Synoligo offers custom oligonucleotide synthesis for researchers and developers, specializing in complex modifications and high-purity DNA and RNA sequences. They provide tailored oligo solutions for molecular diagnostics, therapeutic development, and advanced research applications, enabling faster discovery and development pipelines.
Funding
Funding not disclosed
Founders
Product
Problem
Researchers and developers often face limitations in obtaining custom oligonucleotides with complex modifications and specific purity requirements, leading to project delays and increased R&D costs. Standard synthesis services may not accommodate niche applications or challenging chemical constructs, hindering scientific advancement in areas like molecular diagnostics and therapeutic development.
Solution
Synoligo provides custom oligonucleotide synthesis services, specializing in complex modifications and high-purity oligo production to meet diverse scientific needs. Leveraging state-of-the-art automation and proprietary processes, the company delivers tailored DNA and RNA sequences for research, molecular diagnostics, and therapeutic development. Synoligo's expertise in handling challenging synthesis projects and its commitment to rapid turnaround times enable clients to accelerate their discovery and development pipelines. The company also offers specialized probes for advanced applications such as MERFISH in spatial transcriptomics.
Target Audience
The primary customers are academic researchers, biotechnology companies, pharmaceutical firms, and diagnostic developers requiring custom oligonucleotide synthesis for experimental, diagnostic, or therapeutic applications.
Features
- Custom DNA and RNA oligonucleotide synthesis with lengths up to 250 bases via chemical synthesis, extendable with enzymatic methods.
- Expertise in incorporating over 500 unique modifications, including branched/dendrimer, circular DNA/RNA, and lipid modifications.
- Production of ultra-long oligos (150-250nt) and DNA-encoded libraries (DEL).
- Synthesis of specialized probes for molecular diagnostics, including PCR/qPCR primers, FISH/MERFISH probes, FRET probes, NGS adapters, and molecular beacons.
- Manufacturing of therapeutic development oligonucleotides such as antisense, immunostimulatory, mi-/sa-/siRNA, aptamers, and CRISPR gRNA.
- Capability to deliver low endotoxin levels (<0.005 EU/mg) for lipid-conjugated oligos and proprietary endotoxin removal processes.
- Fast turnaround times, with standard delivery within 15 business days and expedited options from 2-10 business days.
- Scalable production from nmol (μg) to mmol (100+ gram) quantities.
- Comprehensive quality control and characterization of final products.