Phinomics provides a patented platform that isolates and decodes extrachromosomal circular DNA and cryptic micro-proteins, which are key drivers in cancer and immune dysfunction. This technology reveals previously invisible biology that conventional sequencing methods miss, offering a more complete view of disease mechanisms. By integrating these causal elements, the company aims to enable more accurate target discovery for next-generation therapeutics.
Funding
Funding not disclosed
Founders
Product
Problem
Existing sequencing technologies often fail to capture a complete picture of the dynamic regions within the genome. This incomplete understanding hinders advancements in personalized medicine, particularly in identifying novel biomarkers and therapeutic targets for complex diseases. The limitations of current methods impede the ability to fully characterize the role of circular DNA in disease etiology, progression, and drug resistance.
Solution
Phinomics is developing the Circulome Atlas, a patented dataset that maps circular DNA across various tissues, cell types, and pathological conditions. By integrating biology and AI, Phinomics aims to identify novel biomarkers and therapeutic targets, particularly in precision oncology. Their approach unveils intricate biological networks underlying cancer and other diseases, opening new therapeutic pathways and deepening the understanding of cellular mechanisms. The Circulome Atlas provides a comprehensive view of circular DNA, which operates outside the constraints of chromosomes and contributes to drug resistance.
Target Audience
The primary audience includes researchers and clinicians in precision oncology, target discovery, and drug development who seek to leverage circular DNA insights for improved disease understanding and treatment strategies.
Features
- Multi-dimensional datasets integrating engineering, data science, genomics, immunology, and cancer biology
- Identification of circular DNA biomarkers and therapeutic targets
- Analysis of circular DNA's role in disease etiology, progression, and drug resistance
- AI-driven mining of the Circulome Atlas to enable prediction and treatment of disorders driven by changes in DNA sequence and structure