Develops a precision optogenetic platform that uses light-sensitive inhibitory G protein-coupled receptor opsins to selectively modulate pathological neural activity in real time. This approach targets specific neurons and pathways to treat severe neurological disorders, such as epilepsy and Parkinson’s disease, while minimizing side effects associated with conventional therapies.
Funding
$6.7M raised to dateRaised to date based on public sources. This may differ from the amount the company actually raised and is based only on what is publicly available on the internet.
Founders
Product
Problem
Current treatments for severe neurological disorders often lack precision, leading to broad effects on brain function and unwanted side effects. Existing therapies struggle to selectively target the specific neurons and pathways responsible for pathological activity. This results in millions of patients being overtreated, hindering their well-being and quality of life.
Solution
Modulight Bio is developing a precision optogenetic platform for treating severe neurological disorders by selectively modulating pathological neural activity in real time. The platform uses light-sensitive inhibitory G protein-coupled receptor (GPCR) opsins to precisely target affected neurons and pathways, restoring balance to the brain. By combining next-generation opsins with validated gene and light delivery methods, Modulight Bio aims to create a new class of brain network therapeutics. This approach allows for precise control over which cells and pathways are modulated and when light is delivered, minimizing unwanted side effects.
Target Audience
The primary target audience includes patients suffering from severe neurological disorders characterized by pathological brain activity, as well as neurologists and medical researchers seeking more precise and effective treatment options.
Features
- Next-generation inhibitory GPCR opsins that reduce communication between neurons on demand when activated with light.
- Optogenetic technology enabling precise spatial and temporal control of neural activity.
- Gene delivery methods for introducing opsins to targeted neurons.
- Light delivery techniques for activating opsins in specific brain regions.
- Potential applications for treating epilepsy, Parkinson’s disease, neuropathic pain, essential tremor, and narcolepsy.