Top 50 Chemical Manufacturing - Pre Seed

Atomgrid operates a technology-enabled platform for custom manufacturing and sourcing of specialty chemicals, managing the entire process from R&D to bulk production and delivery. By leveraging a team of chemical engineers and advanced manufacturing techniques, Atomgrid addresses the challenges of quality, affordability, and speed in sourcing hard-to-find raw materials and niche chemical products.

This company utilizes synthetic biology and cyanobacteria to convert captured CO2 into high-value chemical molecules. Their platform re-engineers natural metabolic pathways using AI-driven modelling to produce sustainable ingredients for various industries. This approach offers a regenerative alternative to traditional chemical manufacturing without sacrificing product efficacy.

Mattiq develops modular electrochemical systems that utilize renewable inputs to produce clean chemicals, addressing the fossil fuel dependency of the trillion-dollar chemicals sector. By creating iridium oxide alternatives, the company enhances supply chains for clean hydrogen production and enables the decarbonization of a wide range of chemicals and fuels at industrial scale.

Turnover Labs utilizes an ultra-durable electrolysis system to convert dilute CO2 emissions into high-value chemical products. This waste-to-value technology enables on-site, modular production, avoiding complex global supply chains. The system offers chemical manufacturers a pathway to low-carbon feedstocks at competitive prices while mitigating carbon taxes.

Ligo Biosciences builds deep‑learning generative models that design novel enzymes for the chemical industry. By training on natural protein sequences and structures, their platform creates catalysts that can accelerate and scale the synthesis of materials and products, reducing reliance on traditional chemical processes. The company monetizes access to its enzyme‑design platform through licensing and service agreements with industrial partners seeking more efficient biocatalytic solutions.

InRoad is a digital software system designed for the chemical industry, providing solutions that enhance operational efficiency and regulatory compliance. The platform streamlines data management and process optimization, addressing challenges related to safety and environmental standards in chemical production.

Nature's Principles utilizes a patented fermentation platform to convert diverse residual feedstocks into bio-based lactic acid, a versatile chemical used in bioplastics and food preservation. The company addresses the challenge of waste management by transforming side streams into valuable products, promoting a circular economy in chemical production.

ReactWise provides a machine learning-based software platform for optimizing chemical reactions by rapidly identifying ideal process parameters without requiring coding expertise. This solution accelerates process development by up to 30 times, enabling researchers to efficiently analyze and optimize reactions while conserving time and resources in the laboratory.

MacroCycle uses a patented chemical process to upcycle end‑of‑life plastics and polyester waste into virgin‑grade PET and polyester resins. The technology synthesizes macrocycles, achieving up to 80 % lower energy use than traditional recycling and enabling zero‑carbon production when powered by renewables, while delivering drop‑in material that meets PCR regulations without a green premium.

Spark produces decarbonized hydrogen and solid carbon through a novel hydrogen methane plasmalysis method that significantly reduces electricity consumption. This technology provides a cleaner alternative to natural gas for industrial heat and eliminates CO2 emissions associated with traditional solid carbon manufacturing.

Homeostasis develops processes to manufacture critical materials using captured carbon dioxide as a primary feedstock. This approach focuses on sustainable material production by leveraging atmospheric carbon. The company provides an alternative supply chain for essential industrial inputs derived from CO2.

Procense offers an end‑to‑end manufacturing platform that delivers live production data, intelligent automation, and continuous process optimization, bridging gaps left by legacy ERP and MES systems. The solution includes plug‑and‑play 5G/4G IoT devices, digital production and quality forms, and built‑in audit‑ready compliance with 21 CFR Part 11 and GMP standards, enabling regulated manufacturers to reduce cycle times and eliminate manual data entry errors.

PhaBuilder uses synthetic biotechnology to engineer halophilic microorganisms for the production of high-value, biodegradable materials. Their focus is on producing PHA, a biodegradable plastic alternative, as well as other specialty chemicals like ectoine and cadaverine, using next-generation industrial biotechnology.

Intellegens utilizes machine learning to optimize the design of experiments in materials and chemicals, significantly reducing the number of required experiments by up to 90%. This technology effectively handles sparse and noisy data, enabling faster and more cost-efficient R&D processes across various industries, including manufacturing and pharmaceuticals.

Fermelanta develops innovative microbial production processes for plant-based chemicals using synthetic biology. The company engineers cell factories to sustainably and scalably produce valuable molecules derived from nature. These plant secondary metabolites serve as raw materials for pharmaceuticals, cosmetics, and health foods.

DyeRecycle provides chemical circularity solutions for the textile industry by recovering dyes from textile waste. Their technology enables the reuse of dyestuff to color new garments while facilitating efficient fiber recycling through decolouration. This process utilizes sustainable green chemistry to address dye pollution and textile waste challenges.

Exposome develops chemisorptive, customizable molecular filters for air and water treatment, effectively recycling industrial pollutants into usable raw materials. The company addresses pollution and compliance challenges in sectors such as chemical manufacturing, pharmaceuticals, and textiles, significantly reducing harmful emissions and effluents.

Anferra uses a proprietary hydrometallurgical process to convert hazardous steel grinding sludge into high‑purity iron chloride for water‑treatment and hydrogen gas as a clean‑energy by‑product. This enables steel processors to cut disposal costs and eliminates landfill waste, while chemical manufacturers can replace virgin iron with recycled iron chloride, supporting circular economy and reducing carbon emissions.

The startup develops bio-renewable and biodegradable emulsions for adhesives, binders, and coatings, utilizing plant-based materials to replace petroleum-derived components. This transition significantly reduces environmental pollution and promotes sustainability in industrial applications.

Green Factory AI provides an AI-powered process optimization platform specifically for heavy industries like pulp & paper, chemicals, and iron & steel. The software automates process control to reduce energy, chemical, and resource consumption across manufacturing phases. This optimization directly increases profitability while supporting sustainability goals through lower operational inputs and emissions.

This startup uses cyanobacteria and industrial waste to capture carbon dioxide and produce carbon-negative minerals. These minerals can then be used in manufacturing, reducing reliance on traditional mining and lowering the carbon footprint of end products.

Aternium produces industrial‑grade hydrogen and heavy water using high‑efficiency electrolysis powered by renewable electricity. Its modular plants integrate real‑time digital controls and safety systems to deliver low‑carbon hydrogen directly to large‑scale industrial customers in the Mid‑Atlantic, reducing emissions and production costs.

RiKarbon develops renewable oils and ingredients using non-conventional carbon feedstocks, including agricultural waste, to create bio-based products for the specialty and performance chemicals market. This approach addresses the need for sustainable alternatives in industries facing stringent environmental regulations, such as lubricants and personal care products.

This company provides data-driven solutions to accelerate chemical process development and optimization. They generate FAIR, machine-actionable reaction data and utilize computational models to deliver rapid solvent screening and intrinsic kinetic modeling. Their services enable clients to de-risk scale-up by accurately predicting process performance before committing to production.

LYGG develops novel anti-aging ingredients for the cosmetic and personal care industries. The company focuses on synthesizing and producing advanced chemical compounds designed to target biological markers of aging. This specialized ingredient portfolio supports formulators in creating next-generation anti-aging skincare products.

TMTP Labs produces chemically pristine graphene using a scalable process that requires only water, graphite, and electricity, making it environmentally friendly and cost-effective. This technology enhances the performance of materials across various industries, including construction, plastics, and energy, by significantly improving strength, conductivity, and recyclability.

The startup develops a fermentation-based technology platform that produces sustainable oils for various applications, including food ingredients and aviation fuel, while mitigating deforestation. By utilizing this scalable production method, the company enables businesses to implement environmentally responsible practices and reduce reliance on traditional oil sources.

PlasNifix develops a plasma‑assisted nitrogen fixation technology that produces ammonia at lower temperatures and pressures than the conventional Haber‑Bosch process. The patented method uses gaseous catalysts and can be powered entirely by renewable electricity, reducing energy demand and CO₂ emissions. This enables greener ammonia for fertilizer and hydrogen transport applications.

The startup designs and manufactures soot blowers and boiler efficiency systems for the pulp and paper, power, petrochemical, and biomass industries. These systems remove residue and deposits from boiler walls and heat exchangers, preventing operational plugging and minimizing downtime for clients.

ChemCloud is a digital procurement marketplace that centralizes the sourcing, purchasing, and tracking of chemicals from verified suppliers, streamlining the workflow for both buyers and sellers. This platform addresses inefficiencies in chemical procurement by automating order management and providing real-time tracking, enabling businesses to make informed decisions and optimize their supply chains.

MetGen provides custom‑engineered enzyme solutions and industrial enzyme manufacturing to remove enzymatic bottlenecks in biorefineries, enabling the efficient conversion of lignocellulosic biomass into bio‑based chemicals and materials. Their services include protein engineering, process development, and a portfolio of renewable additives such as SHIELD, METNIN™ resin, nanopolyol, and lignin fractions, helping customers replace petroleum‑derived inputs with higher‑yield, lower‑cost sustainable alternatives.

Roam AI provides an AI‑driven platform that continuously analyzes well‑level data to optimize electric submersible pump (ESP) operation and chemical treatment cycles for upstream oil and gas operators. The solution offers semi‑autonomous and fully autonomous control modes, real‑time dashboards, and secure cloud‑native data pipelines that reduce equipment failures, extend pump life, and lower chemical costs.

Plastogaz utilizes catalytic hydrocracking technology to convert waste plastics into high-quality circular feedstock for the chemical industry, significantly enhancing energy efficiency and product yield. This process addresses the challenge of plastic waste by transforming it into valuable resources, thereby supporting sustainability and reducing carbon footprints in chemical production.

ESy-Labs specializes in organic electrosynthesis and electrochemical recycling, utilizing statistical and software-driven methods to optimize chemical processes. The company addresses the need for sustainable chemical production and recycling by enabling efficient synthesis and recovery of organic and inorganic materials, reducing reliance on hazardous chemicals and critical raw materials.

SilicoLife uses AI‑guided precision fermentation to engineer microbes that produce high‑purity food, nutrition, and supplement ingredients, reducing development time and production costs. The platform offers scalable, sustainable manufacturing and real‑time quality monitoring, enabling ingredient makers to secure reliable, eco‑friendly raw materials.

Carbon Waters develops a unique, low-environmental-impact process for producing stable, pre-dispersed graphene additives that enhance the thermal and mechanical properties of conventional materials. Their technology addresses the need for improved energy efficiency and material longevity while providing alternatives to toxic substances in various industrial applications.

NTRDE™ provides end-to-end decision-making software for chemical companies, integrating proprietary knowledge assets to enhance market analysis and strategic planning. The platform reduces research time and improves corporate performance by streamlining workflows and facilitating cross-divisional collaboration.

Chemarc is a B2B digital platform that facilitates the buying and selling of chemicals, connecting vendors with streamlined transaction processes. The platform addresses inefficiencies in chemical procurement by providing a centralized marketplace that enhances visibility and reduces transaction costs for businesses.

The startup manufactures algae-based paints using natural algae as a raw material, providing a non-toxic alternative to traditional chemical paints. This product contributes to healthier indoor air quality and helps meet environmental regulations by reducing harmful emissions associated with conventional coatings.

Nano Catalytics develops RF-activated nano and micro particles that release catalysts to initiate polymerization on demand, allowing manufacturers to cure materials through opaque objects without heating the entire part. This technology significantly reduces production time by up to 10 times, lowers energy costs, and enables the use of heat-sensitive materials, enhancing design possibilities in manufacturing.

The startup develops renewable energy reactors that utilize frictive heating, cavitation, and acoustic pressure to decompose plastics and agricultural waste into renewable chemicals and fuels. This technology enables industries to convert waste materials into clean energy, contributing to sustainability and reducing environmental pollution.

Rivalia Chemical recovers valuable rare earth elements from industrial wastes using proprietary technology. Their process utilizes recyclable chemicals to streamline extraction and minimize downstream processing requirements. This approach supports the green technology supply chain while providing a sustainable waste management solution.

Indrio Technologies utilizes patented laser-based chemical detection technology to provide precise identification of chemical substances in various environments. This innovation addresses the limitations of traditional chemical sensors, enhancing accuracy and reliability in the $32 billion chemical sensor IoT market.

The startup develops biotechnological processes that utilize anaerobic and aerobic microbial production hosts for the efficient conversion of carbon dioxide into protein for aquaculture and biopolymer building blocks. This approach provides a sustainable method for producing value-added chemicals, addressing the need for economical solutions in various industries facing carbon emissions challenges.

HazEL provides a centralized, searchable repository for chemical data to simplify chemical risk management decisions across various sectors. The platform uses reliable data and a proprietary HEAT model to help users identify hazardous chemicals and chemicals of emerging concern. This enables agricultural, regulatory, and insurance stakeholders to make safer, more sustainable choices and ease compliance burdens.

The startup develops urease inhibitors derived from watercress and PEITC for applications in continence care, cosmetics, and food products. Their natural formulations help reduce ammonia production, improving product efficacy and safety for health-conscious consumers.

AC Biode develops chemical technologies focused on sustainability across several product lines. The company offers chemical catalysts for low-temperature plastic depolymerization and catalytic pyrolysis to convert plastic waste into oil feedstock. Additionally, AC Biode provides CO2 capture technology that converts captured carbon into glass, alongside AC battery systems and fluorine-free repellent materials.

The startup develops bio-produced textile dyes using customized microbial strains and secondary genomes tailored for various industrial applications, including fuels, chemicals, and materials. This technology addresses the need for sustainable and efficient alternatives to traditional synthetic dyes, reducing environmental impact in manufacturing processes.

Sages manufactures biodegradable dyes using a proprietary biochemical process that extracts phytochemicals from non-edible food waste. This approach addresses the environmental impact of synthetic dyes, which contribute to 20% of global wastewater and contain toxic, non-biodegradable chemicals.

MECHANOCROSS implements mechanochemical technology for advanced organic synthesis, offering clean and efficient chemical solutions for industry. The company develops and provides novel functional materials exclusively achievable through this specialized synthesis method. They also facilitate joint research projects to disseminate mechanochemical knowledge and foster industrial collaboration.