MaxWell Biosystems develops high-density microelectrode array platforms, MaxOne and MaxTwo, for high-throughput functional imaging of iPSC-derived cells, enabling detailed monitoring of neuronal activity and drug responses. Their technology addresses the need for precise safety pharmacology and toxicology assessments in preclinical drug discovery, facilitating faster and more reliable research outcomes.
Funding
$4.7M raised to dateRaised to date based on public sources. This may differ from the amount the company actually raised and is based only on what is publicly available on the internet.
Founders
Product
Problem
In preclinical drug discovery, traditional methods for assessing safety pharmacology and toxicology often lack the throughput and resolution needed to accurately monitor cellular activity and drug responses, particularly in iPSC-derived cells. This can lead to delays and increased costs in identifying potential safety issues early in the development process.
Solution
MaxWell Biosystems offers high-density microelectrode array (HD-MEA) platforms, including MaxOne and MaxTwo, designed for high-throughput functional imaging of cells. These platforms enable detailed, label-free monitoring of cellular and network activity, as well as responses to electrical stimulation and pharmacological compounds. The CMOS-based HD-MEA systems integrate amplifiers, filters, and digitizers directly within the MEA well, close to the cells under study, allowing for precise, long-term monitoring of single-cell activity and network dynamics. MaxWell Biosystems' solutions facilitate more reliable safety pharmacology and toxicology assessments, accelerating preclinical drug discovery.
Target Audience
The primary target audience includes researchers and drug developers in the fields of safety pharmacology, toxicology, and neuroscience, particularly those working with iPSC-derived cells, neuronal networks, and brain organoids.
Features
- CMOS-based high-density microelectrode array (HD-MEA) technology for high-resolution, label-free detection of cellular activity
- MaxOne: Single-well MEA system for detailed analysis of individual cell networks
- MaxTwo: Multiwell MEA system for high-throughput screening and comparative studies
- MaxLab Live Software: Comprehensive software suite for data visualization, recording, and analysis, including an AxonTracking Assay
- Optimized surface for cell culturing, enhancing signal quality and electrical stimulation
- Accessories and well plates designed specifically for MaxOne and MaxTwo systems
- Capability for selective electrical stimulation and long-term monitoring of cellular networks
- Applications include iPSC-derived neurons, neuronal networks, retina, brain slices, cardiomyocytes, and brain organoids