Portal Biotech provides a bench‑top nanopore platform that detects individual proteins, peptides, and small molecules as they pass through a nanoscale pore, generating electrical signatures that are decoded by machine‑learning algorithms into full‑length sequences and modification details. The system offers real‑time, quantitative results across three assay modes—including intact‑protein sequencing and peptide‑fragment analysis—enabling researchers in academia and biopharma to characterize proteoforms and metabolites with high sensitivity and low cost.
Funding
$37.1M raised to dateRaised to date based on public sources. This may differ from the amount the company actually raised and is based only on what is publicly available on the internet.
8ONIFounders
Product
Problem
Current proteomic analysis methods often require large, expensive instruments, extensive sample preparation, and bulk measurements that obscure single-molecule heterogeneity. This limits researchers’ ability to accurately identify and quantify protein isoforms, post‑translational modifications, and small‑molecule metabolites in a rapid, cost‑effective manner.
Solution
Portal Biotech offers a bench‑top nanopore platform that detects individual protein, peptide, and small‑molecule molecules as they pass through a nanoscale pore. Each translocation generates a unique electrical signature, which is decoded by machine‑learning algorithms to reveal the molecule’s identity, full‑length sequence, and any modifications. The system supports both intact‑protein sequencing and peptide‑fragment analysis, enabling complete coverage of proteoforms. Results are delivered in real time, with quantitative molecule counts and flexible assay formats that can be integrated into existing laboratory workflows.
Target Audience
Primary customers are academic researchers, biopharma R&D teams, and biotechnology service labs that require detailed, single‑molecule protein and metabolite characterization for drug discovery, biomarker validation, and basic biology studies.
Features
- Nanopore biosensor that captures single molecules and produces high‑resolution electrical signatures
- Integrated machine‑learning pipeline that translates signatures into detailed sequence and modification information
- Three assay modes: small‑molecule detection, peptide spectrometry (NPS) compatible with mass‑spec workflows, and full‑length protein sequencing
- Ability to analyze proteins >100 kDa and discriminate chirality, isobaric variants, and post‑translational modifications
- Rapid, real‑time data output with quantitative molecule counting
- Bench‑top instrument design for cost‑effective deployment in academic, biotech, and pharmaceutical labs
- Scalable workflow supporting low‑throughput research to high‑volume service‑core operations