VIVAN Therapeutics utilizes the Personal Discovery Process to replicate a patient's genetic profile and screen up to 500,000 drug combinations using engineered fruit fly avatars. This approach addresses the challenge of drug resistance in cancer treatment by identifying effective multi-drug therapies tailored to the unique mutations of each patient's tumor network.
Funding
$3.7M raised to dateRaised to date based on public sources. This may differ from the amount the company actually raised and is based only on what is publicly available on the internet.
Founders
Product
Problem
Cancer treatment is often hindered by drug resistance due to the unique mutations within each patient's tumor network. Traditional methods of modeling tumors, such as using mice, cannot create a sufficient number of avatars to test the multitude of drug combinations needed to overcome this resistance. This complexity makes it difficult for oncologists to determine the most effective treatment plan for individual patients.
Solution
Vivan Therapeutics offers a personalized approach to cancer treatment by replicating a patient's genetic profile in fruit fly avatars and screening thousands of drug combinations. The Personal Discovery Process (PDP) engineers the genetic complexity of a patient's tumor network into up to 500,000 fruit fly avatars. Using robotics, the company evaluates up to 2,000 FDA/NICE approved drugs, including non-cancer drugs, to identify efficacious drug combinations for the individual's avatar population. This method allows for the testing of a vast array of drug combinations to identify those that can effectively address resistant tumors, offering treatment recommendations tailored to the patient's unique tumor network.
Target Audience
Vivan Therapeutics primarily serves individuals with colorectal, gastrointestinal, head, and neck cancers, as well as those with rare cancers for which there is no established treatment.
Features
- Exome sequencing to capture the patient's tumor network
- Engineering of patient-specific mutations into fruit fly avatars
- Screening of up to 2,000 FDA/NICE approved drugs on fruit fly avatars
- Use of robotics to automate drug testing and data collection
- Identification of effective drug combinations, including non-cancer drugs
- Treatment recommendations report based on the most efficacious combinations
- Integration of artificial intelligence to reduce costs and accelerate treatment recommendations