AOA Dx is developing GlycoLocate™, a multi-omics platform that utilizes tumor marker gangliosides for early-stage cancer detection, specifically through the AKRIVIS GD™ liquid biopsy test for ovarian cancer. This technology offers high sensitivity and specificity, addressing the critical need for effective early diagnosis in women's health.

Aralez Bio utilizes engineered enzymes to produce noncanonical amino acids, which are essential building blocks for peptide drugs, in a sustainable and cost-effective manner. This approach significantly reduces manufacturing time and costs, addressing the challenges of traditional amino acid production that often leads to long lead times and supply chain uncertainties.

Candesant Biomedical has developed The Brella® SweatControl Patch, which utilizes targeted alkali thermolysis (TAT) to inactivate sweat glands through a non-invasive, topical application. This solution addresses excessive sweating, impacting approximately 84 million adults in the U.S. who seek effective treatment options.

The startup offers a content licensing platform that enables users to discover and license film, photography, and audio from a diverse range of creators, including artists and hobbyists. This platform streamlines the content curation process for agencies and brands, allowing them to efficiently acquire story-driven media to enhance their marketing efforts.

Cloudamize offers a data‑centric platform that automates discovery, analysis, planning, and migration of enterprise workloads to AWS, Azure, or Google Cloud. By collecting detailed performance and configuration metrics through agent‑based and agentless scans, it generates right‑sized infrastructure recommendations, total cost of ownership comparisons, and migration roadmaps that can cut planning time by up to 75% and deliver significant cost savings.

CNote provides a secure platform for FDIC-insured deposits and fixed income solutions, connecting investors with a vetted network of Minority Depository Institutions and Community Development Financial Institutions (CDFIs). This approach directly channels capital into underserved communities, creating jobs and supporting BIPOC-owned small businesses while promoting economic and racial justice.

Collate provides an AI-driven platform that automates the creation and management of regulatory documentation for diagnostic, medical device, and drug development projects. The solution streamlines preclinical and clinical trial paperwork, quality management, and change control to reduce errors and accelerate timelines. By handling documentation tasks, it enables life‑science teams to focus on research and bring products to market faster.

Cooler Heads has developed Amma™, a portable scalp cooling system that lowers scalp temperature during chemotherapy to reduce hair loss by limiting the absorption of chemotherapy drugs in hair follicles. This FDA-cleared device allows patients to self-administer treatment anywhere in the infusion center, providing a practical solution for maintaining their identity and mental well-being during cancer treatment.

CreditEnable operates a managed digital marketplace for SME finance, utilizing proprietary data analytics and AI to optimize lending decisions and enhance borrower access to credit. The platform addresses the inefficiencies in SME lending by providing quick eligibility assessments and streamlined loan processes, enabling loans up to £15 million at competitive rates.

Full Harvest offers an AI‑driven marketplace that instantly matches fresh produce buyers with growers, providing real‑time pricing, availability, and automated compliance with traceability regulations. The platform automates procurement workflows, reduces manual effort, and continuously learns to improve sourcing efficiency and reduce food waste across the North American supply chain.

Goalsetter offers a digital financial education platform that delivers standards‑aligned, AI‑personalized curricula for K‑12 schools, colleges, financial advisors, and banks. The mobile‑first solution combines video lessons, interactive games, and quizzes with auto‑grading, reporting dashboards, and integration tools to help institutions meet literacy mandates and drive actionable financial habits.

Harvest Thermal develops a Smart Thermal Battery that integrates heating, hot water, and cooling systems using an air-to-water heat pump and thermal storage technology. This system reduces home energy consumption by up to 90% and lowers energy bills by 30%, addressing the high emissions and costs associated with traditional gas furnaces.

Hire an Esquire is a SaaS marketplace that matches law firms and corporate legal departments with a vetted pool of contract attorneys and paralegals. The platform uses automated bar‑status verification and an AI‑driven matching engine to deliver practice‑area specific candidates, and provides integrated tools for posting, interviewing, contract issuance, and payroll processing.

Mae connects expectant mothers with community-based doulas and dedicated care coordinators to provide personalized support throughout pregnancy and postpartum. The platform integrates with health insurance plans to facilitate access to evidence-based maternal health resources and education. This integrated approach aims to improve maternal health outcomes, including reductions in preterm birth and C-section rates.

ORNA is an AI‑powered, cloud‑based platform that unifies threat detection, incident triage, response orchestration, and post‑incident reporting for security teams. By integrating with EDR, XDR, and SIEM tools, it de‑duplicates alerts into actionable incidents, provides AI‑generated playbooks, and automates detailed compliance reporting, helping organizations reduce response times and streamline breach management.

Pallet constructs rapid-response shelter villages that provide transitional housing for individuals experiencing homelessness, featuring 24/7 case management and essential services. By creating safe, dignified living environments, Pallet facilitates the transition from unsheltered living to permanent housing, while allowing residents to stay with their partners and pets.

Rally is a bus rideshare platform that connects passengers to shared transportation for events, utilizing a crowd-powered model to fill buses efficiently. This service addresses the challenge of high transportation costs and limited access to event venues by providing a convenient and eco-friendly travel option.

RenovoRx offers a Trans-Arterial Micro-Perfusion (TAMP™) therapy platform that delivers oncology agents directly to solid tumors via the peripheral vascular system. This targeted approach, utilizing the FDA-cleared RenovoCath® device, aims to increase drug concentration at the tumor site while potentially reducing systemic toxicities.

TBTM operates as a Media FinTech platform that converts cultural engagement into tangible value for creators, fans, and brands. The company utilizes a blockchain-based social video platform to issue the Kola Digital Reward Token for interactions with content. Its interactive projects, such as the docu-series *Take Back the Mic*, leverage this technology to allow fans to curate and influence programming.

Terviva cultivates pongamia trees to produce sustainable oil and protein food ingredients, utilizing patented high-yielding varieties and proprietary bean processing methods. This approach revitalizes degraded farmland, enhances soil health, and supports local communities while addressing the need for climate-resilient agricultural solutions.

Tivic Health develops ClearUP, a non-invasive bioelectronic device that uses low-current electrical stimulation to target sinus nerve pathways, providing drug-free relief from sinus pain, headaches, and congestion. This clinically proven solution offers rapid symptom relief without the side effects associated with traditional medications, making it a preferred choice for over 100,000 users.

Zenflow is developing a minimally invasive procedure for treating benign prostatic hyperplasia (BPH) that eliminates the need for burning, cutting, or piercing tissue, resulting in minimal bleeding. Clinical studies indicate that patients experience significant symptom relief and recover within hours, offering a patient-friendly alternative to traditional BPH treatments.