Tune Therapeutics utilizes its TEMPO platform to precisely modulate gene expression without altering DNA, enabling the treatment of complex diseases by restoring healthy cellular function. This technology addresses the limitations of traditional genetic medicine, expanding its applicability from rare genetic disorders to a wide range of chronic and age-related conditions.
Funding
$222.4M raised to dateRaised to date based on public sources. This may differ from the amount the company actually raised and is based only on what is publicly available on the internet.
RVYFounders
Product
Problem
Many common diseases are not caused by defective genes, but by genes being expressed incorrectly, leading to cellular dysfunction and disease. Current genetic medicine approaches are limited in their ability to address these complex, multi-genic conditions without permanently altering the DNA sequence.
Solution
Tune Therapeutics is developing a new class of genetic medicines based on its TEMPO platform, which precisely modulates gene expression without altering the underlying DNA. This "genetic tuning" approach enables the activation, silencing, or fine-tuning of specific genes to restore healthy cellular function. By targeting the epigenetic switches that control gene expression, TEMPO expands the scope of genetic medicine beyond rare, single-gene disorders to address common, chronic, and age-related diseases. The platform's multiplex capacity allows for the simultaneous tuning of multiple genes, offering a more nuanced and reversible approach compared to traditional gene editing.
Target Audience
The primary target audience includes individuals with severe diseases, such as those with high cholesterol or chronic viral infections like Hepatitis B, as well as those with chronic, age-related autoimmune conditions.
Features
- TEMPO platform enables precise, multiplexed control over gene expression
- Modulation of gene activity without cutting or altering the DNA sequence
- Ability to dial gene expression up or down to restore cellular function
- Potential to target master controllers of cellular identity and function
- Applications in steering stem cells, mediating tissue repair, and reducing chronic inflammation
- Tunable duration of effect, allowing for transient or sustained gene modulation