Addis Energy utilizes advanced subsurface chemistry, adapted from oil and gas techniques, to convert iron-rich resources into chemical and thermal energy. The company injects engineered fluids to split water into hydrogen, which is then used to produce ammonia. This process offers a less energy-intensive and more affordable alternative to traditional ammonia manufacturing.

Anthology generates diverse, designer genomes by combining genetic parts across species boundaries to create novel biological capabilities. This technology enables the scalable and efficient production of functional proteins for human nutrition, improved animal health solutions, and carbon-neutral bioproduction from waste feedstocks. The resulting designer genomes maximize the practical impact of biology in addressing major global challenges.

Atlantic Quantum develops scalable superconducting quantum computers utilizing fluxonium qubit architecture to achieve low error rates and enable fault-tolerant quantum operations. The company addresses the challenges of high error rates and limited scalability in quantum computing, aiming to make advanced quantum technology accessible for complex computational tasks.

AtmosZero manufactures a modular electrified heat pump designed to produce industrial steam without burning fuels. This technology provides a drop-in solution for process heat applications in sectors like food and beverage, pharmaceuticals, and district heating. The system eliminates criteria pollutants and GHG emissions associated with traditional boiler operations.

Axoft develops a bio-inspired neural implant that mimics soft brain tissue to reduce drift and long-term damage while maintaining ultra-high electrode density. This device facilitates precise, single-neuron resolution communication with the nervous system for long-term interfacing. The system includes integrated signal processing electronics and specialized decoding software to manage the stable, high-volume neural data streams.

Bexorg offers the BrainEx platform, a whole‑human brain perfusion system that keeps donated post‑mortem brains metabolically active for days, allowing precise delivery of drugs, biologics, or gene therapies across an intact blood‑brain barrier. Integrated AI analyzes longitudinal omics data to produce predictive models of disease and drug response, giving pharmaceutical and biotech companies translationally relevant preclinical data to de‑risk CNS programs and accelerate therapeutic discovery.

Biobot Analytics utilizes molecular technologies and AI to analyze wastewater, providing real-time data on population health threats such as viral outbreaks and substance use. This approach enables early detection of health trends, allowing public health officials to allocate resources effectively and implement proactive harm reduction strategies.

Blue Energy manufactures and operates modular nuclear power plants, focusing on predictable cost and reliable timelines through centralized fabrication. They de-risk construction via fixed-price contracting, enabling project finance for new nuclear assets. The company sells dispatchable, baseload megawatts to industrial customers through long-term power purchase agreements.

Boston Metal offers Molten Oxide Electrolysis (MOE), an electricity‑driven, modular platform that produces steel without carbon emissions and selectively extracts high‑value ferroalloys such as niobium, tantalum, and tin from a wide range of ore grades and waste streams. The technology enables steelmakers, miners, and ferroalloy producers to decarbonize operations, convert waste into revenue, and lower operating costs while integrating with existing industrial infrastructure.

CanSense provides a rapid, non-invasive blood diagnostic technology that employs biomarker detection for the early identification of cancer. This technology enables timely cancer diagnosis, which is crucial for improving patient outcomes through earlier intervention.

Celestial AI develops the Photonic Fabric™, an optical interconnect technology that enhances data transfer speeds and reduces latency in AI computing and memory infrastructure. This technology addresses the limitations of traditional interconnects by enabling high-bandwidth, low-latency connections essential for processing extensive AI workloads efficiently.

Cellino is developing a scalable, automated biomanufacturing system that produces personalized cell therapies using patient-derived cells. This technology addresses the challenges of high costs and lengthy production times in delivering potentially curative treatments for individual patients.

Commonwealth Fusion is developing smaller, cost-effective tokamak fusion systems using high-temperature superconducting magnets to produce net energy from fusion. The company aims to deliver clean, abundant energy through its SPARC machine, paving the way for the first commercial fusion power plant, ARC, to combat climate change.

Copernic designs novel heterogeneous catalysts for zero-carbon fuels and chemicals, leveraging scientific computing tools to accelerate development. The company focuses initially on reducing the cost of zero-carbon ammonia production for fertilizers and maritime energy applications. Their solutions are engineered to be economic, rapidly scaleable, and compatible with existing chemical industry infrastructure.

DBOS provides durable workflow orchestration that makes AI systems and business logic resilient to failure through built-in observability and human-in-the-loop control. Developers integrate fault-tolerant execution and durable queues directly into existing code using simple annotations, eliminating the need for new infrastructure. The platform ensures reliable execution, automatic recovery from crashes, and real-time monitoring for complex, long-running tasks.

Droplet Biosciences has developed a platform to harvest and profile patient lymph fluid collected from surgical drains. This approach provides enhanced access to the tumor microenvironment near the surgical site for superior local assessment of cancer recurrence risk. The resulting lymph liquid biopsy enables earlier, more precise adjuvant decision-making following cancer surgery.

Emvolon converts distributed waste methane emissions into sustainable liquid fuels using modular, on-site technology. This process addresses the environmental challenge of potent methane flaring while providing necessary green fuels for hard-to-abate sectors like marine and aviation. The company enables cost-competitive decarbonization by transforming inaccessible waste streams into valuable, low-carbon energy carriers.

EVOLOH sells standardized stack modules, such as the Nautilus TM stack, designed to reduce project delays and cost overruns for Engineering, Procurement, and Construction (EPC) firms. These modules simplify plant design and integration by allowing integrators to utilize standard, widely-available Balance of Plant (BOP) components. This approach results in lower factory and stack costs compared to future competitor projections while maintaining domestic supply chains.

Foray utilizes biomanufacturing techniques to cultivate plant cells, aiming to restore and protect ecosystems threatened by the extinction of nearly 40% of plant species. By reengineering plant production, the company ensures sustainable access to essential plant-derived products, including molecules, materials, and seeds.

Form Energy develops iron-air battery systems that can store electricity for up to 100 hours, providing a cost-effective solution for multi-day energy storage. This technology addresses the need for reliable and affordable energy storage to support renewable electric grids year-round.

Foundation Alloy provides solid‑state metal processing through its proprietary MetalsFIRST™ platform, mechanically alloying raw materials without melting to produce grains up to 100× smaller. This enables the creation of next‑generation refractory and specialty alloys—such as Molyclast® molybdenum alloys—with superior strength, durability, and thermal performance for advanced manufacturing, aerospace, energy, defense, and high‑performance hardware applications.

Uses synthetic biology to enhance hyperaccumulator plants' ability to extract nickel and other metals from contaminated soils and mine tailings, enabling sustainable metal recovery in months with minimal synthetic fertilizers. This method addresses the environmental and operational challenges of traditional mining, which is slow, carbon-intensive, and often leaves land degraded for decades.

Hyfé refines plant waste to produce low-cost, low-carbon sugar and other high-value ingredients for biomanufacturing, enabling companies to replace petroleum-based feedstocks. By transforming food processing wastewater into valuable resources, Hyfé helps businesses reduce operating costs and enhance sustainability without incurring a green premium.

HyperLight develops thin-film lithium niobate photonic integrated circuits (PICs) that deliver high bandwidth and low power consumption for applications in data centers, telecommunications, and sensing. Their technology addresses the need for efficient, high-performance electro-optic solutions with minimal on-chip loss and low drive voltage, enabling advanced communication systems and sensor functionalities.