This startup authenticates biological reagents used in in vitro ADMET (Absorption, Distribution, Metabolism, Excretion, and Toxicity) assays. By ensuring reagent reliability, they improve the accuracy and translatability of preclinical drug development data.
Funding
Funding not disclosed
Founders
Product
Problem
In preclinical drug development, inaccurate or unreliable biological reagents used in in vitro ADMET assays can lead to poor data quality, hindering the prediction of in vivo drug behavior and potentially resulting in costly late-stage failures. Traditional methods for protein quantification, such as Western blotting, lack the precision and throughput required for modern drug discovery.
Solution
Precision Quantomics provides quantitative proteomics tools and services that enable more accurate and efficient drug development. They offer a range of mass spectrometry-based assay kits and custom services for precise protein quantification in complex biological samples. These tools help researchers characterize in vitro reagents, validate novel in vitro models, and gain early predictive insights into potential drug-induced organ damage. By aligning with regulatory guidelines like the FDA Modernization Act 2.0, Precision Quantomics helps pharmaceutical companies meet evolving requirements for safety and efficacy. Their services support the transition to New Approach Methodologies (NAMs) by delivering quantitative proteomics assays specifically designed to characterize and qualify NAM platforms.
Target Audience
The primary customers are pharmaceutical and biotech companies, academic laboratories, contract research organizations, and biological reagent companies involved in drug discovery and development.
Features
- MSQ-DILI/DIKI Assay Kit: Quantifies biomarkers for drug-induced liver and kidney injury using LC-MS proteomics.
- MSQ-CYP Assay Kit: Enables precise quantification of 11 key human cytochrome P450 (CYP450) enzymes involved in drug metabolism using LC-MS/MS.
- MSQ-DTR Assay Kit: Provides quantification of eight key human membrane transport proteins.
- MSQ-UGT Assay Kit: Quantifies nine key human UGT enzymes involved in drug metabolism.
- Employs validated stable isotope-labeled (SIL) surrogate peptides for accurate protein quantification.
- Services include protein quantification at femtomole to attomole levels from complex biological samples.
- Offers targeted and global proteomics services, specializing in transmembrane proteins.
- Provides custom method development for quantification of specific proteins.