Raleigh Biosciences utilizes single-cell genomics and spatial transcriptomics to optimize gene expression and genome editing for crop trait production. By employing AI-driven models to identify genomic features that control gene expression, the company enables precise control over traits while minimizing negative pleiotropy associated with broad trait expression.
Funding
$200K raised to dateRaised to date based on public sources. This may differ from the amount the company actually raised and is based only on what is publicly available on the internet.
Founders
Product
Problem
Traditional methods of crop trait optimization through gene editing often result in unintended pleiotropic effects due to broad trait expression. Identifying and controlling the specific genomic features responsible for gene expression in specific cell types and developmental stages remains a challenge. This lack of precision hinders the development of crops with optimized traits and minimal negative side effects.
Solution
Raleigh Biosciences offers an end-to-end platform leveraging single-cell genomics, spatial transcriptomics, and AI-driven models to enable targeted control of gene expression for crop trait production. The company's technology identifies genomic features that drive gene expression in specific cell types, allowing for precise genome editing at promoters. This approach minimizes negative pleiotropy associated with broad trait expression. Raleigh Biosciences also utilizes patented 3D bioprinting technology to edit crop cells in a scalable manner, facilitating high-throughput testing and validation of gene expression drivers.
Target Audience
Raleigh Biosciences serves plant science researchers and agricultural companies seeking to optimize crop traits, enhance plant performance, and develop smarter ways to drive trait expression.
Features
- Single-cell transcriptomics to measure gene expression in individual cells or nuclei
- Spatial transcriptomics to measure and predict gene expression in spatial context of the tissue
- AI-driven models to predict cell type-specific expression patterns and unlock insights into gene expression and genome features
- Genome editing at promoters to control gene expression in specific cell types
- Patented 3D bioprinting technology to edit cells from crops in a scalable manner
- 10X Genomics platform combined with multiplex fluorescent _In situ_ hybridization (FISH)