Pixel Biosciences specializes in the synthesis of customized RNA and DNA reagents, including sgRNA and CRISPR gene editing tools, utilizing their proprietary nMECA technology to significantly reduce impurities in mRNA synthesis. Their solutions enhance the precision and efficiency of gene editing and drug development processes in research and clinical applications.
Funding
Funding not disclosed
Founders
Product
Problem
Gene editing and drug development rely on high-quality RNA and DNA reagents, but traditional synthesis methods often produce mRNA with significant levels of impurities, such as double-stranded RNA (dsRNA), which can compromise experimental results and therapeutic efficacy. Researchers need access to customized, high-purity oligonucleotides to enhance the precision and reliability of their work.
Solution
Pixel Biosciences provides customized RNA and DNA reagents, including sgRNA, pegRNA, and CRISPR gene editing tools, synthesized using its proprietary nMECA technology. The nMECA platform significantly reduces impurities, particularly dsRNA in mRNA synthesis, by up to 100-fold compared to conventional methods. This results in reagents with greater than 90% purity, improving the efficiency and accuracy of gene editing, spatial biology, proteomics, and drug development applications. Pixel Biosciences also offers NovaFISH probes for single-molecule FISH (smFISH) applications, featuring combinatorial color barcoding and AI-powered data analysis.
Target Audience
Pixel Biosciences serves researchers and companies in gene editing, drug development, spatial biology, proteomics, and related fields who require high-quality, customized RNA and DNA reagents.
Features
- Customized synthesis of RNA and DNA oligonucleotides up to 300 nucleotides in length
- Proprietary nMECA technology for reduced dsRNA impurities in mRNA synthesis
- High purity (greater than 90%) for enhanced experimental reliability
- NovaFISH probes for multiplexed single-molecule FISH with combinatorial color barcoding
- Fluorescent ssDNA ladders for nucleic acid sizing and quantification
- Capability to perform chemical modifications on synthesized RNA
- CDMO and CRO services for customized synthesis and assay development