This company provides fast, label-free nanoparticle characterization for particles ranging from 20 to 300 nm. Their technology enables precise measurement of empty-full capsid ratios, concentration, and aggregation control. The system requires low sample volumes and is designed for GMP compliance in bioprocessing applications.
Funding
Funding not disclosed
Founders
Product
Problem
The development and manufacturing of biomedicines, such as gene therapies and mRNA vaccines, require precise characterization of complex biological samples, but existing optical instruments often lack the sensitivity to accurately detect and measure individual nanoparticles, especially those smaller than 60 nm. This limitation hinders the ability to control critical parameters like vector loading, concentration, and aggregation during production.
Solution
UNVEIL provides advanced optical instrumentation based on interferometric microscopy for characterizing and analyzing complex biological samples at the single-particle level. Their LIGHTWEIGH instrument utilizes a proprietary image processing software to provide quantitative measurements of concentration, mass, and size for nanoparticles in the 20-300 nm range. The technology overcomes sensitivity limitations of traditional optical instruments by increasing the signal by four orders of magnitude, enabling the detection of individual viruses, extracellular vesicles, and lipid nanoparticles without labeling. This allows for real-time monitoring and optimization of nanoparticle production, including vector loading control, concentration optimization, and aggregation monitoring.
Target Audience
The primary target audience includes researchers and manufacturers in the biomedicine industry involved in the development and production of gene therapies, mRNA vaccines, and other advanced therapeutics.
Features
- Interferometric microscope combined with proprietary image processing software
- Enables detection and characterization of nanoparticles in the 20-300 nm range
- Measures concentration, mass, and size at the single-particle level
- Requires only 5µL of sample and provides results in 5 minutes
- Label-free technology that does not alter the sample
- GMP compliant
- Provides 3D holographic imaging to record images from a small volume within the sample
- Software tracks particles and reconstructs their trajectory to derive hydrodynamic diameter