Unchained Labs offers plate‑based instruments that combine dynamic light scattering, UV/Vis, fluorescence, and viscometry to enable low‑volume, high‑throughput characterization of proteins, viral vectors, and nanoparticles. Integrated automation and AI‑driven workflow management accelerate screening, formulation, and quality control for biologics and gene‑therapy development.
Funding
$155M raised to dateRaised to date based on public sources. This may differ from the amount the company actually raised and is based only on what is publicly available on the internet.
Founders
Product
Problem
Researchers developing biologics, gene and cell therapies, and nanoparticle-based modalities often face bottlenecks in sample preparation, biophysical characterization, and process optimization because existing instruments are low‑throughput, require large volumes, and lack integration with automation.
Solution
Unchained Labs provides a portfolio of plate‑based instruments that combine dynamic light scattering, UV/Vis spectroscopy, fluorescence, and viscometry in a single, low‑volume format. The suite includes dedicated platforms for protein stability (DSF), particle sizing and aggregation (DLS/UV‑Vis), viscosity measurement, nucleic‑acid quantification, and high‑throughput nanoparticle formulation. Complementary benchtop systems automate ultrafiltration/diafiltration buffer exchange and microfluidic mixing for nanoparticle synthesis, while the Stuntman AI engine orchestrates end‑to‑end workflows, data capture, and analysis. By delivering high‑throughput, plate‑compatible measurements and integrated automation, the tools accelerate early‑stage screening, formulation development, and quality control for advanced therapeutics.
Target Audience
Primary customers are R&D and process development teams in biopharma companies developing monoclonal antibodies, recombinant proteins, AAV and lentiviral vectors, lipid nanoparticles, exosome therapeutics, and related genomic products.
Features
- Plate‑based DLS/UV‑Vis/fluorescence instruments (Stunner, Aunty, Leprechaun) enabling low‑volume, high‑throughput particle sizing, aggregation, and titer assessment for proteins, AAV, lentivirus, and LNPs
- High‑throughput DSF platform for protein and capsid stability screening across 96‑well plates
- Low‑volume UV‑Vis quantification (Lunatic) for DNA, RNA, and protein concentration with rapid readout
- Flow‑resistance viscometer (Honeybun) delivering precise viscosity measurements for biologics and formulations
- Fully automated benchtop UF/DF systems (Unagi, Big Tuna) for buffer exchange, concentration, and organic removal in a plate format
- Microfluidic mixing platforms (Sunscreen, Sunshine, Sunbather) for rapid nanoparticle formulation screening, scale‑up, and GMP‑ready production
- AI‑driven Stuntman automation layer that configures instruments, schedules runs, and aggregates data into searchable reports