This company develops foundational technology that merges molecular specificity with nanoscale ultrastructure for biological imaging. They offer full-service tissue preparation, imaging, and AI-powered segmentation using proprietary pan-ExM technology. Their platform enables researchers to localize molecular markers within tissue architecture using accessible, high-throughput light microscopy.
Funding
Funding not disclosed
Founders
Product
Problem
Traditional microscopy techniques are limited in their ability to resolve subcellular structures and protein clusters within intact tissues at high magnification without compromising ultrastructural integrity. This limitation hinders comprehensive analysis of complex biological processes at multiple scales.
Solution
Panluminate offers a novel expansion microscopy platform that enables up to 25x volumetric expansion of cell and tissue samples, preserving ultrastructural detail. The core technology utilizes a proprietary fluorescent pan-staining protocol that generates ultrastructural contrast, achieving resolution comparable to electron microscopy. This multi-level expansion capability allows for detailed investigation from the single-cell level down to subcellular compartments and protein cluster organization. The platform is designed for compatibility with a broad spectrum of labeling modalities, including standard antibodies and nucleic acid fluorescent in situ hybridization (FISH).
Target Audience
The primary target audience includes academic researchers and industry scientists in fields such as oncology, neuroscience, and pathology, who require advanced imaging capabilities for subcellular and molecular analysis.
Features
- Volumetric sample expansion up to 25x in three dimensions, maintaining ultrastructural integrity.
- Proprietary fluorescent pan-staining for enhanced ultrastructural contrast at EM-level resolution.
- Multi-resolution imaging capabilities, enabling analysis from single-cell to subcellular and protein cluster levels.
- Broad compatibility with various labeling techniques, including antibodies, DNA FISH, RNA FISH, and lipid stains.
- Enables investigation of preclinical drug development, amyloid plaque characterization, mitochondrial abnormalities, and neural circuit mapping.