Mission Bio offers the Tapestri Platform, an end‑to‑end single‑cell multi‑omics solution that simultaneously captures targeted DNA variants, surface‑protein markers, and optional RNA reads from thousands of individual cells. This enables researchers to resolve clonal heterogeneity, edit zygosity, and genotype‑phenotype relationships in cancer and gene‑editing studies with subclone detection down to 0.1%.
Funding
Funding not disclosed
3OABFounders
Product
Problem
Researchers studying heterogeneous diseases such as cancer and gene‑edited cell therapies lack tools that can simultaneously capture genetic mutations, copy‑number changes, and protein or transcript phenotypes at single‑cell resolution. Bulk sequencing masks rare subclones, edit zygosity, and off‑target effects, limiting insight into disease mechanisms, therapy response, and safety assessment.
Solution
Mission Bio’s Tapestri Platform provides an end‑to‑end single‑cell multi‑omics workflow that combines targeted DNA sequencing (SNV, indel, CNV, LOH, translocations) with surface‑protein profiling and, when needed, targeted RNA readouts—all from the same cell. A proprietary two‑step microfluidic process isolates DNA and oligo‑conjugated antibodies, then performs multiplex PCR to generate sequencing‑ready libraries. Integrated Tapestri Pipeline software automates data processing, visualization, and report generation, delivering intuitive plots of genotype‑phenotype relationships, clonal architecture, and editing outcomes. The system is compatible with existing NGS instruments and supports custom or pre‑designed panels for oncology, hematology, genome‑editing, and other applications, enabling researchers to detect rare subclones down to 0.1%, assess edit zygosity, and correlate molecular signatures with protein expression in a single assay.
Target Audience
Primary customers are academic, biotech, and pharmaceutical research labs focused on cancer genomics, hematologic malignancies, and cell‑ and gene‑therapy development that require high‑resolution single‑cell multi‑omics data.
Features
- Two‑step microfluidic workflow that simultaneously captures DNA variants and oligo‑conjugated antibody tags from thousands of individual cells
- Targeted single‑cell DNA panels detecting SNVs, indels, CNVs, LOH, and translocations with sensitivity to subclones as low as 0.1%
- Integrated protein panels (TotalSeq‑D) for concurrent surface‑marker profiling, enabling genotype‑phenotype correlation
- Optional targeted RNA modules for combined DNA, protein, and transcript analysis in the same cells
- Custom panel design via Tapestri Designer with AI‑optimized primer selection for human, mouse, or custom genomes
- Seamless integration into existing NGS pipelines and automated analysis through Tapestri Pipeline/Insights software (UMAP, violin, fish plots, etc.)
- Sample multiplexing and antibody hashing to increase throughput and reduce reagent costs
- Rental program offering instrument access without upfront capital expenditure