Traditional biomanufacturing relies on imprecise and inefficient methods, such as temperature and chemicals, to indirectly control cell behavior, limiting the production of complex biomolecules and tissues. These indirect methods lead to challenges in achieving desired protein folding, preventing aggregation, and avoiding cytotoxicity, especially when producing therapeutic proteins, nutritional proteins, and cultured meat.

Prolific Machines offers a photomolecular platform that uses optogenetics, hardware, and AI to directly and precisely control cellular functions with light. This platform enables real-time manipulation of cell behavior, allowing for optimized production of proteins and complex tissues. By attaching light-sensitive proteins to target proteins within the cell, the platform can dynamically control cellular processes like gene expression, receptor activation, and enzyme activity. The platform's spatial control capabilities also enable the creation of complex tissue products by differentiating cells into specific cell types in a desired pattern.

Optogenetic tools for light-based control of cellular processes

Hardware for precise delivery of light signals with tunable intensity, color, and patterns

AI-powered software for optimizing cellular behavior and bioproduct output

Spatial control of cell differentiation for creating structured tissue products

Capability to control protein production, folding, and post-translational modifications

Ability to produce high titers of difficult-to-express proteins

Elimination of growth factors in cultured meat production

Use of non-ionizing light at low intensities for safe biomanufacturing

The primary customers are innovators and leaders across biopharmaceuticals and advanced nutrition, including companies involved in therapeutic protein production, nutritional protein production, cultured meat, and gene therapy production.