Synfera
Synfera develops production platforms for complex heme proteins, combining protein engineering and precision fermentation to create functional products for biotechnology and research partners. Its flagship product, Aerus, is an engineered erythrocruorin-based oxygen carrier for cell culture, tissue engineering, preservation, and bioreactor research, offering a 25%+ lower price than current market alternatives at a working concentration of 25 mg/L.
- Biotechnology
Funding
Founders
Founder details are not available yet.
Product
Problem
Producing functional heme proteins is technically demanding because it requires supporting precise protein folding, assembly, and the incorporation of an iron-containing heme cofactor. Additionally, the right production and preparation approach depends on the target protein, its intended application, and the development stage, making a one-size-fits-all solution ineffective.
Solution
Synfera develops production approaches for complex heme proteins, combining protein engineering and precision fermentation to create useful material for internal products and partner programmes. Their flagship product, Aerus, is an engineered erythrocruorin-based oxygen carrier that addresses the limitations of traditional cell culture by providing even oxygen diffusion, protection against reactive oxygen species, and improved iron bioavailability. This results in increased cell proliferation and recombinant production, with a shelf life of 2-5 years. Synfera's platform is designed to be adaptable, starting with the specific protein and application needs of each partner rather than offering a standard catalogue.
Target Audience
Primary customers are biotechnology teams, researchers, and strategic partners in cell culture, tissue engineering, tissue preservation, and bioreactor applications who need functional heme proteins for their work.
Features
- Engineered erythrocruorin-based oxygen carrier with naturally gradual, on-demand oxygen release to prevent steep gradients and over-oxygenation
- Provides free radical scavenging to reduce oxidative stress and protect against reactive oxygen species
- Improves cellular iron bioavailability, boosting metabolism, productivity, and proliferation
- Lyophilised vial format with a 2-5 year shelf life under proper storage conditions
- Priced more than 25% below current market alternatives at a working concentration of ~25 mg/L
- Production platform combines protein engineering and precision fermentation to support complex heme protein folding, assembly, and cofactor incorporation