Singulomics offers end‑to‑end single‑cell and spatial multi‑omics services that combine proprietary protocols with 10x Genomics platforms and custom bioinformatics pipelines. Their AccuSomatic™ amplification reduces false‑positive somatic SNV calls by over 99 % while preserving sensitivity, and they provide high‑throughput RNA‑seq, ATAC‑seq, Multiome, Visium (including Visium HD) and Xenium spatial transcriptomics with turnkey data analysis and publication‑ready results for researchers in genomics, oncology, immunology, developmental biology, and drug discovery.
Funding
Funding not disclosed
Founders
Product
Problem
Researchers studying cellular heterogeneity and tissue architecture face limitations in accurately detecting somatic mutations, profiling gene expression, and mapping epigenomic features at single‑cell resolution due to high error rates in DNA amplification, bulky instrumentation, and loss of spatial context in conventional sequencing workflows.
Solution
Singulomics provides an end‑to‑end portfolio of single‑cell and spatial multi‑omics services that combine proprietary experimental protocols with 10x Genomics platforms and custom bioinformatics pipelines. Their AccuSomatic™ amplification eliminates over 99 % of false‑positive somatic SNV calls while preserving detection sensitivity, enabling reliable whole‑genome sequencing of individual cells. The company also offers high‑throughput single‑cell RNA‑seq, deep low‑input RNA‑seq, single‑cell ATAC‑seq, and Multiome (ATAC + gene expression) to capture transcriptomic and chromatin accessibility landscapes. For spatial profiling, Singulomics delivers Visium and Visium HD whole‑transcriptome mapping on fresh‑frozen or FFPE tissue, Visium IF multi‑omics, and Xenium in‑situ transcriptomics with subcellular resolution. All services include sample preparation, library construction, sequencing, and turnkey data analysis, producing publication‑ready results that link molecular profiles to cellular and tissue context.
Target Audience
Primary customers are academic and industry researchers in genomics, oncology, immunology, developmental biology, and drug discovery who require accurate single‑cell DNA mutation detection, transcriptomic or epigenomic profiling, and spatial mapping of tissue samples.
Features
- AccuSomatic™ whole‑genome amplification reduces false somatic SNV calls by >99 % without sacrificing sensitivity, compatible with WGS, WES, targeted and Sanger sequencing
- High‑throughput 10x Genomics single‑cell RNA‑seq and ultra‑low‑input deep RNA‑seq for fresh, frozen, or nuclei samples, with optional dead‑cell removal
- Single‑cell ATAC‑seq and Multiome (simultaneous ATAC + gene expression) using Chromium technology for thousands of nuclei per run
- Visium Spatial Gene Expression (fresh‑frozen and FFPE) with automated CytAssist transfer, delivering whole‑transcriptome maps at cellular resolution
- Visium HD Spatial Gene Expression provides continuous 2 µm × 2 µm barcoded squares for true single‑cell‑scale spatial profiling
- Xenium in‑situ transcriptomics offers high‑plex targeted panels (up to 5 K genes) with subcellular resolution on FFPE or fresh‑frozen tissue
- Integrated bioinformatics pipelines for variant calling, expression quantification, chromatin accessibility analysis, and spatial data integration, delivering ready‑to‑publish visualizations and reports