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2048 Ventures
New York, United States
2048 Ventures is a thesis‑driven early‑stage VC firm based in New York and Boston that leads pre‑seed and seed rounds with $500K‑$2M checks. The firm focuses on vertical AI, deep‑tech, health and biotech startups that bu...
Portfolio
30+
Employees
40+
Founded
2018
AUM
≈ $94.0M
Investment focus
Stages
Pre-Seed → Seed
Industries
Artificial IntelligenceBiotechnologyHealthcare Technology
Geographic scope
United States
Fund details
Funds
Fund II
Vintage 2022 • $67.0M
Fund I
Vintage 2019 • $27.0M
Check sizes
Min: $500.0K
Typical: $1.3M
Max: $2.0M
Sources
2048 Ventures
2048 Ventures is a thesis‑driven early‑stage VC firm based in New York and Boston that leads pre‑seed and seed rounds with $500K‑$2M checks. The firm focuses on vertical AI, deep‑tech, health and biotech startups that build defensibility through data, infrastructure and platform moats. It seeks companies creating systems of record, APIs and data‑driven solutions that can become long‑term competitive advantages.
Portfolio
30+
Employees
40+
Founded
2018
AUM
≈ $94.0M
Funds
Fund II · Vintage 2022 • $67.0M
Fund I · Vintage 2019 • $27.0M
Check Sizes
Min: $500.0K
Typical: $1.3M
Max: $2.0M
Stages
Pre-Seed → Seed
Industries
Artificial IntelligenceBiotechnologyHealthcare Technology
Geographic scope
United States
Sources
Showing 24 of 30 matched portfolio companies
Aclid is a biotechnology security and compliance automation platform that provides real-time screening of gene synthesis orders and automatic verification of customer licenses and biosafety guidelines. This technology reduces the risk of misuse and streamlines compliance processes, enabling biotech manufacturers to minimize order cancellations and delays.
Funding: $3.6M
Rough estimate of the amount of funding raised
Funding: $3.6M
Rough estimate of the amount of funding raised
Aerodome develops Drone-As-First-Responder technology that enables rapid drone deployment to emergency incidents within three minutes, utilizing automated response systems and remote operations without visual observers. This technology enhances public safety by providing real-time aerial support for law enforcement, wildfire prevention, and search and rescue missions.
Funding: $21.5M
Rough estimate of the amount of funding raised
Funding: $21.5M
Rough estimate of the amount of funding raised
Aslan provides a centralized dashboard for managing and monitoring security operations. The platform aggregates data from various security tools to offer unified visibility into threat landscapes. This enables security teams to streamline incident response and maintain compliance posture efficiently.
Basis Health provides an AI practice management operating system specifically designed for longevity and concierge care clinics. This platform automates administrative tasks, streamlines data analysis from integrated sources like wearables and labs, and enhances patient interaction workflows. The system enables practices to scale client capacity while delivering personalized care protocols and managing integrated services like lab ordering and payment processing.
BioBox Analytics is a biological search engine that integrates multi-modal biological data through automatic metadata harmonization across over 50 biomedical ontologies, enabling real-time identification of significant data points. This technology reduces the time spent on data cleaning and enhances the ability to make informed decisions by systematically ranking associations based on comprehensive evidence.
Funding: $930.0K
Rough estimate of the amount of funding raised
Funding: $930.0K
Rough estimate of the amount of funding raised
Bridge is a SaaS platform that embeds intro request links into collaboration tools such as Notion, Airtable, or email, enabling a no‑login, double‑opt‑in workflow for warm introductions. It automates consent collection, email dispatch from the introducer’s address, and follow‑up reminders, while AI tags each intro for reporting and integrates via API, Zapier, and webhooks for KPI tracking.
Develops scalable biocatalysis solutions that produce essential chemicals from sustainable carbon sources using engineered enzymes and whole-cell catalysts. This process reduces reliance on fossil fuels and enables environmentally friendly manufacturing by optimizing catalyst performance and integrating with existing production systems.
Century Health offers an AI‑driven platform that extracts and structures real‑world clinical data directly from electronic health records, creating research‑ready registries without disrupting provider workflows. The solution enables researchers and biopharma to query curated, disease‑specific datasets through a web analytics dashboard, accelerating evidence generation for drug development and regulatory submissions while allowing providers to retain data ownership and earn revenue shares.
Funding: $2.0M
Rough estimate of the amount of funding raised
Funding: $2.0M
Rough estimate of the amount of funding raised
This startup offers an AI-native operating system that integrates with existing POS systems to analyze store data alongside over 150 external factors, such as weather and local events, to optimize inventory management. By providing precise product recommendations and automated ordering, it helps convenience retailers maintain stock levels, reduce waste, and enhance customer satisfaction.
Funding: $2.1M
Rough estimate of the amount of funding raised
Funding: $2.1M
Rough estimate of the amount of funding raised
Enurgen provides a cloud-based software solution, DUET, that optimizes bifacial solar system design by analyzing dual-sided energy generation and shading effects in real time. This technology enables solar operators to enhance energy yield and reduce system faults, streamlining the planning process from days to minutes.
Funding: $1.0M
Rough estimate of the amount of funding raised
Funding: $1.0M
Rough estimate of the amount of funding raised
Flare provides an AI‑driven, cloud‑based finance platform that consolidates accounting, payments, expense management, and fundraising for nonprofit organizations. The solution offers business banking, corporate cards, automated bill‑pay, and real‑time dashboards that integrate with existing accounting software to streamline reconciliations and track restricted donor funds.
Funding: $120.0K
Rough estimate of the amount of funding raised
Funding: $120.0K
Rough estimate of the amount of funding raised
Flare provides an AI-powered financial platform that automates accounting, expense management, and fundraising for nonprofit organizations, enabling them to manage their financial operations efficiently. By consolidating financial data into a single source of truth, Flare eliminates reconciliation issues and enhances real-time financial insights, allowing nonprofits to maximize their impact.
The startup offers an automated personal assistant software that manages appointments, bookings, and payments for beauty professionals and freelancers. By streamlining client management and providing analytics, the software enhances client engagement and marketing efforts, enabling users to efficiently grow their businesses.
Funding: $70.6M
Rough estimate of the amount of funding raised
Funding: $70.6M
Rough estimate of the amount of funding raised
Gybe provides a water quality monitoring platform that integrates satellite imagery and ground sensor data to deliver near real-time analytics on parameters such as turbidity and chlorophyll-a across entire water bodies. This technology enables catchment management teams to efficiently track and assess the health of aquatic ecosystems, addressing the challenge of sparse and time-consuming water quality data collection.
Funding: $120.0K
Rough estimate of the amount of funding raised
Funding: $120.0K
Rough estimate of the amount of funding raised
Provides an IoT-enabled analytics platform that integrates hardware and machine learning to optimize industrial liquid and fluid systems. By ingesting over 1 million data points per second, it identifies inefficiencies and delivers real-time recommendations, reducing water usage by 11% per week and cutting cleaning cycle downtime by 18% within six weeks.
Funding: $6.9M
Rough estimate of the amount of funding raised
Funding: $6.9M
Rough estimate of the amount of funding raised
Kanary Copilot automates online safety actions to protect users from doxxing and digital stalking through a privacy-focused application. The platform enables individuals to manage their digital identities securely and efficiently from their devices.
Funding: $895.0K
Rough estimate of the amount of funding raised
Funding: $895.0K
Rough estimate of the amount of funding raised
KiraGen Bio develops off-the-shelf, donor-derived CAR-T cell therapies utilizing multiplex precision gene editing. Their technology is designed to create robust cell therapies with intrinsic resilience against the tumor microenvironment (TME). This approach aims to deliver durable function for treating challenging indications like Glioblastoma Multiforme (GBM).
PainWorth is an AI-driven legal services application that automates the calculation and settlement of personal injury claims by analyzing thousands of similar legal cases. The platform empowers injury victims to quickly assess their compensation and negotiate settlements without the need for traditional legal representation.
Funding: $1.7M
Rough estimate of the amount of funding raised
Funding: $1.7M
Rough estimate of the amount of funding raised
The startup operates a career opportunity platform that connects educational institutions, employers, and financial organizations to create accessible pathways for immigrants and individuals with limited financial resources. By integrating educational and job opportunities, the platform addresses the barriers to education and employment faced by these underserved populations.
Funding: $30.0M
Rough estimate of the amount of funding raised
Funding: $30.0M
Rough estimate of the amount of funding raised
PathSpot provides a cloud‑native health and safety operating system that combines a handheld hand‑contamination scanner with real‑time analytics. The scanner detects residual microbes and chemicals after hand washing and sends results to a secure cloud platform that generates threshold alerts, anomaly detection and actionable recommendations via SMS, email or app, while a dashboard offers hierarchical reporting and API integration with POS and HACCP systems.
Persist AI accelerates drug formulation discovery by integrating an AI platform with high-throughput robotics in a cloud lab environment. This system allows scientists to design experiments remotely, which are then executed automatically to rapidly screen and predict formulations matching a target product profile. The company supports the entire process from initial discovery through to commercial cGMP manufacturing and analytical testing.
Funding: $4.5M
Rough estimate of the amount of funding raised
Funding: $4.5M
Rough estimate of the amount of funding raised
Psyrin provides frontier AI for behavioral health, automating patient intake and documentation processes to increase clinical efficiency. Their platform, Mira, collects pre-appointment information and generates AI insights to support clinicians before and between patient visits. This technology standardizes assessment quality and reduces administrative burden, improving overall capacity in mental healthcare delivery.
Funding: $1.0M
Rough estimate of the amount of funding raised
Funding: $1.0M
Rough estimate of the amount of funding raised
Ready Practice provides a single SaaS platform that combines electronic health records, scheduling, telehealth, payment processing, and patient acquisition tools for outpatient clinics. Its AI Copilot extracts data from lab results, suggests care protocols and billing codes, and the system integrates wearable data and automated workflows to streamline clinical operations and marketing.
Ripple is an AI-powered platform that enables brands and agencies to create visually appealing marketing emails in minutes, eliminating the need for design skills. By automating the email design process and integrating with email service providers, Ripple significantly reduces the time and resources required for effective email marketing campaigns.
Funding: $20.0K
Rough estimate of the amount of funding raised
Funding: $20.0K
Rough estimate of the amount of funding raised