foundation model training.
Funding: $23.6M
Rough estimate of the amount of funding raised
Funding: $23.6M
Rough estimate of the amount of funding raised
Fundamental Research Labs develops autonomous, collaborative, and socially intelligent digital human agents. Their initial product, Shortcut, applies agentic reasoning to spreadsheet intelligence, acting as an AI analyst for data modeling and simulation. The company focuses on building deeply capable systems to advance human-AI collaboration.
Inlyte Energy designs and manufactures iron-sodium batteries for commercial, industrial, and utility-scale energy storage systems. These batteries utilize naturally abundant raw materials to offer a cost-effective, long-duration alternative to lithium-ion technology. The systems provide resilient, safe energy storage with a projected 20-year lifetime for daily cycling and multi-day discharge applications.
Funding: $12.6M
Rough estimate of the amount of funding raised
Funding: $12.6M
Rough estimate of the amount of funding raised
Inworld provides an AI engine that enables real-time, contextually-aware interactions in video games through dynamic non-player characters (NPCs) that learn and adapt based on player decisions. This technology enhances player immersion and engagement while streamlining game development workflows with tools for narrative and dialogue creation.
Funding: $120.0M
Rough estimate of the amount of funding raised
Funding: $120.0M
Rough estimate of the amount of funding raised
Latent AI provides an Efficient Inference Platform (LEIP) that enables enterprises to design, deploy, and manage AI models on edge devices with optimized performance and minimal resource consumption. This technology addresses the challenges of slow prototype development and high operational costs by facilitating rapid model retraining and real-time monitoring in the field.
Funding: $30.5M
Rough estimate of the amount of funding raised
Funding: $30.5M
Rough estimate of the amount of funding raised
The startup develops a capsule sampling technology that passively collects small bowel luminal fluid to generate precision datasets from the gastrointestinal tract. This approach provides healthcare providers with direct access to targeted intestinal data, enhancing the diagnosis and treatment of gastrointestinal health issues.
Funding: $3.3M
Rough estimate of the amount of funding raised
Funding: $3.3M
Rough estimate of the amount of funding raised
Normal Computing develops AI software integrated into a unified EDA platform to accelerate complex hardware engineering with zero defects. This platform enables semiconductor companies to scale new hardware development and achieve faster time-to-market. The company also offers co-designed ASICs focused on achieving near-physical limit efficiency for simulation and diffusion workloads.
Funding: $25.5M
Rough estimate of the amount of funding raised
Funding: $25.5M
Rough estimate of the amount of funding raised
Oath Surgical operates a network of multi‑specialty outpatient surgical centers that provide same‑day elective procedures with integrated anesthesia and imaging capabilities. Its cloud‑based care‑coordination platform automates referral routing, pre‑operative clearance, scheduling, post‑operative monitoring, and real‑time insurance eligibility, supporting value‑based payment models for insurers and surgeons.
Funding: $24.0M
Rough estimate of the amount of funding raised
Funding: $24.0M
Rough estimate of the amount of funding raised
Simulon provides a cloud‑native VFX platform that lets independent creators and small‑to‑mid‑size studios compose scenes in a web UI, access a library of over 1,000 assets, and render video up to 4K on demand using subscription‑based compute credits. The service eliminates the need for on‑premise hardware and software licenses, offering commercial‑grade exports with predictable monthly pricing.
SoloPulse is developing advanced sensor technology that enhances visual perception and enables higher levels of autonomy in various applications. This technology addresses the limitations of current sensing systems by providing superior safety features at a cost-effective price, facilitating rapid market adoption.
Funding: $7.2M
Rough estimate of the amount of funding raised
Funding: $7.2M
Rough estimate of the amount of funding raised
Synth Labs is developing a hybrid approach that combines Reinforcement Learning from Human Feedback (RLHF) and Reinforcement Learning from AI Feedback (RLAIF) to enhance the alignment of large language models with human preferences. This method addresses the limitations of current alignment techniques by utilizing synthetic preferences to improve model performance and scalability.
Tidal Metals extracts decarbonized magnesium metal from seawater and desalination brine using a proprietary, chemical-free process powered by renewable energy, eliminating the need for mining and waste generation. This approach addresses the environmental impact of traditional magnesium production, providing a sustainable and cost-effective supply of magnesium critical for various industries, including automotive and aerospace.
Unnatural Products utilizes an AI-enhanced discovery platform to engineer synthetic macrocycles that mimic natural macrocycles, enabling targeted therapies for complex drug targets that are typically undruggable by small molecules or biologics. This approach addresses the limitations of existing drug modalities by providing a new class of therapeutics with improved cell permeability and oral bioavailability.
Funding: $38.5M
Rough estimate of the amount of funding raised
Funding: $38.5M
Rough estimate of the amount of funding raised
Valitor employs its proprietary Multivalent Polymer (MVP) platform to conjugate multiple copies of anti‑VEGF proteins onto a custom biopolymer scaffold, creating a long‑acting ocular biologic. The lead candidate, VLTR‑559, achieves six‑month therapeutic exposure after a single intravitreal injection while maintaining potency comparable to current short‑acting agents. The modular MVP system enables rapid development of additional ophthalmic and non‑ocular macromolecular therapeutics.
Funding: $28.0M
Rough estimate of the amount of funding raised
Funding: $28.0M
Rough estimate of the amount of funding raised
Vitara Biomedical develops EXTEND, a neonatal support system that encloses extremely premature infants in a sterile, temperature‑controlled fluid‑filled environment for up to 28 days. By mimicking the fetal womb, the technology delays air exposure, allowing lungs and other organs to mature while providing continuous vital sign monitoring and automated fluid management, ultimately aiming to lower mortality and long‑term complications in NICU patients.
Funding: $50.0M
Rough estimate of the amount of funding raised
Funding: $50.0M
Rough estimate of the amount of funding raised
Walking Fish Therapeutics is developing a platform that utilizes B cell activation to enhance immune responses against diseases. This technology aims to improve therapeutic outcomes for patients with immune-related conditions by leveraging the natural capabilities of B cells.
Funding: $23.0M
Rough estimate of the amount of funding raised
Funding: $23.0M
Rough estimate of the amount of funding raised
Xona is developing the PULSAR service, a precision satellite navigation system that utilizes a constellation of low Earth orbit satellites to deliver positioning accuracy down to 2 centimeters. This technology addresses the limitations of traditional GPS by providing stronger signals that penetrate obstructions and enhance reliability in urban environments, enabling advanced applications in autonomy and AI.
Funding: $52.0M
Rough estimate of the amount of funding raised
Funding: $52.0M
Rough estimate of the amount of funding raised
Zephr provides a Local AI Platform built upon a proprietary, networked GPS solution that significantly improves positioning accuracy to sub-meter precision. Their Positioning SDK integrates raw satellite measurements and sensor fusion to deliver high-cadence, spoof-proof localization data for developers. This enhanced spatial awareness enables next-generation applications across augmented reality, autonomous systems, and precise location-based services.
Funding: $4.4M
Rough estimate of the amount of funding raised
Funding: $4.4M
Rough estimate of the amount of funding raised