Promakhos Therapeutics focuses on developing novel therapies for inflammatory bowel disease and primary sclerosing cholangitis. The company investigates the role of the intestinal microbiome and genetic susceptibility in disease progression and treatment response. Their research aims to uncover better biomarkers and advance new therapeutic agents for chronic gastrointestinal inflammation.
Funding
$2.5M raised to dateRaised to date based on public sources. This may differ from the amount the company actually raised and is based only on what is publicly available on the internet.
Founders
Product
Problem
Current therapies for chronic inflammatory diseases, such as Crohn’s disease, multiple sclerosis, and ankylosing spondylitis, often suppress the entire immune system and treat symptoms rather than addressing the underlying causes of the disease, with only a fraction of patients benefiting long term. This approach can leave patients vulnerable to infection and may not provide sustained relief from inflammation.
Solution
Promakhos Therapeutics is developing oral immunomodulatory therapies designed to restore intestinal innate immune function and manage chronic inflammation in conditions like Crohn's disease. Their approach aims to re-establish the body's natural ability to control inflammation and promote healing, rather than broadly suppressing the immune system. By targeting the root causes of immune dysregulation, Promakhos seeks to improve patient outcomes and enhance long-term treatment efficacy. The company utilizes insights from patient samples to develop medicines that address the specific mechanisms driving inflammatory diseases.
Target Audience
The primary target audience includes patients suffering from chronic inflammatory diseases, such as Crohn's disease, and the physicians who treat them.
Features
- Oral drug candidate designed to restore intestinal innate immune function
- Focus on promoting wound healing to resolve bowel inflammation
- Approach does not broadly suppress the immune system
- Aims to re-establish the body's natural ability to manage inflammation and heal
- Target the root causes of immune dysregulation
- Utilizes insights from patient samples to develop medicines