Toxys provides mechanism-based in vitro assays, such as ToxTracker and ReproTracker, to assess genotoxicity and developmental toxicity of chemical compounds, enabling early identification of potential carcinogenic properties. Their services help pharmaceutical and chemical companies make informed decisions during product development, reducing reliance on animal testing and enhancing regulatory compliance.
Funding
Funding not disclosed
Founders
Product
Problem
Traditional methods for assessing the toxicity of chemical compounds rely heavily on animal testing, which is time-consuming, expensive, and raises ethical concerns. Existing in vitro assays often lack the mechanistic detail needed to accurately predict human toxicity and carcinogenic potential.
Solution
Toxys provides a suite of innovative, mechanism-based in vitro assays, including ToxTracker, ReproTracker, and ToxProfiler, designed to evaluate the genotoxicity, developmental toxicity, and overall toxicity of chemical compounds. These assays utilize human-derived cells and advanced reporter technologies to provide detailed insights into the mode-of-action of toxic substances. By offering mechanistic understanding of toxicity, Toxys enables pharmaceutical, chemical, and cosmetics companies to make informed decisions during product development, reduce reliance on animal testing, and enhance regulatory compliance. Toxys' assays can be used for early screening, validation of conflicting results, and adverse outcome pathway (AOP) approaches.
Target Audience
Toxys' primary customers are pharmaceutical companies, chemical companies, cosmetics companies, and other organizations involved in product development and safety testing.
Features
- **ToxTracker Suite:** A collection of in vitro genotoxicity assays that identify genotoxic compounds and provide insight into their mechanism of action, differentiating between DNA damage, oxidative stress, and protein damage. Includes ToxTracker ACE, TubulinTracker, ToxTracker AO, and ToxTracker EMP.
- **MutaTracker:** An all-in-one mammalian cell-based assay that combines mutation detection using SMM-seq with genotoxicity prediction using ToxTracker to detect gene mutations and structural DNA variants.
- **ReproTracker:** A human induced pluripotent stem cell (hiPSC)-based assay that assesses key events during early embryonic development to identify teratogens.
- **ToxProfiler:** A human cell-based reporter assay that identifies toxicologically significant pathway activation via high content imaging in 384-well plates, constructing a unique ToxProfiler fingerprint to identify in vivo relevant toxicities such as drug-induced liver injury (DILI).
- **DNA Repair-Profiler:** Assay to assess the DNA repair mechanism.
- **Automated Micronucleus screening:** Assay for automated screening of micronuclei.
- **In vitro comet assay:** Assay to detect DNA damage.
- **Hprt mutation assays:** Mutation assays for detecting gene mutations.
- **Clonogenic survival assay:** Assay to measure the ability of cells to form colonies after exposure to a toxic substance.
- **Alamar Blue assay:** Assay to measure cytotoxicity.