The startup develops a single-cell sequencing technology that utilizes patented split-pool barcoding and combinatorial indexing methods to enhance sample indexing and cell throughput. This technology enables researchers to conduct a wide range of genomic, epigenomic, transcriptomic, and proteogenomic analyses efficiently.
Funding
$32.2M raised to dateRaised to date based on public sources. This may differ from the amount the company actually raised and is based only on what is publicly available on the internet.
TCFounders
Product
Problem
Current single-cell sequencing methods are limited by the number of cells or samples that can be processed, increasing costs and workflow complexity while reducing statistical power to detect true biological signals. Traditional single-cell RNA-seq workflows can be financially prohibitive and logistically challenging when applied to large-scale studies.
Solution
Scale Biosciences provides single-cell library preparation kits leveraging patented split-pool barcoding and combinatorial indexing methods to enhance sample indexing and cell throughput. The QuantumScale platform, powered by Quantum Barcoding technology, enables researchers to analyze more cells, integrate more samples, and explore more omics without increased cost or complexity. ScalePlex technology allows for the multiplexing of thousands of samples in a single run, streamlining workflows and reducing hands-on time. The company's solutions support various applications, from single-cell RNA sequencing and methylation to CRISPR screening, facilitating the discovery of complex biology at single-cell resolution.
Target Audience
The primary target audience includes researchers in cell biology, drug discovery, and genomics, as well as pharmaceutical companies and academic institutions seeking to scale their single-cell sequencing experiments.
Features
- Quantum Barcoding technology for massively parallelized barcoding, enabling analysis of millions of cells
- ScalePlex technology for multiplexing up to 9,216 samples, reducing workflow complexity and hands-on time
- Compatibility with various sample types, including cells, nuclei, and frozen tissue
- Streamlined workflow with fixation and pooling, preserving precious samples and saving time
- Cost-effective insights, maximizing experimental value with minimal hands-on time and efficient sample multiplexing
- Single Cell Methylation Kit for detecting single-cell DNA methylation states
- CRISPR Guide Enrichment Kit for amplifying CRISPR guide sequences alongside RNA sequencing libraries
- Data analysis pipeline (Scale Bio Seq Suite) for demultiplexing samples and generating cell-gene matrices
- Flexible kit sizes for proof-of-concept studies to massive projects, from 84,000 to 4 million cells