Top 50 Chemical Manufacturing - Series B

The startup manufactures a chemical process technology that converts renewable feedstocks, such as glycerol, into acrylonitrile and acetonitrile, providing a sustainable alternative to fossil-based production. This approach significantly reduces carbon emissions and enhances safety while offering competitive pricing in the chemical market.

The startup develops a closed-loop neural network platform that utilizes deep hydrocarbon processing expertise to create precise models for complex refinery and chemical plant operations. This technology enables operators to identify and capitalize on new process optimization opportunities, enhancing efficiency and profitability in their facilities.

Syzygy Plasmonics develops a photocatalytic reactor that utilizes light to produce hydrogen and syngas from low-carbon-intensity feedstocks, eliminating the need for combustion in chemical production. This technology addresses the high carbon emissions associated with traditional fossil fuel-based chemical processes, enabling a more sustainable and cost-effective approach to fuel production.

Albert is an end-to-end cloud platform that integrates electronic lab notebooks (ELN), laboratory information management systems (LIMS), and AI-driven formulation optimization to streamline research and development in the chemical and materials science industry. By digitalizing workflows and enhancing collaboration, Albert enables chemists to accelerate product development cycles by over 50% while maintaining 99.5% inventory accuracy.

The startup develops fermentation technology that utilizes gravity separation to recover insoluble lipids during the biosurfactant production process. This method provides businesses with an environmentally friendly alternative to traditional surfactants, addressing the need for sustainable chemical solutions.

Mitra Chem develops iron-based cathode materials for lithium-ion batteries, utilizing machine learning to streamline research and manufacturing processes, reducing the lab-to-production timeline by over 90%. The company addresses the underdeveloped North American battery materials supply chain, which is critical for achieving clean energy goals and reducing reliance on foreign sources.

Lygos creates bio‑inspired, biodegradable, water‑soluble specialty chemicals that replace traditional petrochemical additives in agronomy, home‑care, personal‑care, and water‑treatment formulations. Their flagship polymer, Soltellus™, improves cleaning performance, formulation stability, and cost efficiency while offering a commercial‑scale, integrated supply chain and full technical documentation for rapid product development.

Valdera is an AI-powered digital sourcing platform connecting buyers and suppliers for chemicals and raw materials. The platform automates supplier discovery, qualification, and engagement to streamline procurement processes. It helps businesses diversify supply chains, reduce costs, and manage market volatility in the chemical industry.

The startup develops catalytic methanation reactors that utilize dielectric barrier discharge to convert gaseous reactants into gaseous or liquid products. This technology enhances the efficiency of biogas and pyrolysis processes, enabling industries to optimize their production and reduce operational costs.

Phlow Corp. is a U.S.-based contract development and manufacturing organization that offers integrated small‑molecule API development, analytical support, and scalable cGMP production on a single campus. Its facilities provide flexible kilo‑scale batches for preclinical and clinical work as well as metric‑ton‑scale lines for commercial manufacturing, reducing lead times and enhancing supply‑chain security for pharmaceutical companies and government agencies.

Talus develops modular, containerized green ammonia systems for local, on-site production. This technology provides agriculture, industrial, and energy sectors with a cost-competitive and reliable supply of essential raw materials. By eliminating long supply chains, the company stabilizes costs and enhances supply certainty for end-users.

Synata Bio develops a fermentation technology that converts synthesis gas from various waste sources into low-carbon ethanol and circular chemicals. This process effectively repurposes waste carbon emissions, reducing CO2 output by two tons for every ton of product produced, while supporting the transition to sustainable fuel and chemical production.

M2X Energy provides end-to-end solutions to convert waste methane from sources like landfills into biomethanol. Their modular, fast-deploy systems offer a scalable path to low-carbon fuel for the shipping, energy, and chemical manufacturing sectors. This service allows partners to monetize methane emissions while accelerating the transition to cleaner energy resources.

The startup operates a contract manufacturing organization that specializes in aseptic fill and finish services for injectable drugs, utilizing unidirectional process flows and electronic batch records. This ensures that pharmaceutical companies can produce medical products in a controlled and sterile environment, minimizing contamination risks.

NobleAI provides a cloud-based platform that utilizes Science-Based AI to accelerate the development of materials and chemicals by enabling rapid formulation and optimization. The platform addresses the lengthy and costly process of product innovation, allowing companies to create safe and sustainable products in minutes rather than months.

OXCCU develops a patented one-step catalytic process that converts carbon dioxide and hydrogen from renewable sources into low carbon intensity fuels, chemicals, and biodegradable plastics. This technology addresses the need for sustainable hydrocarbons in aviation and consumer products, significantly reducing capital and operational costs compared to traditional methods.

This startup operates as a contract development and manufacturing organization, providing services such as injectable drug formulation development, analytical method development, and process scale-up for biopharmaceutical partners. By offering formulation and filling of vials, syringes, and cartridges, the company enables faster production of medications to meet clinical and commercial demands in the healthcare industry.

Chemify is a platform that digitizes chemistry and chemical discovery by executing chemical code for drug discovery, synthesis, and materials development. This technology accelerates the synthesis of complex molecules and enables the creation of extensive functional libraries, enhancing reproducibility and efficiency in molecular optimization.

Molten Industries develops proprietary technology for the on-demand production of high-purity graphite and clean hydrogen directly from natural gas. This process bypasses traditional high-emission methods, offering a lower-carbon pathway for essential material sourcing. The company provides a sustainable alternative for industries requiring both carbon materials and hydrogen fuel.

The startup specializes in chemical recycling services for post-use plastics, transforming difficult-to-recycle materials into valuable feedstock for new plastic production. By connecting waste collectors with recyclers, the company effectively diverts plastic waste from landfills and mitigates environmental pollution.

Mura Technology employs a proprietary chemical recycling process to convert plastic waste into its original monomers, facilitating the production of new plastics without relying on virgin materials. This method significantly reduces plastic waste in landfills and decreases the carbon emissions associated with conventional plastic manufacturing.

MSTACK is a B2B platform that utilizes real-time tracking and streamlined documentation to facilitate efficient chemical sourcing for global companies. By leveraging a vast network, MSTACK reduces procurement costs by 10-25% while ensuring consistent quality through rigorous testing in certified laboratories.

Stargate Hydrogen Solutions provides turn-key alkaline electrolysis systems for the production of green hydrogen using renewable energy sources. Their technology addresses the need for decarbonization in industries such as heavy transport and steelmaking, where traditional electrification methods are insufficient.

INERATEC provides modular Power‑to‑X plants that convert captured CO₂ and renewable hydrogen into carbon‑neutral synthetic fuels (e‑diesel, e‑SAF, e‑naphtha, e‑wax) and high‑purity e‑chemicals.

DeepCure utilizes its Inspired Chemistry™ platform for automated chemical synthesis to develop small molecule therapies targeting autoimmune diseases, including rheumatoid arthritis and atopic dermatitis. By collaborating with leading researchers, the company aims to enhance drug discovery efficiency and expand treatment options for patients with immune-related conditions.

Wabash Valley Resources produces anhydrous ammonia fertilizer using hydrogen generated through a zero-carbon process, significantly reducing carbon emissions associated with traditional fertilizer production. This approach addresses the reliance on imported fertilizers while capturing and storing approximately 1.65 million tons of CO2 annually, enhancing energy security and supporting sustainable agriculture in the U.S. Corn Belt.

Westwin Elements operates America’s only Class 1 nickel refinery, producing ≥99.9% pure carbonyl nickel powder, nickel briquettes, and battery‑grade nickel sulfate on U.S. soil. By delivering domestically refined, low‑emission, and ESG‑compliant nickel, the company reduces import dependency and provides a reliable, traceable supply for manufacturers of alloys, batteries, 3D‑printed components, aerospace, and other high‑purity nickel applications.

Via Separations develops proprietary membrane materials that reduce energy consumption in thermal separations by up to 90%, enhancing efficiency in industrial processes. Their technology addresses the significant energy demands of manufacturing sectors such as pulp and paper, chemicals, and refining, delivering substantial cost savings and operational flexibility.

Knowde is an online marketplace that connects businesses with over 230,000 chemicals and raw ingredients from more than 8,000 suppliers, facilitating the sourcing process through direct communication and streamlined transactions. The platform addresses the challenge of ingredient procurement by providing instant access to product catalogs, samples, and quotes, enabling faster decision-making for industries such as healthcare, agriculture, and consumer goods.

LanzaTech utilizes gas fermentation technology to convert industrial waste carbon emissions into sustainable fuels, chemicals, and materials. This process directly addresses the challenge of carbon pollution by transforming harmful emissions into valuable resources, contributing to a circular economy.

cusp.ai provides a cloud‑based AI platform that generates and evaluates candidate materials using generative deep‑learning models combined with physics‑informed property predictors. The system offers high‑throughput virtual screening, active‑learning loops that incorporate experimental data, and API/SDK access for seamless integration into R&D and manufacturing workflows, enabling faster identification of high‑performance compounds.

Checkerspot utilizes a proprietary WING® Platform to optimize microbes for the biomanufacturing of structural oils, providing sustainable alternatives to petroleum-based materials. This technology enables industries to develop high-performance products while reducing reliance on fossil fuels and meeting environmental standards.

The startup has developed a purification and disinfection device that generates hydrogen peroxide using only water, air, and electricity, producing an eco-friendly biocide. This technology enhances food and water safety while minimizing the environmental impact and risks associated with transporting and handling toxic disinfectants.

Again utilizes a bioreactor to capture carbon dioxide emissions and ferment them into carbon-negative chemicals, providing a method to reduce greenhouse gas levels. This technology enables emitters to achieve carbon neutrality while supplying manufacturers with sustainable chemical alternatives.

EmpressTX offers the Chemilogics™ platform, which uses human genetic data, AI/ML, and co‑evolutionary algorithms to generate drug‑like small molecules that are naturally encoded in the genome. By predicting and prioritizing millions of chemically diverse candidates and enabling rapid synthetic‑biology production, the platform reduces lead‑identification timelines from years to months, providing pharmaceutical and biotech companies with biologically validated starting points for drug development.

The startup manufactures medicinal oils and active ingredients derived from plant matrices using ultrasonic extraction technology, which enhances the bioavailability of therapeutic compounds. This process provides users with effective natural remedies for various health conditions, improving overall well-being.

Lyten develops and manufactures supermaterials based on its proprietary 3D Graphene™ platform, which captures carbon from methane and produces clean hydrogen. Its product line includes lithium‑sulfur batteries (LytCell™), graphene‑infused polyethylene composites (LytR™), and concrete additives that deliver higher energy density, reduced weight, and lower carbon footprints for EVs, aerospace, construction, and plastics manufacturers.

Aralez Bio utilizes engineered enzymes to produce noncanonical amino acids, which are essential building blocks for peptide drugs, in a sustainable and cost-effective manner. This approach significantly reduces manufacturing time and costs, addressing the challenges of traditional amino acid production that often leads to long lead times and supply chain uncertainties.

Terray Therapeutics offers an end‑to‑end platform that automates the design, synthesis, and testing of small‑molecule drug candidates using custom hardware, real‑time data capture, and proprietary AI models. By integrating experimental feedback with machine‑learning predictions, the system accelerates hit‑to‑lead cycles and expands accessible chemical space for pharmaceutical and biotech researchers.

AIR COMPANY utilizes its proprietary AIRMADE™ technology to convert carbon dioxide and water into carbon-negative chemicals and sustainable aviation fuel through a modular, scalable process powered by renewable energy. This approach directly addresses climate change by transforming greenhouse gas emissions into valuable resources for various industries.

Syntetica utilizes green chemistry and chemical depolymerization to create sustainable synthetic textiles, starting with nylon. Their process effectively separates raw materials from blended nylon textile waste, a capability traditional recycling methods lack. This technology enables the full circularity of Nylon 6 and Nylon 6,6 streams for industrial use.

Bota Bio utilizes synthetic biology and enzyme engineering to produce high-quality bio-preservatives and nutritional supplements from renewable resources, significantly reducing raw material and energy consumption. Their technology addresses the demand for sustainable solutions in the food and personal care industries by replacing petroleum-based processes with efficient biomanufacturing methods.

Tidal Vision manufactures chitosan-based biomolecular solutions using its proprietary Chitofining™ Process and Zale Technology™ to address water treatment and agricultural challenges. Their products enhance efficiency and reduce environmental impact by providing high-concentration, zero-waste alternatives to traditional chemical solutions.

Cemvita utilizes engineered microbes to convert waste products, such as CO2, into valuable compounds, effectively closing the carbon loop in industrial processes. By transforming emissions into useful materials and recovering essential metals like lithium and copper, Cemvita addresses the environmental impact of heavy industries while promoting sustainable resource management.

Everfuel produces green hydrogen by electrolyzing water, enabling a clean energy source for mobility and industrial applications. The company aims to significantly reduce greenhouse gas emissions in hard-to-abate sectors, supplying up to 8 tons of green hydrogen daily to customers across Europe.

Sublime Systems utilizes an electrified manufacturing process to produce low-carbon cement, eliminating the energy-intensive kiln traditionally used in cement production. This technology significantly reduces CO₂ emissions while providing a drop-in replacement for conventional cement, ensuring compatibility with existing construction practices.

ElectraLith develops a direct lithium extraction and refining technology that produces battery-grade lithium hydroxide in a single, modular process without the use of water or chemicals. This method addresses the environmental impact of traditional lithium production by utilizing renewable energy, enhancing sustainability in lithium supply chains.

Brimstone develops a decarbonized process for producing ordinary portland cement that meets ASTM C150 standards, significantly reducing CO2 emissions associated with cement production. Their technology aims to eliminate 120,000 metric tons of CO2 annually, addressing the cement industry's contribution to 7.5% of global CO2 emissions.

Epsilyte manufactures engineered expandable polystyrene (EPS) resin for North American customers in construction, packaging, foodservice, medical, automotive casting and safety applications. Its product portfolio includes high‑R‑value insulation, fire‑retardant, recycled‑content and biodegradable grades, with domestic production and technical support to ensure fast delivery, consistent quality, and sustainable performance.

Exothera is a contract development and manufacturing organization (CDMO) specializing in GMP manufacturing services for viral vectors and RNA therapeutics, utilizing fixed bed and stirred tank bioprocessing technologies. The company addresses the need for efficient and scalable production solutions in the development of vaccines and gene therapies, ensuring high yields and quality from pre-clinical stages to commercial readiness.