Simbryo offers a diagnostic platform that generates functional endometrial organoids from a patient’s stem cells to assess fertility. The suite includes assays for endometrial function, pathology, inflammation, microbiome composition, endometriosis biomarkers, and implantation window, delivering detailed reports for clinicians and actionable insights for patients. Revenue is generated through fee‑for‑service testing and licensing of its biobank and data resources to research institutions.
Funding
Funding not disclosed
Founders
Product
Problem
In vitro fertilization (IVF) success rates are inconsistent, and current diagnostic methods often fail to accurately assess endometrial receptivity, leading to repeated implantation failures and prolonged time to pregnancy for many patients. Traditional endometrial biopsies provide limited information about the complex interplay of factors influencing successful implantation.
Solution
Simbryo offers a comprehensive endometrial fertility testing platform that utilizes a 3D organoid model created from a patient's endometrial biopsy to evaluate the likelihood of successful blastocyst implantation. The platform provides personalized organoid-blastoid assays, endometrial microbiome analysis, and biomarker analysis to provide a detailed assessment of endometrial receptivity. By creating a microenvironment that mimics the patient's uterus, Simbryo aims to provide fertility clinics and researchers with more accurate and predictive information to improve patient outcomes and personalize treatment plans. The platform helps determine the likelihood of successful implantation and supports subsequent clinical decisions.
Target Audience
The primary target audience includes fertility clinics, reproductive endocrinologists (REIs), and clinical researchers focused on improving IVF success rates and understanding endometrial receptivity.
Features
- 3D organoid model of the patient's endometrium created from routine biopsy samples.
- Personalized organoid-blastoid assay to simulate and assess blastocyst implantation.
- Endometrial microbiome analysis to identify potential imbalances affecting receptivity.
- Biomarker analysis to quantify key factors influencing endometrial function.
- Cryopreservation of endometrial samples for future analysis and longitudinal studies.
- Collection kits provided to clinics for convenient sample acquisition.