TISSIUM
TISSIUM develops biomorphic programmable polymers for tissue reconstruction, offering light-activated materials that conform to and integrate with surrounding tissue. The company's platform supports applications across peripheral nerve, cardiovascular, and gastrointestinal procedures, including its FDA-authorized COAPTIUM® CONNECT system for sutureless nerve coaptation.
- New Materials
- Medical Devices
- Healthcare Technology
- Biotechnology
- Chemical Technology
- Hardware
Funding
Raised to date
€168.8MRaised to date based on public sources. This may differ from the amount the company actually raised and is based only on what is publicly available on the internet.
Est. $183.9Macross 4 rounds
BPCM+10€30M · Series D
Announced Dec 2025 · from article date
Disclosed cumulative: $141.7M
Not on chart (date unknown): Series B €38.8M
Founders
Founder details are not available yet.
Product
Problem
Surgeons often lack materials that can both conform to complex tissue geometries and provide a secure, biocompatible bond without extensive suturing, limiting the effectiveness of reconstructive procedures across various specialties.
Solution
TISSIUM’s biomorphic programmable polymers are a family of light‑activated, elastomeric materials that can be applied as a viscous pre‑polymer and cured in seconds with visible blue light. The polymers conform to surrounding tissue and integrate with it, creating a strong, flexible bond that supports tissue reconstruction. By adjusting the polymer’s building blocks, the material can be tuned to match the mechanical and degradation requirements of specific tissues, enabling use in open and minimally invasive surgeries. The platform also supports 3D‑printed implants, drug‑eluting depots, and a sutureless nerve coaptation system (COAPTIUM® CONNECT), the first FDA-authorized solution for atraumatic peripheral nerve repair. This suite of technologies provides surgeons with versatile, off‑the‑shelf solutions for sealing, fixing, and rebuilding tissue across cardiovascular, peripheral nerve, and gastrointestinal applications.
Target Audience
Primary customers are surgeons and interventional specialists in cardiovascular, peripheral nerve, and gastrointestinal fields who require reliable tissue sealing, fixation, or reconstruction solutions, as well as medical device manufacturers seeking customizable polymer platforms for implant development.
Features
- Light‑activated curing (visible blue light) that solidifies the polymer within seconds, minimizing operative time
- Biomorphic behavior: the cured elastomer conforms to and integrates with native tissue for seamless reconstruction
- Programmable polymer chemistry allowing customization of mechanical strength, elasticity, and degradation rates to suit specific tissue types
- Formulation options include viscous pre‑polymer for intra‑operative application, high‑resolution 3D‑printed implants, and drug‑loaded depots for localized therapy
- COAPTIUM® CONNECT provides a sutureless, atraumatic nerve coaptation system approved by the FDA for peripheral nerve repair
- Compatible with both open surgical techniques and minimally invasive procedures, including catheter‑based delivery
- Manufactured as aseptic prefilled syringes and sterile 3D‑printed devices to ensure ready‑to‑use clinical deployment