Syncell develops the Microscoop® platform, which utilizes automated photo-biotinylation for high-precision microscopy-guided proteomic discovery at cellular and subcellular levels. This technology enables the unbiased identification of protein constituents in tissue samples, addressing the limitations of traditional proximity labeling and mass spectrometry methods in understanding disease-associated protein interactions.
Funding
$30M raised to dateRaised to date based on public sources. This may differ from the amount the company actually raised and is based only on what is publicly available on the internet.
Founders
Product
Problem
Current methods for proteomic discovery in tissue samples, such as proximity labeling and mass spectrometry, often lack the spatial precision needed to identify protein constituents at cellular and subcellular levels, especially within complex tissue microenvironments. This limitation hinders the comprehensive understanding of disease mechanisms and the identification of potential therapeutic targets.
Solution
Syncell's Microscoop® platform enables high-precision, microscopy-guided proteomic discovery by combining automated photo-biotinylation with mass spectrometry. The platform allows researchers to identify protein constituents within specific subcellular regions of interest in FFPE, fresh frozen tissue, or fixed cell culture samples. By using a focused two-photon laser to activate a photoactivatable biotin-based probe, the Microscoop® platform achieves high spatial resolution (~350 nm) in protein labeling, bypassing the need for cloning and simplifying experimental workflows. This approach facilitates unbiased proteomic discovery, allowing for the identification of novel protein contents at disease-associated features and a deeper understanding of protein interactions and distributions within affected tissues. The Microscoop® platform integrates spatial discovery with spatial profiling, offering a comprehensive view of the protein landscape within selected cellular regions at subcellular precision.
Target Audience
The primary audience includes researchers in cell biology, cancer research, neurodegenerative disease research, and drug discovery who require high-precision proteomic analysis at the cellular and subcellular level.
Features
- Automated photo-biotinylation for precise protein labeling within user-defined regions of interest
- High spatial resolution (~350 nm) achieved through a focused two-photon laser
- Compatibility with FFPE, fresh frozen tissue samples, and fixed cell culture samples
- Unbiased proteomic discovery, enabling the identification of novel protein contents
- Streamlined workflow that bypasses the need for cloning
- Integration of spatial discovery and spatial profiling for comprehensive analysis
- Identification of protein interactions and distributions within affected tissues
- Reagent kits specifically designed and optimized to integrate with the Microscoop system