Uniform Bio's MOSgen platform produces uniform, permeable cell-matrix microdroplets at industrial scale for high-throughput 3D biology. The benchtop system generates 70,000 droplets per lane in under 15 minutes with less than 3% diameter variation, enabling patient-derived tumor-immune co-culture assays. Its image-driven PID control and drop-in workflow let labs run 3D assays using existing reagents, labware, and instruments.
Funding
Funding not disclosed
Founders
Product
Problem
Scaling 3D biology for high-throughput applications remains a major bottleneck. Traditional 3D culture methods are labor-intensive, produce inconsistent replicates, and require specialized instrumentation, limiting their use in drug discovery and translational research with primary patient samples.
Solution
Uniform Bio's MOSgen is a benchtop platform that generates uniform, permeable cell-matrix microdroplets at industrial scale, bringing 3D biology into a standard 2D workflow. Each MOS (micro-organic spheroid) is a ~240 µm, 7 nL droplet containing cells within a matrix, permeable to stains, antibodies, and immune cells. Image-driven PID control maintains diameter uniformity below 3% CV from the first to the 70,000th droplet. The platform supports live killing assays, co-cultures with endogenous or exogenous T-cells, and compatibility with standard assay readouts like live imaging, flow cytometry, and viability testing.
Target Audience
Primary customers are high-throughput screening cores, pharma R&D groups, and translational research programs conducting immuno-oncology drug development with primary patient-derived samples.
Features
- Produces 70,000 MOS per lane with four parallel lanes per run, completing a full run in under 15 minutes with zero downtime between runs
- Image-driven PID size control delivers less than 3% CV diameter uniformity across all droplets
- Confirmed matrix compatibility with PEG, Matrigel, and Collagen, supporting cell densities from 1 to 400 cells per MOS
- Compatible with patient samples, iPSCs, organoids, spheroids, clonal lines, primary tissue, and PDXO models
- Enables single-MOS resolution live imaging of immune cell killing events and whole-well biology across drug modalities
- Works with existing reagents, labware, and instruments without requiring new detection hardware