Portal Biotechnologies develops proprietary membrane technology utilizing mechanical disruption for massive parallelization in cell engineering. This platform enables efficient delivery of diverse cargo into various cell types for applications in drug discovery and cell therapy. The company provides tools and technology to enhance antigen presentation and therapeutic payload delivery across multiple cell modalities.
Funding
$17.7M raised to dateRaised to date based on public sources. This may differ from the amount the company actually raised and is based only on what is publicly available on the internet.
Founders
Product
Problem
Many research and clinical applications require efficient intracellular delivery of biomolecules like RNA and gene editing tools, but existing methods often struggle with cell viability, delivery efficiency, and scalability across diverse cell types. This limits advancements in gene expression modulation, pathway activation, and the development of cell-based therapies.
Solution
Portal provides a cell engineering platform that leverages a proprietary mechanical delivery system to facilitate intracellular delivery of a variety of therapeutic cargo across diverse cell types. The technology enables efficient gene expression modulation, pathway activation, and the development of cell-based therapies. Portal's system is designed to be compatible with R&D scale experiments, high-throughput integrations, clinical scale integrations, and even point-of-care system integrations. This allows for same-day production of autologous, therapeutic cells at the patient bedside.
Target Audience
The primary target audience includes biotech companies, big pharma, academics, and cell therapy manufacturers involved in cell engineering, drug discovery, and the development of cell-based therapies.
Features
- Proprietary mechanical delivery system for efficient intracellular delivery
- Compatible with RNA, gene editing tools, and other therapeutic cargo
- Supports gene editing (deletion, correction, integration), gene expression modulation (up/down-regulation, exogenous expression), and pathway modulation
- Enables probing of the intracellular environment, including intracellular measurements, remote control, labeling, and novel inhibitors
- Designed for R&D scale, high throughput integrations, clinical scale integrations, and point-of-care system integrations
- Consumables compatible with common manufacturing equipment