This company develops micro- and nano-fabricated electrode leads for high-precision deep brain stimulation (DBS) that offer single-neuron resolution targeting. They integrate these leads with a control chip and a machine learning platform for closed-loop sensing and automated parameter adjustment based on neural activity. This technology aims to reduce off-target side effects and eliminate the need for frequent, manual DBS reprogramming.
Funding
Funding not disclosed
Founders
Product
Problem
Existing deep brain stimulation (DBS) therapies utilize large electrodes that lack spatial precision, leading to off-target stimulation and associated side effects. Continuous, open-loop stimulation protocols can also result in decreased responsiveness over time, necessitating frequent clinical reprogramming and increasing the burden on patients.
Solution
Torpedo Therapeutics is developing high-precision, closed-loop DBS devices that leverage micro- and nano-fabrication technologies to create ultra-small electrodes. These micro-electrodes enable stimulation with single-neuron precision, minimizing off-target effects and potential side effects. The system incorporates real-time neural activity sensing and a machine learning-driven data analysis platform to automatically adjust stimulation parameters, reducing the need for frequent reprogramming and optimizing long-term efficacy. This closed-loop approach aims to provide more personalized and adaptive therapy for neurological disorders.
Target Audience
The primary target audience includes patients with Parkinson’s disease, Essential Tremor, Dystonia, and drug-resistant Epilepsy, as well as clinicians specializing in deep brain stimulation therapies.
Features
- Micro-electrode leads with individual electrodes 150 times smaller than existing DBS electrodes
- High spatial resolution stimulation capable of single-neuron precision
- Closed-loop sensing and stimulation platform for real-time neural activity monitoring
- Machine learning-driven data analysis platform for predictive assessments
- Automated adjustment of stimulation parameters based on local neural activity
- Electronic chip for signal readout and stimulation control, designed to replace bulky implantable pulse generators