Prolific Machines offers a next-generation Cell Line Development platform that integrates optogenetic technology with AI-driven optimization for biomanufacturing. This Photomolecular™ platform uses light to dynamically control cellular processes, significantly boosting titers and improving consistency for difficult-to-express biotherapeutics. The system provides flexible, scalable solutions designed to lower COGS and enhance product quality across antibody and biosimilar production.
Funding
$96.6M raised to dateRaised to date based on public sources. This may differ from the amount the company actually raised and is based only on what is publicly available on the internet.
KTFounders
Product
Problem
Traditional biomanufacturing relies on imprecise and inefficient methods, such as temperature and chemicals, to indirectly control cell behavior, limiting the production of complex biomolecules and tissues. These indirect methods lead to challenges in achieving desired protein folding, preventing aggregation, and avoiding cytotoxicity, especially when producing therapeutic proteins, nutritional proteins, and cultured meat.
Solution
Prolific Machines offers a photomolecular platform that uses optogenetics, hardware, and AI to directly and precisely control cellular functions with light. This platform enables real-time manipulation of cell behavior, allowing for optimized production of proteins and complex tissues. By attaching light-sensitive proteins to target proteins within the cell, the platform can dynamically control cellular processes like gene expression, receptor activation, and enzyme activity. The platform's spatial control capabilities also enable the creation of complex tissue products by differentiating cells into specific cell types in a desired pattern.
Target Audience
The primary customers are innovators and leaders across biopharmaceuticals and advanced nutrition, including companies involved in therapeutic protein production, nutritional protein production, cultured meat, and gene therapy production.
Features
- Optogenetic tools for light-based control of cellular processes
- Hardware for precise delivery of light signals with tunable intensity, color, and patterns
- AI-powered software for optimizing cellular behavior and bioproduct output
- Spatial control of cell differentiation for creating structured tissue products
- Capability to control protein production, folding, and post-translational modifications
- Ability to produce high titers of difficult-to-express proteins
- Elimination of growth factors in cultured meat production
- Use of non-ionizing light at low intensities for safe biomanufacturing