Top 50 Chemical Manufacturing - Series B

Chemify is a platform that digitizes chemistry and chemical discovery by executing chemical code for drug discovery, synthesis, and materials development. This technology accelerates the synthesis of complex molecules and enables the creation of extensive functional libraries, enhancing reproducibility and efficiency in molecular optimization.

Helios is developing sustainable chemical processes that utilize renewable feedstocks to produce essential materials with reduced environmental impact. The company focuses on minimizing pollution and resource depletion in manufacturing across various industries.

MSTACK is a B2B platform that utilizes real-time tracking and streamlined documentation to facilitate efficient chemical sourcing for global companies. By leveraging a vast network, MSTACK reduces procurement costs by 10-25% while ensuring consistent quality through rigorous testing in certified laboratories.

Syzygy Plasmonics develops a photocatalytic reactor that utilizes light to produce hydrogen and syngas from low-carbon-intensity feedstocks, eliminating the need for combustion in chemical production. This technology addresses the high carbon emissions associated with traditional fossil fuel-based chemical processes, enabling a more sustainable and cost-effective approach to fuel production.

The startup manufactures a chemical process technology that converts renewable feedstocks, such as glycerol, into acrylonitrile and acetonitrile, providing a sustainable alternative to fossil-based production. This approach significantly reduces carbon emissions and enhances safety while offering competitive pricing in the chemical market.

This company develops microbial and biosurfactant production systems for creating environmentally friendly and biodegradable microbes. Their modular facilities enable businesses to reduce their carbon footprint through customizable and sustainable solutions.

The startup provides contract development and manufacturing services for the pharmaceutical and biotechnology sectors, focusing on late-stage clinical and commercial liquid and lyophilized filling. By facilitating the transition from clinical development to commercial launch, the company addresses the need for reliable production capabilities in drug discovery and pharmaceutical development.

Allozymes utilizes proprietary microfluidics technology to rapidly engineer and optimize custom enzymes, significantly increasing the speed of development and success rates in enzyme production. This approach addresses the environmental impact of traditional manufacturing methods by providing cleaner, more efficient biocatalytic processes for producing natural ingredients.

Aether Bio develops machine learning algorithms and proprietary robotic hardware to engineer enzymes for the production of complex biochemical compounds. This technology enables manufacturers to create novel products at significantly reduced costs by efficiently indexing and searching trillions of enzyme sequences.

Phlow utilizes U.S.-based advanced manufacturing processes to produce essential medicines, focusing on the development of Active Pharmaceutical Ingredients (APIs) and Finished Drug Products (FDPs) to enhance domestic supply chain resilience. The company addresses vulnerabilities in the global pharmaceutical supply chain by ensuring reliable access to critical medications and reducing costs through streamlined production.

Knowde is an online marketplace that connects businesses with over 230,000 chemicals and raw ingredients from more than 8,000 suppliers, facilitating the sourcing process through direct communication and streamlined transactions. The platform addresses the challenge of ingredient procurement by providing instant access to product catalogs, samples, and quotes, enabling faster decision-making for industries such as healthcare, agriculture, and consumer goods.

Valdera is a sourcing platform that utilizes AI and machine learning to automate supplier discovery and engagement for chemicals and raw materials, enabling buyers to efficiently find qualified suppliers without manual searches. The platform addresses challenges in supply chain management by streamlining procurement processes, reducing costs, and providing real-time market insights.

This company offers a software platform for life sciences and manufacturing companies to manage quality and risk across their entire value chain. Their platform helps automate repetitive and complex tasks, from sourcing to manufacturing to supply chain management, improving overall efficiency and compliance.

The startup provides outsourced pharmaceutical manufacturing services focused on compounded sterile injectables, including antibiotics and anesthetics, in ready-to-use unit dose forms. This enables hospitals and long-term care facilities to efficiently access critical medications while ensuring compliance with stringent safety and quality standards.

Albert is an end-to-end cloud platform that integrates electronic lab notebooks (ELN), laboratory information management systems (LIMS), and AI-driven formulation optimization to streamline research and development in the chemical and materials science industry. By digitalizing workflows and enhancing collaboration, Albert enables chemists to accelerate product development cycles by over 50% while maintaining 99.5% inventory accuracy.

The company manufactures specialty pharmaceutical products that enhance patient outcomes by focusing on targeted therapeutic areas. It specializes in the acquisition, development, and marketing of these products to address specific medical needs in the healthcare market.

Again utilizes a bioreactor to capture carbon dioxide emissions and ferment them into carbon-negative chemicals, providing a method to reduce greenhouse gas levels. This technology enables emitters to achieve carbon neutrality while supplying manufacturers with sustainable chemical alternatives.

The startup develops production monitoring software that processes raw manufacturing data to provide real-time insights into production metrics. This technology helps manufacturers minimize resource waste and enhance operational efficiency.

Aralez Bio utilizes engineered enzymes to produce noncanonical amino acids, which are essential building blocks for peptide drugs, in a sustainable and cost-effective manner. This approach significantly reduces manufacturing time and costs, addressing the challenges of traditional amino acid production that often leads to long lead times and supply chain uncertainties.

The startup operates a contract manufacturing organization that specializes in aseptic fill and finish services for injectable drugs, utilizing unidirectional process flows and electronic batch records. This ensures that pharmaceutical companies can produce medical products in a controlled and sterile environment, minimizing contamination risks.

The startup develops machine-learning tools to design cell factories capable of producing a wide range of products, including food, fabrics, and medicines. By simplifying the complex process of cellular manufacturing, the company aims to replace traditional farms and factories, promoting a more sustainable production model.

NobleAI provides a cloud-based platform that utilizes Science-Based AI to accelerate the development of materials and chemicals by enabling rapid formulation and optimization. The platform addresses the lengthy and costly process of product innovation, allowing companies to create safe and sustainable products in minutes rather than months.

21st Bio develops sustainable bio-based alternatives to replace traditional meals and materials, utilizing advanced fermentation processes and strain optimization for high product yield and stability. The company addresses the need for environmentally friendly solutions in food and material production, enabling businesses to reduce their ecological footprint while maintaining quality.

Constructive.Bio utilizes a dual-technology platform that combines de novo genome synthesis and engineered translation to create programmable biomolecules with high fidelity. This approach addresses the limitations of traditional biomanufacturing by enabling the production of customized bioproducts, including phage-resistant strains and next-generation therapeutics.

Nucleus RadioPharma is a contract development and manufacturing organization CDMO that specializes in building clinical and commercial supply chains for targeted radiotherapies, utilizing advanced manufacturing infrastructure and regulatory expertise. The company addresses the bottlenecks in the production and delivery of radiopharmaceuticals, ensuring timely access to life-saving treatments for patients.

Checkerspot utilizes a proprietary WING® Platform to optimize microbes for the biomanufacturing of structural oils, providing sustainable alternatives to petroleum-based materials. This technology enables industries to develop high-performance products while reducing reliance on fossil fuels and meeting environmental standards.

The startup designs and manufactures bio-material fabrics using proprietary technologies for sustainable treatments and dyes, targeting the environmental impact of the apparel and consumer goods industries. By providing eco-friendly material alternatives, the company enables customers to reduce their ecological footprint while fulfilling their product needs.

Colorifix utilizes a biological process to engineer microorganisms that produce and fix pigments onto textiles, eliminating the need for harmful chemicals in dyeing. This method significantly reduces environmental impact while maintaining high-quality color standards in the fashion and textiles industry.

Insempra utilizes precision fermentation to produce 100% bio-based ingredients for the beauty, food, and fashion industries, reducing reliance on petrochemicals and conventional agricultural practices. This technology addresses environmental degradation and resource depletion by offering sustainable alternatives that maintain high quality and stability.

This startup operates as a contract development and manufacturing organization, providing services such as injectable drug formulation development, analytical method development, and process scale-up for biopharmaceutical partners. By offering formulation and filling of vials, syringes, and cartridges, the company enables faster production of medications to meet clinical and commercial demands in the healthcare industry.

PiLi biofabricates sustainable, biosourced colorants using industrial fermentation and organic chemistry to replace fossil fuel-derived pigments in various applications, including textiles and inks. This approach significantly reduces CO₂ emissions and addresses the environmental impact of the color industry, which currently relies heavily on non-renewable resources.

OPT Industries provides a vertically integrated digital manufacturing platform that utilizes additive manufacturing and computational design to produce highly customized consumer products with micron-scale precision. By streamlining the process from concept to mass production, the company addresses the challenges of traditional manufacturing limitations and lengthy supply chains.

The startup operates a network for plastic production companies, utilizing automated systems and correlative molding processes to manufacture customized rigid and molded plastic products. This approach addresses the need for efficient, high-quality production in the healthcare, consumer packaged goods, and light industrial sectors.

RedoxBlox develops thermochemical energy storage (TCES) units that store energy as heat and chemical energy at temperatures up to 1,500°C, providing a scalable alternative to fossil fuels for industrial processes. Their technology offers higher energy density than lithium-ion batteries, enabling decarbonized industrial heat and grid-scale storage at a lower cost.

Molten Industries produces clean hydrogen and graphite for U.S. manufacturing sectors, including steel and batteries, utilizing advanced electrolysis and carbon capture technologies. This approach directly addresses the high carbon emissions associated with traditional hydrogen production, promoting a sustainable and decarbonized hydrogen market.

The startup has developed a purification and disinfection device that generates hydrogen peroxide using only water, air, and electricity, producing an eco-friendly biocide. This technology enhances food and water safety while minimizing the environmental impact and risks associated with transporting and handling toxic disinfectants.

Atomic Industries develops an AI-powered tool and die maker that automates the design and production of manufacturing components. This technology significantly reduces lead times and costs associated with traditional manufacturing processes, enhancing efficiency in the production of goods.

The startup has developed a non-thermal metal 3D printing technology that utilizes electroplating, eliminating the need for metal powders, vacuum chambers, and lasers. This process reduces manufacturing costs and enhances material quality while allowing for safe disposal of used salt cartridges.

RXC develops a next-generation media commerce platform that utilizes advanced data analytics and machine learning to enhance brand visibility and engagement. The platform addresses the challenge of ineffective brand promotion by providing targeted marketing solutions that drive measurable sales growth.

Cellibre utilizes precision fermentation and strain engineering to transform cells into sustainable production systems for high-value products, addressing the environmental impact of traditional manufacturing methods. By optimizing microbial biochemistry, the company enables the large-scale, eco-friendly production of essential ingredients, such as cannabinoids, while minimizing reliance on resource-intensive agricultural practices.

Multiscale Technologies utilizes AI-driven simulations and high-throughput testing through its MIND platform and SMaRT machine to accelerate materials design and manufacturing processes. This approach significantly reduces time to market and material waste while enhancing quality control and cost efficiency for product companies across various industries.

Loa Carbon synthesizes circular hydrocarbons and solid carbon materials from captured carbon dioxide using a patented manufacturing process powered by zero-emission energy. This technology reduces reliance on fossil fuels by providing sustainable products at price parity with the cheapest fossil-based alternatives.

Provides a digital inventory and manufacturing platform that connects SMBs with a global network of over 500 vendors across 25 countries, streamlining product development, sourcing, and supply chain management. By offering inventory financing and integrated project management tools, it reduces manufacturing costs, shortens production timelines, and enables businesses to scale by adding new products and suppliers efficiently.

Bota Bio utilizes synthetic biology and enzyme engineering to produce high-quality bio-preservatives and nutritional supplements from renewable resources, significantly reducing raw material and energy consumption. Their technology addresses the demand for sustainable solutions in the food and personal care industries by replacing petroleum-based processes with efficient biomanufacturing methods.

Debut combines biotechnology with brand development to create sustainable beauty products using eco-friendly active ingredients. The company addresses the environmental impact of traditional cosmetics by offering climate-positive solutions that enhance consumer well-being.

Cemvita utilizes engineered microbes to convert waste products, such as CO2, into valuable compounds, effectively closing the carbon loop in industrial processes. By transforming emissions into useful materials and recovering essential metals like lithium and copper, Cemvita addresses the environmental impact of heavy industries while promoting sustainable resource management.

Hygenco develops and operates modular Green Hydrogen and Green Ammonia production facilities, utilizing proprietary simulation technology and IoT for real-time operational optimization. The company addresses the need for cost-effective, scalable clean energy solutions across various industries, aiming to produce 75,000 tonnes of Green Hydrogen annually by 2026.

Exothera is a contract development and manufacturing organization (CDMO) specializing in GMP manufacturing services for viral vectors and RNA therapeutics, utilizing fixed bed and stirred tank bioprocessing technologies. The company addresses the need for efficient and scalable production solutions in the development of vaccines and gene therapies, ensuring high yields and quality from pre-clinical stages to commercial readiness.

This company designs and builds custom automation systems for manufacturing, including assembly lines and plastic processing machinery. Their mechatronic solutions help manufacturers increase productivity, improve efficiency, and achieve greater precision in their operations.

Tidal Vision manufactures chitosan-based biomolecular solutions using its proprietary Chitofining™ Process and Zale Technology™ to address water treatment and agricultural challenges. Their products enhance efficiency and reduce environmental impact by providing high-concentration, zero-waste alternatives to traditional chemical solutions.