PainVox develops an innovative PET radiotracer, PV-1 / FTC-146, designed to locate occult pain generators in chronic pain conditions. This technology provides actionable insights for planning and guiding targeted treatments, moving beyond palliative care to address specific underlying pain sources. The use of this imaging agent facilitates precision targeting, leading to improved efficacy and better clinical and financial outcomes for patients suffering from complex pain syndromes.
Funding
Funding not disclosed
Founders
Product
Problem
Current methods for diagnosing chronic pain, such as MRIs, X-rays, and clinical exams, often lack the sensitivity and accuracy needed to pinpoint the specific origins of pain. This can lead to ineffective or misguided treatments, including unnecessary surgeries and reliance on palliative medications.
Solution
PainVox is developing a PET radiotracer technology, PV-1, designed to precisely locate the tissue voxels responsible for generating chronic pain. By binding to Sigma-1 receptors, the radioligand enables accurate detection of the molecular underpinnings of pain, specifically pinpointing pro-nociceptive pathology through PET/MR imaging. This diagnostic approach aims to improve care planning and guide targeted treatment, potentially transitioning the field from palliative care to curative solutions that address specific, underlying pain generators. Early clinical trials have demonstrated the ability of PV-1 to locate occult pain generators across a variety of conditions, providing actionable insights to aid planning and guide targeted treatment.
Target Audience
The primary target audience includes healthcare providers, such as physicians and surgeons, who treat patients with difficult-to-diagnose and treat chronic pain, as well as clinical researchers in the pain management field.
Features
- PV-1 radiotracer targets Sigma-1 receptors to identify sites of pain generation.
- PET/MR imaging provides objective visualization of painful tissue.
- Facilitates selection of new treatments and improves efficacy of existing therapies.
- Enables more precise and effective care, potentially reducing costs.
- Can identify the origin of pain even in unexpected locations.