ONI develops super-resolution microscopy tools, including the Nanoimager and Aplo Flow, to facilitate single-molecule imaging for researchers in various fields. Their technology simplifies sample preparation and data analysis, enabling more accurate and reproducible results in studies involving lipid nanoparticles and other biological samples.
Funding
$113.3M raised to dateRaised to date based on public sources. This may differ from the amount the company actually raised and is based only on what is publicly available on the internet.
Founders
Product
Problem
Conventional optical microscopy is limited by the diffraction of light, preventing researchers from visualizing cellular and molecular structures at a nanoscale resolution. This limitation hinders the detailed study of biological processes and the understanding of molecular interactions within cells and other biological samples.
Solution
ONI develops super-resolution microscopy solutions that overcome the diffraction limit of light, enabling researchers to visualize structures at a 10x greater resolution than previously achievable. The company's portfolio includes the Nanoimager, a compact benchtop microscope capable of multiple super-resolution imaging modalities such as dSTORM, PALM, and DNA-PAINT. ONI also offers Aplo Flow, an automated fluidic control system for application-specific sample preparation, and CODI, a cloud-based analysis platform for collaborative data processing and workflow sharing. These integrated tools simplify sample preparation, data acquisition, and analysis, providing researchers with a comprehensive solution for single-molecule imaging and nanoscale investigations.
Target Audience
ONI's primary customers include researchers in academic institutions, research facilities, biotechnology companies, and pharmaceutical firms engaged in cell biology, drug discovery, and medical research related to infectious diseases, extracellular vesicles, neuroscience, and immuno-oncology.
Features
- Nanoimager: A compact, benchtop microscope supporting multiple super-resolution modalities (dSTORM, PALM, PAINT, Single-Particle Tracking, smFRET, TIRF, HILO)
- Aplo Flow: An application-specific, customizable sample preparation system with automated fluidic control for reliable and reproducible SMLM workflows
- CODI: A cloud-based platform for data analysis, collaboration, and workflow sharing, featuring tools for clustering, filtering, and single-molecule analysis
- dSTORM: Super-resolution microscopy technique allowing for resolutions under 20 nm, enabling detailed visualization of structures and molecule localization
- DNA-PAINT: Super-resolution technique compatible with multicolor imaging and live samples, benefiting from continuous fluorophore replenishment
- Single Particle Tracking (SPT): Enables tracking of single molecules and vesicles in both bacterial and eukaryotic cells
- Consumable kits: Streamline sample preparation, offering optimized reagents and protocols for various applications, including cells and nanoparticles