Puxano is a platform-based CRO integrating AI-driven protein design with structure-based protein research, including cryoEM. The company utilizes proprietary Design-to-Structure and Gene-to-Structure workflows to accelerate the development of novel vaccines, protein therapeutics, and biopesticides. Services span computational analysis, biochemical assays, and high-resolution structure determination.
Funding
$260K raised to dateRaised to date based on public sources. This may differ from the amount the company actually raised and is based only on what is publicly available on the internet.
Founders
Product
Problem
Traditional protein design and engineering processes face significant challenges in protein expression, purification, and structure determination, creating bottlenecks in the development of protein therapeutics, vaccines, and biopesticides. Existing methods often lack the efficiency and precision required to tackle complex protein targets effectively.
Solution
PUXANO offers a platform-based CRO service that integrates AI-driven protein design and engineering with experimental structure-based protein research, including cryo-electron microscopy (cryoEM), to streamline the development of novel vaccines, protein therapeutics, and biopesticides. Utilizing proprietary Design-to-Structure or Gene-to-Structure workflows, PUXANO accelerates the process from protein sequence analysis and design to expression, purification, biophysical characterization, and high-resolution protein structure determination. The platform resolves bottlenecks encountered with standard technologies, making even the most challenging protein targets accessible. PUXANO provides services at any step of the Design-to-Structure or Gene-to-Structure workflow, including computational, biochemical, and cryo-electron microscopy services.
Target Audience
PUXANO's primary customers are biotechnology and pharmaceutical companies, as well as research institutions, involved in early-stage drug development, vaccine design, and the creation of sustainable crop protection solutions.
Features
- AI-assisted algorithms and structure-guided protein design techniques
- High-throughput protein expression and purification in bacterial expression systems
- Biophysical characterization, including protein stability and activity assays
- CryoEM grid screening and optimization using a Talos Arctica equipped with a Falcon IVi DED
- High-resolution protein structure determination using a Titan Krios equipped with a Gatan energy filter and Falcon III/K3 camera
- AI-assisted image processing for nanoparticle characterization
- Multi-Angle Light Scattering (MALS) as an orthogonal technique for nanoparticle analysis
- Proprietary PXN Grids for cryoEM sample preparation
- Computational services including protein analysis and design
- Biochemical services including protein expression, purification, stability, and binding assays