Paragon Genomics provides CleanPlex® amplicon-based next-generation sequencing (NGS) panels that enable precise target enrichment for genomic testing in areas such as infectious disease and precision oncology. Their technology addresses the need for high sensitivity and specificity in detecting low-frequency variants, facilitating rapid and accurate genomic analysis.
Funding
$8M raised to dateRaised to date based on public sources. This may differ from the amount the company actually raised and is based only on what is publicly available on the internet.
CVFIFounders
Product
Problem
Next-generation sequencing (NGS) for genomic testing requires precise target enrichment, but traditional methods often lack the sensitivity and specificity needed to detect low-frequency variants accurately. This limitation hinders rapid and reliable genomic analysis, particularly in applications like infectious disease monitoring and precision oncology where early detection is critical.
Solution
Paragon Genomics provides CleanPlex® amplicon-based NGS panels that enable highly sensitive and specific target enrichment for genomic testing. CleanPlex technology uses a multiplex PCR-based approach with a streamlined workflow to amplify target regions of interest. The technology incorporates a unique background cleaning step to reduce PCR-induced errors, enhancing the detection of low-frequency variants. CleanPlex panels are available as ready-to-use kits or can be custom-designed to meet specific research or diagnostic needs.
Target Audience
The primary customers are researchers and clinical labs in fields such as infectious disease, precision oncology, inherited disease, and molecular breeding who require targeted NGS solutions.
Features
- Multiplex PCR-based target enrichment for DNA or RNA sequencing
- Streamlined 3-hour workflow for rapid library preparation
- Low DNA/RNA input requirements
- Ability to design panels with up to 20,000 amplicons per pool
- Unique PCR background cleaning for improved accuracy
- UMI-based error correction for ultra-sensitive variant detection (down to 0.1% allele frequency)
- Optimized reverse transcription for RNA gene fusion detection
- Custom panel design services available