The startup develops RNA fragmentomics technology for real-time disease detection, enhancing diagnosis and treatment in cancer and infectious diseases. Their platform facilitates biomarker discovery, liquid biopsy, and single-cell analysis, enabling healthcare providers to improve patient outcomes through precise RNA-based diagnostics.
Funding
$5M raised to dateRaised to date based on public sources. This may differ from the amount the company actually raised and is based only on what is publicly available on the internet.
Founders
Product
Problem
Traditional RNA analysis techniques often overlook fragmented RNA, which constitutes a significant portion of the total RNA and contains valuable biological information. Current methods also suffer from biases during library preparation, leading to underdetection of certain RNA species. This incomplete analysis limits the ability to fully understand the transcriptome and discover novel biomarkers.
Solution
RealSeq Biosciences offers the RiboMarker® platform, a comprehensive solution for RNA fragmentomics that enables the discovery of novel biomarkers and provides deeper insights into the transcriptome. The platform utilizes a proprietary library construction method that minimizes incorporation bias, allowing for the detection and accurate quantification of RNA fragments that are missed by conventional techniques. By combining advanced Next-Generation Sequencing (NGS) with AI-powered bioinformatics tools, RiboMarker® unlocks next-generation RNA analytes for a wide range of diagnostic applications, including liquid biopsies for oncology and infectious diseases, as well as agricultural biotechnology. The platform's ability to analyze RNA fragments provides a more complete and dynamic picture of disease progression and therapeutic response.
Target Audience
The primary target audience includes researchers and clinicians in oncology, infectious disease, and agricultural biotechnology who seek to improve diagnostics and gain deeper insights into the transcriptome using RNA fragmentomics.
Features
- RiboMarker® RNA Fragmentomics Library Preparation Kit with single-adapter circularization technology to minimize bias during library preparation
- RealSeq®-Biofluids Small RNA Library Preparation Kit designed for low concentration RNA samples from biofluids
- RealSeq®-AC Small RNA Library Preparation Kit
- RealSeq® Dual Small RNA Library Preparation Kit
- Selective Suppression Probes (SSP™) for targeted removal of highly expressed RNA species to increase sequencing depth of less abundant fragments
- Ribo-ID® RT-qPCR Assay
- RealSeq® Index Primers
- Small RNA/RNA Fragmentomics Library Prep & Sequencing Service
- Total RNA Library Prep & Sequencing Service
- Small RNA/RNA Fragmentomics Library Prep Service
- Total RNA Library Prep Service
- Bioinformatics service including QC, trimming, and alignments to reference genomes
- Proprietary AI models for analyzing RNA fragmentomics data, including degradation, splicing, mutations, and base modifications