Top 50 Chemical Manufacturing - Series B

The startup manufactures a chemical process technology that converts renewable feedstocks, such as glycerol, into acrylonitrile and acetonitrile, providing a sustainable alternative to fossil-based production. This approach significantly reduces carbon emissions and enhances safety while offering competitive pricing in the chemical market.

Helios is developing sustainable chemical processes that utilize renewable feedstocks to produce essential materials with reduced environmental impact. The company focuses on minimizing pollution and resource depletion in manufacturing across various industries.

Syzygy Plasmonics develops a photocatalytic reactor that utilizes light to produce hydrogen and syngas from low-carbon-intensity feedstocks, eliminating the need for combustion in chemical production. This technology addresses the high carbon emissions associated with traditional fossil fuel-based chemical processes, enabling a more sustainable and cost-effective approach to fuel production.

Synata Bio develops a fermentation technology that converts synthesis gas from various waste sources into low-carbon ethanol and circular chemicals. This process effectively repurposes waste carbon emissions, reducing CO2 output by two tons for every ton of product produced, while supporting the transition to sustainable fuel and chemical production.

Mura Technology employs a proprietary chemical recycling process to convert plastic waste into its original monomers, facilitating the production of new plastics without relying on virgin materials. This method significantly reduces plastic waste in landfills and decreases the carbon emissions associated with conventional plastic manufacturing.

Loa Carbon synthesizes circular hydrocarbons and solid carbon materials from captured carbon dioxide using a patented manufacturing process powered by zero-emission energy. This technology reduces reliance on fossil fuels by providing sustainable products at price parity with the cheapest fossil-based alternatives.

OXCCU develops a patented one-step catalytic process that converts carbon dioxide and hydrogen from renewable sources into low carbon intensity fuels, chemicals, and biodegradable plastics. This technology addresses the need for sustainable hydrocarbons in aviation and consumer products, significantly reducing capital and operational costs compared to traditional methods.

Again utilizes a bioreactor to capture carbon dioxide emissions and ferment them into carbon-negative chemicals, providing a method to reduce greenhouse gas levels. This technology enables emitters to achieve carbon neutrality while supplying manufacturers with sustainable chemical alternatives.

Wabash Valley Resources produces anhydrous ammonia fertilizer using hydrogen generated through a zero-carbon process, significantly reducing carbon emissions associated with traditional fertilizer production. This approach addresses the reliance on imported fertilizers while capturing and storing approximately 1.65 million tons of CO2 annually, enhancing energy security and supporting sustainable agriculture in the U.S. Corn Belt.

Molten Industries produces clean hydrogen and graphite for U.S. manufacturing sectors, including steel and batteries, utilizing advanced electrolysis and carbon capture technologies. This approach directly addresses the high carbon emissions associated with traditional hydrogen production, promoting a sustainable and decarbonized hydrogen market.

Mitra Chem develops iron-based cathode materials for lithium-ion batteries, utilizing machine learning to streamline research and manufacturing processes, reducing the lab-to-production timeline by over 90%. The company addresses the underdeveloped North American battery materials supply chain, which is critical for achieving clean energy goals and reducing reliance on foreign sources.

The startup develops fermentation technology that utilizes gravity separation to recover insoluble lipids during the biosurfactant production process. This method provides businesses with an environmentally friendly alternative to traditional surfactants, addressing the need for sustainable chemical solutions.

Chemify is a platform that digitizes chemistry and chemical discovery by executing chemical code for drug discovery, synthesis, and materials development. This technology accelerates the synthesis of complex molecules and enables the creation of extensive functional libraries, enhancing reproducibility and efficiency in molecular optimization.

Hygenco develops and operates modular Green Hydrogen and Green Ammonia production facilities, utilizing proprietary simulation technology and IoT for real-time operational optimization. The company addresses the need for cost-effective, scalable clean energy solutions across various industries, aiming to produce 75,000 tonnes of Green Hydrogen annually by 2026.

The startup develops a closed-loop neural network platform that utilizes deep hydrocarbon processing expertise to create precise models for complex refinery and chemical plant operations. This technology enables operators to identify and capitalize on new process optimization opportunities, enhancing efficiency and profitability in their facilities.

Manufactures high-throughput electrochemical stack modules for hydrogen production, utilizing standardized balance-of-plant components to eliminate the need for custom power electronics or fluid management systems. This approach reduces electrolyzer stack costs by 10x compared to future projections, streamlines plant design with standardized integration, and addresses the critical supply chain and scalability challenges faced by current electrolyzer technologies.

M2X Energy Inc. develops modular, transportable gas-to-liquids systems that convert stranded methane into low-carbon methanol using a patented non-catalytic, partial-oxidation reformer. This technology addresses the challenge of methane emissions from flaring and waste sectors by providing a scalable solution for producing methanol, which can be utilized as marine fuel, chemical feedstock, and a hydrogen carrier.

Aether Bio develops machine learning algorithms and proprietary robotic hardware to engineer enzymes for the production of complex biochemical compounds. This technology enables manufacturers to create novel products at significantly reduced costs by efficiently indexing and searching trillions of enzyme sequences.

Canvass AI provides an industrial AI platform that enables oil and gas, chemical, and manufacturing companies to optimize production processes and asset management through real-time predictive analytics and actionable insights. The technology addresses inefficiencies by minimizing unplanned downtime and enhancing product quality, resulting in significant cost savings and reduced environmental impact.

Phlow utilizes U.S.-based advanced manufacturing processes to produce essential medicines, focusing on the development of Active Pharmaceutical Ingredients (APIs) and Finished Drug Products (FDPs) to enhance domestic supply chain resilience. The company addresses vulnerabilities in the global pharmaceutical supply chain by ensuring reliable access to critical medications and reducing costs through streamlined production.

Albert is an end-to-end cloud platform that integrates electronic lab notebooks (ELN), laboratory information management systems (LIMS), and AI-driven formulation optimization to streamline research and development in the chemical and materials science industry. By digitalizing workflows and enhancing collaboration, Albert enables chemists to accelerate product development cycles by over 50% while maintaining 99.5% inventory accuracy.

Clean Hydrogen Works develops a low-cost and reliable process for producing clean ammonia through an integrated hydrogen value chain. This technology addresses the need for sustainable ammonia production, which is essential for reducing carbon emissions in agriculture and energy sectors.

Haber provides a real-time automation platform that utilizes AI-driven algorithms and robotic sampling to monitor and control process, utilities, and water systems. This technology enhances operational efficiency by reducing chemical consumption, minimizing variability, and improving output quality in industrial settings.

The startup develops catalytic methanation reactors that utilize dielectric barrier discharge to convert gaseous reactants into gaseous or liquid products. This technology enhances the efficiency of biogas and pyrolysis processes, enabling industries to optimize their production and reduce operational costs.

LanzaTech utilizes gas fermentation technology to convert industrial waste carbon emissions into sustainable fuels, chemicals, and materials. This process directly addresses the challenge of carbon pollution by transforming harmful emissions into valuable resources, contributing to a circular economy.

The startup operates a contract manufacturing organization that specializes in aseptic fill and finish services for injectable drugs, utilizing unidirectional process flows and electronic batch records. This ensures that pharmaceutical companies can produce medical products in a controlled and sterile environment, minimizing contamination risks.

Aralez Bio utilizes engineered enzymes to produce noncanonical amino acids, which are essential building blocks for peptide drugs, in a sustainable and cost-effective manner. This approach significantly reduces manufacturing time and costs, addressing the challenges of traditional amino acid production that often leads to long lead times and supply chain uncertainties.

General Graphene specializes in industrial-scale production of high-quality chemical vapor deposition (CVD) graphene and carbon materials using proprietary roll-to-roll technology. The company provides researchers and industries with a reliable and scalable supply of graphene, addressing the need for affordable materials in applications ranging from flexible electronics to healthcare.

Anovion Technologies manufactures synthetic graphite anode material for lithium-ion batteries using a high-temperature graphitization process that ensures low impurities and high crystallinity. This production capability addresses the critical need for a secure, domestic supply chain of battery materials in North America, supporting electric vehicle and aerospace applications.

The startup develops a technology that processes methane into hydrogen and solid carbon without emitting carbon dioxide, utilizing a method that separates methane into its elemental components. This approach enables industries to convert natural gas or biogas into clean hydrogen fuel and high-quality carbon, addressing the need for sustainable energy sources and reducing greenhouse gas emissions.

Checkerspot utilizes a proprietary WING® Platform to optimize microbes for the biomanufacturing of structural oils, providing sustainable alternatives to petroleum-based materials. This technology enables industries to develop high-performance products while reducing reliance on fossil fuels and meeting environmental standards.

DeepCure utilizes its Inspired Chemistry™ platform for automated chemical synthesis to develop small molecule therapies targeting autoimmune diseases, including rheumatoid arthritis and atopic dermatitis. By collaborating with leading researchers, the company aims to enhance drug discovery efficiency and expand treatment options for patients with immune-related conditions.

Chemix utilizes a GenAI platform to accelerate the design of electric vehicle batteries, reducing development time by tenfold while eliminating the use of cobalt and minimizing reliance on nickel and lithium. This approach enables seamless integration with existing lithium-ion manufacturing processes, facilitating a faster transition from research and development to mass production.

The startup specializes in upcycling hard-to-recycle plastics, such as bags and packaging, into performance materials by chemically transforming post-consumer polyethylene into thermoplastic polyurethane (TPU) building blocks. This process enables brands and manufacturers to achieve sustainability targets while maintaining product quality and reducing their carbon footprint.

Sublime Systems utilizes an electrified manufacturing process to produce low-carbon cement, eliminating the energy-intensive kiln traditionally used in cement production. This technology significantly reduces CO₂ emissions while providing a drop-in replacement for conventional cement, ensuring compatibility with existing construction practices.

AIR COMPANY utilizes its proprietary AIRMADE™ technology to convert carbon dioxide and water into carbon-negative chemicals and sustainable aviation fuel through a modular, scalable process powered by renewable energy. This approach directly addresses climate change by transforming greenhouse gas emissions into valuable resources for various industries.

NobleAI provides a cloud-based platform that utilizes Science-Based AI to accelerate the development of materials and chemicals by enabling rapid formulation and optimization. The platform addresses the lengthy and costly process of product innovation, allowing companies to create safe and sustainable products in minutes rather than months.

Lygos produces bio‑manufactured specialty polymers, including the Soltellus™ family, from renewable sugars and CO₂. These biodegradable, water‑soluble polymers act as performance boosters, super‑absorbents, and scale inhibitors for agronomy, home‑care, hygiene, personal‑care, and water‑treatment formulations, enabling customers to replace persistent chemicals without sacrificing efficacy or cost. Lygos also supplies technical documentation and collaborative formulation support to accelerate product development.

GRST Holdings develops water-based lithium-ion battery manufacturing and recycling technology that eliminates toxic solvents and significantly reduces energy consumption. This approach addresses the environmental impact of traditional battery production and enhances the recyclability of batteries, supporting a circular economy in energy storage.

Cellibre utilizes precision fermentation and strain engineering to transform cells into sustainable production systems for high-value products, addressing the environmental impact of traditional manufacturing methods. By optimizing microbial biochemistry, the company enables the large-scale, eco-friendly production of essential ingredients, such as cannabinoids, while minimizing reliance on resource-intensive agricultural practices.

Advanced Ionics develops electrolyzers that operate in an intermediate temperature range, utilizing existing steam in industrial settings to produce green hydrogen with up to 50% less electricity per kilogram. This technology eliminates the green premium associated with hydrogen production, making it more cost-effective for industries reliant on hydrogen for exothermic reactions.

iM3NY manufactures lithium-ion battery cells using proprietary phosphate-based chemistry that offers 10-20% better energy density than standard LFP cells while maintaining lower costs than NMC cells. The company addresses the need for sustainable energy solutions in electric vehicles and stationary energy storage by producing batteries with a significantly reduced carbon footprint at its Gigafactory in Endicott, NY.

Stargate Hydrogen Solutions provides turn-key alkaline electrolysis systems for the production of green hydrogen using renewable energy sources. Their technology addresses the need for decarbonization in industries such as heavy transport and steelmaking, where traditional electrification methods are insufficient.

Via Separations develops proprietary membrane materials that reduce energy consumption in thermal separations by up to 90%, enhancing efficiency in industrial processes. Their technology addresses the significant energy demands of manufacturing sectors such as pulp and paper, chemicals, and refining, delivering substantial cost savings and operational flexibility.

PiLi biofabricates sustainable, biosourced colorants using industrial fermentation and organic chemistry to replace fossil fuel-derived pigments in various applications, including textiles and inks. This approach significantly reduces CO₂ emissions and addresses the environmental impact of the color industry, which currently relies heavily on non-renewable resources.

Tidal Vision manufactures chitosan-based biomolecular solutions using its proprietary Chitofining™ Process and Zale Technology™ to address water treatment and agricultural challenges. Their products enhance efficiency and reduce environmental impact by providing high-concentration, zero-waste alternatives to traditional chemical solutions.

Cemvita utilizes engineered microbes to convert waste products, such as CO2, into valuable compounds, effectively closing the carbon loop in industrial processes. By transforming emissions into useful materials and recovering essential metals like lithium and copper, Cemvita addresses the environmental impact of heavy industries while promoting sustainable resource management.

Versogen develops a scalable anion exchange membrane (AEM) electrolyzer that utilizes water and renewable energy to produce green hydrogen, addressing the need for zero-emission solutions in hard-to-abate industries. By employing earth-abundant materials, the technology offers a reliable and cost-effective method to significantly reduce industrial carbon emissions.

This startup operates as a contract development and manufacturing organization, providing services such as injectable drug formulation development, analytical method development, and process scale-up for biopharmaceutical partners. By offering formulation and filling of vials, syringes, and cartridges, the company enables faster production of medications to meet clinical and commercial demands in the healthcare industry.

The startup provides contract development and manufacturing services for the pharmaceutical and biotechnology sectors, focusing on late-stage clinical and commercial liquid and lyophilized filling. By facilitating the transition from clinical development to commercial launch, the company addresses the need for reliable production capabilities in drug discovery and pharmaceutical development.