SPOC Biosciences provides an automated on‑chip platform that synthesizes up to 1,152 full‑length protein or peptide variants directly from DNA and measures their binding kinetics with high‑throughput surface plasmon resonance in a single run. The unified workflow eliminates separate expression and purification steps, delivering complete kinetic profiles (ka, kd, KD, residence time, Rmax) and developability metrics in weeks at roughly 10% of traditional costs, producing AI‑ready datasets for rapid drug‑design cycles.
Funding
Funding not disclosed
Founders
Product
Problem
Traditional protein production and kinetic analysis rely on separate, low‑throughput workflows that require recombinant expression, purification, and multiple instruments, making it slow, costly, and limiting the number of variants that can be evaluated.
Solution
SPOC Biosciences integrates on‑chip protein synthesis with high‑throughput surface plasmon resonance (HT‑SPR) to generate and test up to 1,152 full‑length protein or peptide variants on a single biosensor chip. The automated system translates DNA templates directly into captured, folded proteins in nano‑wells, then measures complete kinetic profiles (ka, kd, KD, residence time, Rmax) simultaneously. This unified workflow delivers rich, decision‑ready datasets—including affinity, specificity, epitope mapping, polyreactivity, and developability metrics—in weeks rather than months and at a fraction of the conventional cost. The resulting data are AI‑ready, enabling rapid model training, iterative design‑build‑test‑learn cycles, and more informed lead selection across antibody, mini‑protein, and small‑molecule programs.
Target Audience
Primary customers are biotech and pharmaceutical R&D teams developing antibodies, mini‑proteins, or other biologics, as well as AI‑driven drug design groups that require large, high‑quality kinetic datasets for model training.
Features
- Automated on‑chip synthesis of thousands of proteins directly from DNA, eliminating separate expression and purification steps
- High‑throughput SPR measurement of full kinetic parameters (ka, kd, KD, t½, Rmax) for up to 1,152 variants in a single run
- Integrated assays for expression titer, epitope binning, polyreactivity profiling, and stress‑stability screening on the same library
- AI‑compatible data output delivering tens of thousands of kinetic datapoints for model training and DBTL workflows
- Scalable platform supporting both SPR and MALDI‑TOF mass‑spectrometry for N × M interaction screening
- Cost‑effective per‑data‑point pricing (≈10 % of traditional recombinant SPR workflows) and rapid turnaround (days to weeks)