Unomr provides a tabletop platform that uses nanopore technology for single-molecule protein analysis, delivering high‑resolution proteomics and modification detection. The system enables precise characterization of proteins for drug discovery, biologics development, and cell line optimization. It also supports research into protein functionality for medical food and other high‑impact applications.
Funding
Funding not disclosed
Founders
Product
Problem
Current mass spectrometry techniques lack the sensitivity to accurately quantify low-abundance proteins and site-specific post-translational modifications, hindering the understanding of drug-protein interactions and slowing down pharmaceutical R&D. Existing nanopore systems have limitations in dynamic pore size adjustment and error rates when analyzing single molecules.
Solution
UNOMR is developing a serial interface nanopore (iNP) technology that enables in-depth single-molecule proteomics analysis with significantly improved sensitivity. Their dynamic nanopore sensor allows for on-demand adjustment of pore size, tailored to measure single amino acids or large glycans. The integration of target-specific binders enables the measurement of low-abundance proteins without full sequencing. By integrating several pores in series, UNOMR's technology measures a single molecule multiple times, reducing error rates and extracting more information than current nanopore systems. This technology facilitates the quantification of whole proteins, detection of low-abundance molecules, analysis of post-translational modifications, and even protein sequencing.
Target Audience
UNOMR's primary customers include academic researchers, biotechnology companies, and pharmaceutical R&D teams seeking to improve and accelerate drug development and protein quality control.
Features
- Dynamic nanopore sensor with on-demand adjustable pore size in the sub-nanometer range
- Target-specific binders (e.g., aptamers) for measuring low-abundance proteins
- Serial nanopore integration for multiple measurements of a single molecule
- Chemically functionalized nanopores for controlled translocation speeds
- Ability to measure site-specific glycosylation or phosphorylation
- Potential for site-specific detection of all amino acids for whole protein sequencing
- AI-based data analysis for next-generation single-molecule proteomics