Neuromagen develops small‑molecule telomerase activators (AGS compounds) that protect neurons, improve mitochondrial function, and reduce oxidative stress. Their preclinical data show benefits across neurodegenerative models such as ALS and Alzheimer’s, as well as anti‑aging effects on hair, skin, fertility, and metabolic health, positioning the platform for multiple age‑related disease indications.
Funding
Funding not disclosed
Founders
Product
Problem
Neurodegenerative, metabolic, cardiovascular and age‑related diseases often involve oxidative stress, mitochondrial dysfunction, and cellular senescence, leading to neuronal loss, vascular aging, and impaired tissue regeneration. Current therapies address symptoms but do not reverse underlying cellular damage.
Solution
Neuromagen’s platform uses small‑molecule telomerase activators (AGS compounds) to up‑regulate telomerase reverse transcriptase (TERT) in target cells. By enhancing telomerase activity, the compounds reduce oxidative stress, protect mitochondrial function, and promote cellular vitality. Preclinical studies show neuroprotection in amyloid‑beta‑exposed hippocampal neurons, lowered amyloid plaque burden and improved cognition in Alzheimer’s mouse models, and protection of motor neurons in ALS models. The same mechanism restores endothelial function in human coronary microvessels, improves glucose tolerance and β‑cell survival in diabetic mice, and stimulates hair follicle and reproductive tissue regeneration, indicating broad rejuvenation potential across multiple organ systems.
Target Audience
Primary customers are pharmaceutical companies and biotech developers seeking disease‑modifying agents for neurodegenerative, metabolic, cardiovascular and age‑related indications, as well as research institutions investigating telomerase‑based rejuvenation therapies.
Features
- Small‑molecule AGS compounds that selectively activate telomerase (TERT) in neurons, vascular cells, and stem cells
- Demonstrated reduction of oxidative stress and enhancement of mitochondrial health in vitro and in vivo
- Neuroprotective efficacy in ALS (hSOD1 Tg) and Alzheimer’s (5XFAD) mouse models, including decreased amyloid plaques and improved cognitive behavior
- Restoration of endothelial vasodilation and reversal of vascular aging in human coronary microvessels from CAD patients
- Metabolic benefits in diabetic mice: β‑cell protection, lowered fasting glucose, improved glucose tolerance, and normalized kidney function
- Regenerative effects on hair follicles, skin, and reproductive tissues, showing increased hair growth, follicle activation, and fertility restoration
- Broad indication coverage: neurodegeneration, fertility, diabetes, cardiovascular disease, hair/skin aging, and age‑related macular degeneration