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MyT Bioscience discovers potent and selective inhibitors targeting the protein kinase PKMYT1. These inhibitors are synthetically lethal in cancers driven by cyclin E, addressing significant unmet medical needs. The compounds are orally bioavailable and demonstrate potential to enhance the efficacy of DNA-damaging antibody-drug conjugates.
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- MyT Bioscience discovers potent and selective inhibitors targeting the protein kinase PKMYT1. These inhibitors are synthetically lethal in cancers driven by cyclin E, addressing significant unmet medical needs. The compounds are orally bioavailable and demonstrate potential to enhance the efficacy of DNA-damaging antibody-drug conjugates.