Nature’s Toolbox offers a benchtop, cell-free biomanufacturing platform that produces high-quality RNA, including mRNA and saRNA, in a scalable and efficient manner. This technology addresses the challenges of high costs and lengthy production times in the development of vaccines and therapeutics, enabling faster access to critical biologic materials.
Funding
$60.5M raised to dateRaised to date based on public sources. This may differ from the amount the company actually raised and is based only on what is publicly available on the internet.
JMFounders
Product
Problem
Traditional cell-based biomanufacturing of RNA, including mRNA and saRNA, suffers from high costs, lengthy production times, and scalability challenges, hindering the rapid development and access to vaccines and therapeutics. Current methods struggle to efficiently produce complex RNA constructs, particularly self-amplifying RNA (saRNA), which are difficult to manufacture using commercially available equipment and processes.
Solution
Nature's Toolbox (NTx) offers NTxscribe, a benchtop, cell-free biomanufacturing platform designed to produce high-quality RNA, including mRNA and saRNA, in a scalable and efficient manner. The NTxscribe system and proprietary enzymes enable more efficient production of complex RNA compared to traditional systems, delivering consistently high-quality RNA on-demand and at a lower cost than outsourced manufacturing. The system operates with push-button ease and linear scalability, facilitating easy construct changes and increased production.
Target Audience
The primary target audience includes researchers and companies in the biopharmaceutical industry involved in the development of vaccines and therapeutics, particularly those working with RNA-based modalities.
Features
- Benchtop, plug-and-play continuous flow system for mRNA IVT and purification
- Proprietary enzymes optimized for cell-free RNA production
- Scalable production from R&D to clinical trial quantities
- Rapid production, delivering 10-50 mg of high integrity mRNA in approximately 3 hours
- Efficient manufacturing of complex RNA constructs, including self-amplifying RNA (saRNA)