Refined Laser Systems develops a stain-free, molecular-specific microscopy technology that provides high-contrast tissue imaging from freshly excised specimens within minutes. This approach eliminates the need for traditional staining and sectioning processes, significantly reducing the time required for accurate tissue diagnostics.
Funding
$2.9M raised to dateRaised to date based on public sources. This may differ from the amount the company actually raised and is based only on what is publicly available on the internet.
HHFounders
Product
Problem
Traditional histology methods for tissue diagnostics are time-consuming, requiring staining and sectioning processes that can delay accurate results. These conventional techniques also may not fully capture the molecular composition and dynamic processes within living cells.
Solution
Refined Laser Systems provides advanced microscopy solutions that enable stain-free, molecular-specific tissue imaging within minutes. Their technology eliminates the need for traditional staining and sectioning, delivering high-contrast images from freshly excised, thick specimens. The Noctua stimulated Raman scattering (SRS) imaging system offers label-free imaging of living cells by exciting intrinsic molecular bonds, allowing researchers to observe cellular dynamics in real-time without photobleaching or labeling. This approach facilitates the identification of nuclei and cytoplasm without staining, revealing hidden structures and fine details with high spectral resolution.
Target Audience
The primary target audience includes pathologists, researchers in cell biology and material sciences, and professionals in semiconductor inspection requiring rapid, label-free tissue diagnostics and advanced laser technology for quantum applications.
Features
- **Noctua SRS Imaging System:**
- Provides label-free imaging of living cells and tissues using stimulated Raman scattering.
- Offers high-contrast, molecular-specific imaging without the need for staining or sectioning.
- Features a balanced detector for low-noise imaging and improved signal-to-noise ratio.
- Enables hyperspectral imaging across the Raman spectrum (700-3100 cm-1) with millisecond tuning speeds.
- Compatible with Evident Scientific (Olympus) BX63, FV3000 or Nikon Ti2 microscopes.
- **PICUS Q Tunable Picosecond Laser:**
- Offers mode-hop free tuning between 770 to 980 nm in milliseconds.
- Delivers up to 300 mW at the specified wavelength with high wavelength stability (< 6 pm).
- Provides high temporal coherence and pulse-to-pulse stability for quantum dot pumping.
- Features automated computer control and fiber-coupled outputs for flexible pulse delivery.