Tribune Therapeutics is developing novel medicines that target key CCN protein family members to inhibit the pro-fibrotic signaling pathways responsible for fibrosis across various tissues. Their lead candidate, TRX-44, effectively blocks fibrotic signaling in preclinical models of lung and kidney fibrosis, addressing the critical issue of organ scarring and dysfunction.
Funding
Funding not disclosed
Founders
Product
Problem
Fibrosis, characterized by the replacement of healthy tissue with scar tissue, leads to organ dysfunction and failure across various tissues, regardless of the initial cause, such as injury, toxins, or immune dysfunction. Current treatments often fail to address the underlying mechanisms driving fibrosis, resulting in limited efficacy in preventing disease progression.
Solution
Tribune Therapeutics is developing novel medicines targeting key CCN protein family members, which are central to the pro-fibrotic signaling pathways responsible for fibrosis. Their lead candidate, TRX-44, interferes with activated pro-fibrotic CCN domains to block fibrotic signaling. This approach aims to interrupt the cycle of scar formation by co-opting natural mechanisms and efficiently targeting multiple drivers of fibrosis. By leveraging new insights into the structure-function relationships of CCN proteins, Tribune Therapeutics aims to produce strong anti-fibrotic effects and prevent the progression of fibrotic diseases.
Target Audience
The primary target audience includes patients suffering from fibrotic diseases affecting organs such as the heart, kidneys, lungs, or liver, as well as the healthcare providers who treat them.
Features
- TRX-44, a lead candidate that blocks fibrotic signaling by interfering with activated pro-fibrotic CCN domains.
- Targets multiple drivers of fibrosis to stop the cycle of scar formation.
- Designed to address the underlying mechanisms of fibrosis, regardless of the cause, tissue, or diagnosis.
- Aims to prevent the replacement of healthy, functional tissue with collagen and other connective material.