Top 50 Chemical Manufacturing - Series A

This startup is a distributor of chemicals that facilitates cross-border trade through a proprietary digital order management platform, enhancing supply chain reliability and turnaround times. By providing quality assurance and personal account management, the company enables global chemical buyers to find new raw material sources while allowing sellers to access new markets without incurring additional costs.

Anodyne utilizes enzymatic processes to convert CO2 into carbon negative chemicals, addressing the high greenhouse gas emissions and energy consumption of the traditional chemicals industry. Their technology operates at room temperature with zero emissions and low utility costs, providing safe and efficient production of essential low carbon products.

Aepnus Technology utilizes ultra-efficient electrolysis to produce electrified chemicals, such as hydrochloric acid and sulfuric acid, from renewable electricity, significantly reducing production costs and emissions. This process addresses the need for sustainable domestic manufacturing of critical minerals and chemicals, enhancing the U.S. supply chain for battery production and recycling.

Helios is developing sustainable chemical processes that utilize renewable feedstocks to produce essential materials with reduced environmental impact. The company focuses on minimizing pollution and resource depletion in manufacturing across various industries.

The startup develops a cloud-based computational chemistry platform that utilizes advanced chemical simulations to streamline the design and testing of chemical and pharmaceutical products. By providing a user-friendly interface and robust security features, the platform accelerates product development while ensuring data integrity.

MSTACK is a B2B platform that utilizes real-time tracking and streamlined documentation to facilitate efficient chemical sourcing for global companies. By leveraging a vast network, MSTACK reduces procurement costs by 10-25% while ensuring consistent quality through rigorous testing in certified laboratories.

The startup develops a de-fossilized technology that utilizes mixed plastic waste and CO2 as feedstock to produce syngas, which serves as a foundational component for manufacturing chemicals like plastics, methanol, and hydrogen. This approach enables chemical producers to reduce their dependence on fossil resources, such as natural gas, while enhancing the quality of their chemical outputs.

EV Biotech develops microbial cell factories that utilize synthetic biology techniques for the industrial production of chemicals and proteins. This approach addresses the need for sustainable and efficient manufacturing processes in the chemical and biotechnology sectors.

Bluestem Biosciences utilizes programmable biology for the biomanufacturing of commodity chemicals, focusing on sustainable production methods that leverage existing agricultural infrastructure in the Midwest. The company addresses the reliance on fossil fuels by creating a decarbonized chemical platform that enhances domestic supply chains and supports agricultural economies.

The startup specializes in green chemical manufacturing by utilizing computational chemistry and digitalization to enhance the sustainability of pharmaceutical production. Their technology enables the efficient reuse of resources and precise monitoring of chemical processes, resulting in reduced environmental impact and improved production quality.

The startup manufactures a chemical process technology that converts renewable feedstocks, such as glycerol, into acrylonitrile and acetonitrile, providing a sustainable alternative to fossil-based production. This approach significantly reduces carbon emissions and enhances safety while offering competitive pricing in the chemical market.

This company develops microbial and biosurfactant production systems for creating environmentally friendly and biodegradable microbes. Their modular facilities enable businesses to reduce their carbon footprint through customizable and sustainable solutions.

FabricNano develops cell-free biomanufacturing processes that utilize biocatalysts and natural materials to produce sustainable products. This technology addresses the environmental impact of traditional manufacturing by enabling efficient, eco-friendly production methods.

This company develops metal-organic frameworks that selectively capture hazardous materials from various industrial processes. Their platform enables clients in sectors like chemicals and electronics to achieve sustainability goals by removing dangerous substances with precision.

Catalyxx Inc. utilizes patented thermo-chemical catalytic technology to convert bioethanol, derived from CO2-captured sugars, into high-value chemicals with a negative carbon footprint. This process addresses the reliance on fossil fuels in chemical production by providing a competitive, biogenic alternative that reduces CO2 emissions by 3.5 kg per kg of bio-based chemical produced.

FluoRok utilizes patented fluorination technology to produce fluorochemicals without the use of toxic hydrofluoric acid, significantly enhancing safety and sustainability in the manufacturing process. This approach addresses the environmental and health risks associated with traditional fluorochemical production methods, offering a cleaner and more cost-effective solution for various industries.

Allozymes utilizes proprietary microfluidics technology to rapidly engineer and optimize custom enzymes, significantly increasing the speed of development and success rates in enzyme production. This approach addresses the environmental impact of traditional manufacturing methods by providing cleaner, more efficient biocatalytic processes for producing natural ingredients.

novoMOF synthesizes and produces metal-organic frameworks (MOFs), a class of advanced materials with diverse applications. They provide custom MOF solutions for various industries, enabling advancements in gas storage, catalysis, and separation technologies.

Enzymit develops a cell-free bioproduction platform utilizing computational protein design and high-throughput testing to create novel enzymes for various industries, including biochemicals and health. This technology addresses the inefficiencies and high costs associated with traditional enzymatic manufacturing processes, enabling faster and more sustainable production.

Entalpic utilizes a generative AI platform to discover new catalysts that optimize chemical reactions while considering physicochemical and manufacturing constraints. This approach addresses the need for more sustainable materials and processes in the chemical industry.

The startup provides manufacturing services that validate engineering designs and prototype new products through small batch-to-volume production and box-build processes. By integrating design files with a network of manufacturing methods, the company enables businesses to efficiently scale and localize production in response to growth and digitization needs.

Synonym develops biomanufacturing infrastructure and a dynamic database of contract manufacturers to facilitate the commercialization of next-generation bioproducts. By providing techno-economic analysis and lifecycle assessments, the company helps businesses scale production efficiently while addressing the challenges of supply chain sustainability and decarbonization.

Circe has developed a gas fermentation platform that converts carbon dioxide, water, and electricity into nature-identical organic molecules, enabling the production of essential products across various industries. This process not only achieves price parity with traditional methods but also removes 3 kilograms of CO₂ for every kilogram of product generated, addressing the urgent need for sustainable manufacturing solutions.

Dunia Innovations accelerates the discovery of electroactive materials for the chemical industry by utilizing robotics and advanced algorithms, reducing research and development timelines from 20 years to just 2 years. This technology enables the production of cost-effective green chemicals and fuels, addressing the urgent need for material innovation to achieve net-zero emissions.

This company offers a software platform for life sciences and manufacturing companies to manage quality and risk across their entire value chain. Their platform helps automate repetitive and complex tasks, from sourcing to manufacturing to supply chain management, improving overall efficiency and compliance.

SepPure Technologies develops solvent-resistant nanofiltration membranes that separate chemical mixtures at the molecular level, significantly reducing energy consumption in industrial processes. Their technology addresses the high energy intensity and pollution associated with traditional chemical separation methods, with potential annual savings of one million tonnes of volatile organic compounds and one billion tonnes of carbon dioxide.

Albert is an end-to-end cloud platform that integrates electronic lab notebooks (ELN), laboratory information management systems (LIMS), and AI-driven formulation optimization to streamline research and development in the chemical and materials science industry. By digitalizing workflows and enhancing collaboration, Albert enables chemists to accelerate product development cycles by over 50% while maintaining 99.5% inventory accuracy.

Cauldron Ferm utilizes a proprietary hyper-fermentation technology to enable continuous fermentation processes that significantly increase productivity and reduce manufacturing costs by up to 50% compared to traditional fed-batch methods. This technology addresses the challenges of high production costs and capital requirements in biomanufacturing, facilitating the transition from lab-scale to commercial-scale production for precision fermentation products.

Again utilizes a bioreactor to capture carbon dioxide emissions and ferment them into carbon-negative chemicals, providing a method to reduce greenhouse gas levels. This technology enables emitters to achieve carbon neutrality while supplying manufacturers with sustainable chemical alternatives.

The startup develops production monitoring software that processes raw manufacturing data to provide real-time insights into production metrics. This technology helps manufacturers minimize resource waste and enhance operational efficiency.

Antheia utilizes synthetic biology to manufacture biosynthetic Key Starting Materials (KSMs) and Active Pharmaceutical Ingredients (APIs) for essential medicines, enhancing the reliability and efficiency of pharmaceutical supply chains. This approach mitigates the risks of drug shortages caused by unpredictable agricultural sources and environmental factors.

Aralez Bio utilizes engineered enzymes to produce noncanonical amino acids, which are essential building blocks for peptide drugs, in a sustainable and cost-effective manner. This approach significantly reduces manufacturing time and costs, addressing the challenges of traditional amino acid production that often leads to long lead times and supply chain uncertainties.

Chromatic develops the RX-AM™ platform, which utilizes chemical reactions to 3D print industrial-strength elastomeric parts without the need for melting or post-processing. This technology enables manufacturers to produce durable, customizable components on various substrates, reducing costs and waste associated with traditional injection molding methods.

Nemo Nanomaterials develops and manufactures industrial additives using advanced nanoparticle dispersion techniques to enhance the performance and properties of various materials. Their solutions address the need for cost-effective improvements in material functionality, enabling industries to innovate and meet evolving demands.

NobleAI provides a cloud-based platform that utilizes Science-Based AI to accelerate the development of materials and chemicals by enabling rapid formulation and optimization. The platform addresses the lengthy and costly process of product innovation, allowing companies to create safe and sustainable products in minutes rather than months.

Brilliant Matters develops and manufactures organic semiconductors using proprietary chemical processes for printed electronics applications, including organic solar cells and photodetectors. The company addresses the need for a reliable supply of high-quality materials that support the commercialization of sustainable energy technologies.

The startup manufactures electrolyte solutions for energy storage technologies, specializing in lithium-ion batteries, sodium-ion batteries, and supercapacitors. Their products enable clients to meet specific energy storage requirements while enhancing performance and efficiency in various applications.

The startup develops bio-based packaging materials using green processing technology that eliminates toxic chemicals, providing sustainable alternatives to single-use plastics. Their compostable food packaging products offer organizations a measurable reduction in environmental impact compared to conventional plastic options.

Dioxycle develops modular electrolyzer technology that transforms carbon dioxide emissions into sustainable ethylene, a key feedstock for various everyday products. This process enables the recycling of over 800 million tons of CO₂ annually, significantly reducing reliance on fossil fuel-derived ethylene.

Citrine Informatics accelerates materials and chemicals development with an AI-powered platform that unifies data and enables virtual experimentation. Its tools predict material properties and optimize product design, streamlining R&D and reducing time to market.

The startup develops sterile injectable drug products, including prefilled syringes and vials, to address the issue of drug shortages in healthcare settings. By minimizing the resources required for medication preparation and administration, the company enhances operational efficiency for hospitals, outpatient centers, and clinics.

Pow.bio has developed a high-efficiency fermentation platform that decouples biomass growth from product production, addressing issues of contamination and genetic drift in biomanufacturing. This technology enables manufacturers to achieve 2-5 times more product output while reducing production costs by 40-70%.

Swedish Algae Factory cultivates diatoms to extract high-tech silica shells, known as Algica, which replace harmful chemicals in organic personal care products and enhance solar panel efficiency. This process captures significant amounts of CO2, nitrogen, and phosphorus, contributing to a sustainable and circular production model.

Ruby Bio utilizes a proprietary biosynthesis platform that employs naturally occurring yeast to convert low-cost sugar into biodegradable and non-toxic molecules for various industries. This technology provides sustainable alternatives for personal care, food, and industrial applications, enabling companies to transition to environmentally friendly ingredients while optimizing performance and cost.

This startup develops AI and large language model (LLM) tools specifically for the design and manufacturing sectors, utilizing advanced AI and computer graphics to enhance engineering productivity. By streamlining the design and manufacturing process, the company enables enterprises to significantly lower costs and accelerate project timelines.

Provides an AI-powered troubleshooting platform for chemical processing plants that detects operational anomalies and exceeds alarm thresholds before they cause unplanned downtime. By analyzing live and historical data, it enables frontline teams to identify trends, collaborate on resolutions, and reduce costly disruptions with targeted alerts and proactive insights.

Colorifix utilizes a biological process to engineer microorganisms that produce and fix pigments onto textiles, eliminating the need for harmful chemicals in dyeing. This method significantly reduces environmental impact while maintaining high-quality color standards in the fashion and textiles industry.

Insempra utilizes precision fermentation to produce 100% bio-based ingredients for the beauty, food, and fashion industries, reducing reliance on petrochemicals and conventional agricultural practices. This technology addresses environmental degradation and resource depletion by offering sustainable alternatives that maintain high quality and stability.

The startup develops a synthetic biology plant architecture that utilizes proprietary hyper-integration algorithms and precision fermentation to create customized modular plant systems at scale. This approach significantly reduces the time and costs associated with bringing synthetic biology products to market, addressing inefficiencies in traditional biomanufacturing processes.

Kismet Technologies develops cerium oxide-based antimicrobial materials enhanced with chitosan and silver to provide long-lasting pathogen protection on surfaces. This technology reduces the frequency of illness by maintaining pathogen-free environments, thereby minimizing the need for frequent disinfection in various industries.